Protein Alignment Gyc76C and gcy-4

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_496218.2
• Gene: gcy-4 / 191642
• WormBaseID: WBGene00001531
• Length: 1136
• Species: Caenorhabditis elegans
• Alignment Length: 1175
• Identity: 345/1175 - (29%)
• Similarity: 552/1175 - (46%)
• Gaps: 205/1175 - (17%)

  Fly    23 RTVLTVGYLTALTGDLKTRQG----LAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLA 83
            |.|:.||    :|..|||..|    ....||:.:||..: |....:.|...:.....|:.|....
 Worm    25 RPVIRVG----ITAALKTENGSIGWAYTGGAVPLALQYL-KSHGYMLNFDFEFHVEYTECDLANT 84

  Fly    84 TKA-ITEMICDGIATIFGPEGPC----------------------YV-EAIVSQSRNIPMISYKC 124
            .:| :..|..:....|.||  ||                      :| |:.:|.....|.:
 Worm    85 VRAGLNFMKTNNYDVIIGP--PCAPALKMMGTLSTIYKKPVLGWGFVSESEISDMNRFPFV---- 143

  Fly   125 AEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINH 189
                ||.:|: .:|    ..||.|  .||..|.|::.::||          .|::....:..:|.
 Worm   144 ----ASVLPS-TKT----LGVVTS--KLLEIYGWDRVALLY----------FKNELDYCSSVVND 187

  Fly   190 KQSFIDNRVKCCEQM----LDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFA 250
            .:..:.|..|..:.:    :|...|......:|....|.|:.:|...|.....|.  :..|||..
 Worm   188 VEKSLYNESKSVQIVMKAEIDGSNSESTSATLQVVKTRARVILFCAHAGGEKRFY--LIQAGLLG 250

  Fly   251 --RGEYMVIFVDM------MVYSEREAEKYLRRVDQI--TFMSNCHSTENF-NQMARSLLVVAST 304
              ..||:.:.:.|      :..|..:....|..:..|  :|..|....|:. ..:|..::|:.::
 Worm   251 MNSSEYVHVMLSMRSVGFGVQTSVGKKPLTLSGLPPIWESFTVNPDGMEDLAKSVAAKMIVIDTS 315

  Fly   305 PPTKD--YIQF-TKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLR 366
            ...:|  ::|: ||.:.....:||.:.::|...:.:  :..:..||.:|:|...:|..||..:..
 Worm   316 SEVRDKTFLQYMTKNIVYAIREPPLSCKVPECLITN--ATGMGAYARHLFDVFYMYGMAVSSLNS 378

  Fly   367 EETRVLTD--------DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYK 423
            .:..|..:        ...||..:...::.:.:.:...| .:.|...:.||.  |..:.|::
 Worm   379 TDPNVYGNLSLLIPKFTTAFEGMTGEVKLNEDLARKPLY-QVYGLNSEYDQI--SLIDISLI--- 437

  Fly   424 PHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSID----WPSGGEKPADEPMCGFANELCK 484
                |::.|:..||                   .:|:.:    |  ||.:|.|.|:|||..:.|.
 Worm   438 ----NDTVNVVFNY-------------------ADGNTEVWHFW--GGTRPPDTPVCGFLGKSCP 477

  Fly   485 KD--DTHYTSTVAAVVLGVLLFCSGVITMS------------IYRKW-----KIELEIEGLLWKI 530
            ..  :.:....:.|:.:.:|:..:.:|.||            ::.:|     |:.|.:.....|
 Worm   478 LPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHRRASK- 541

  Fly   531 DPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWT-----NQFVTSTGRLRGAVVRIKELKFPRKRD 590
            ...|.:..|.:|..:..||........:...:|     |..|.:|..      :::||.
 Worm   542 SSQESETESASETENFTSKSGDTMTSEFKETYTIQYLENDLVLTTAH------QVQELS------ 594

  Fly   591 ISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLI 655
             ..|:||.:: ||:|.|:|:|.|||.|::.:|.:.|...|::|||.|||......:|..|:..:|
 Worm   595 -QAEMMKFVK-LRKLDHENLNKFIGLSIDGSRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFCMI 657

  Fly   656 HDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWR 720
            .|:.:|:.|||.|.|.:||||:|:.|:|...|.:::.||||    |..::|.  |....:|.||.
 Worm   658 RDIAEGLHYIHKSFLRHHGNLRSATCLVNDSWQVKLADFGL----QFLQDEE--EKPFKKNMLWA 716

  Fly   721 APELLRNHIHGSQ---KGDVYAFAIIMYEIFS---------RKGPFGQINFEPKEIVDYVKKLPL 773
            |||::|..:...|   ..|:|:|||:..||.:         ||..:.:|.:.       |||
 Worm   717 APEVIRGSLSIEQMDSSADIYSFAIVASEILTKREAWDLSRRKEGYEEIKYA-------VKK--- 771

  Fly   774 KGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMME 838
            .|:...||::...||....   :||.::|||.|:|||||....:...|..|......|:||.:..
 Worm   772 GGQFVLRPDLHIDIEVNQT---LLALVKDCWCENPEERPSAENVCKVLFDMTPNTEDNLMDHVFS 833

  Fly   839 MMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIV 903
            |:|:|.::||..|.|||:.|..||.|::.||.||||:.|||:|..||.|||.|:||||::|||:|
 Worm   834 MLEEYTSSLEVEVGERTKELTLEKKKSDILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLV 898

  Fly   904 GFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASM 968
            .||.::::.:|.||||.|||:::.||.||..:||||||:|||.::.|||||.:||..|..:|..|
 Worm   899 KFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHDVYKVESIGDGFLCVSGLPNRNGMEHIRQIVGM 963

  Fly   969 ALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALK 1033
            :|..:...:..||.|.|.|.::||:|:::||.|||||||:|||||||||||||||||||||:...
 Worm   964 SLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSM 1028

  Fly  1034 IHISNKC-KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPP--PLF 1095
            ||:|... .|.::.....:.|..||.|.:||||.:.|:||.|       |..:.....||  .:.
 Worm  1029 IHMSEAAHSLLVNNYPYQFETNSRGEVIIKGKGVMETYWLLG-------KMSLSNQSTPPITKVN 1086

  Fly  1096 SRPRK 1100
            .:|||
 Worm  1087 HKPRK 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	92/472 (19%)
		PK_GC-A_B	543..827	CDD:270944	94/300 (31%)
		HNOBA	<833..881	CDD:462234	24/47 (51%)
		CYCc	860..1052	CDD:214485	103/192 (54%)
gcy-4	NP_496218.2	PBP1_NPR_GC-like	29..444	CDD:380575	90/460 (20%)
		Protein Kinases, catalytic domain	558..819	CDD:473864	93/293 (32%)
		HNOBA	<832..876	CDD:462234	22/43 (51%)
		Guanylate_cyc	882..1070	CDD:425528	99/187 (53%)