Protein Alignment Gyc76C and gcy-1

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 1231
• Identity: 354/1231 - (28%)
• Similarity: 563/1231 - (45%)
• Gaps: 199/1231 - (16%)

  Fly     6 FNLLLLL----SVAVRDCSN----HRTVLTVGYLTALTGDLKTRQ-GLAI-SGALTMALDEVNKD 60
            |.:|||.    |:.|::..:    .||..|:....|....::|.. |.:: .||:.:|::.: |:
 Worm     4 FTILLLFNIFPSIFVQNLPDTTVAPRTKRTIKIGIAAAQRIQTSSIGWSVCGGAVPLAIERL-KE 67

  Fly    61 PNLLPNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIFGPEGPCYVEAIVSQSRNIPMISYKC 124
            ...:.:...:...:.|:.|.....:|..|.| ...:..|.||  ||        ::.:.::|:..
 Worm    68 MGFVKDFDFEYIVDYTECDLGSVVRAGMEFIKTHKVDVIIGP--PC--------AQALRLMSFLA 122

  Fly   125 AEYRASAI----------------PTFARTEPPDTQVVKSLLALLRYYAWNKFSILY-------- 165
            ..|:...:                |......|....:..:...:|..:.||:.::||
 Worm   123 ENYKKPVLGWGFVSDTDLSDVIRFPHLTTVIPNSLMLGYAASKMLTTFHWNRVALLYYFSDVKYC 187

  Fly   166 EDVWSPVADLLKDQATKR-NMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229
            ..|.:.:.....|.:|.. |:.|..:....||      :..|        .:.|...:|.||  .
 Worm   188 SGVMNDIEATFNDPSTPNVNIVIKAEIYLNDN------ETTD--------NVFQTVKSRARI--I 236

  Fly   230 LGAANSLV---DFMSSMETAGLFARGEYMVIFVDM--MVYSEREAEKYLRRVDQITFM------- 282
            |....:.|   |::..:.|..:.. .||:.|.:.|  :.:..:.:      :.:.||.
 Worm   237 LWCTQTSVEKRDYLIKIATHDMIG-DEYVHIMLSMRNVAFGTQTS------LGKPTFSQSGLTPI 294

  Fly   283 --SNCHSTENFNQMARS------LLVVASTPPTKDYIQF-TKQVQKYSSKPPFNLEIPRLFVESN 338
              |....|:.|.:||:.      :|.|.|....|.|::: .|.:.|....||.|.........:
 Worm   295 WESFTEGTDGFEKMAKQAATRMFVLDVNSEVADKKYLEYMQKNIIKAVQSPPMNCSTVECMTAN- 358

  Fly   339 FSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTD-DVI---FEVASNGTRVIDTIIKNRTYMS 399
             :..:..||.:|:|.|.||..|:......:..|..| ||:   |..:..|......|..|.|.|.
 Worm   359 -TTIMGGYARHLFDVVYLYGIALTHTNSTDPAVYGDVDVLVHQFVTSFQGMTGHVVISPNLTRMP 422

  Fly   400 ITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVP-VAYFHQGEEHPEYKLINGSIDW 463
            |      ...|| ...::..:|.....:.||       .||| |..|::.|         |...|
 Worm   423 I------FQLYG-LNSDYDQVALVDFTYTNS-------VMVPNVTLFYKDE---------GGAVW 464

  Fly   464 P-SGGEKPADEPMCGFANELC-----KKDDTHYTSTVAAVVLGVLLFCSGVITM---------SI 513
            . .|..:|.|.|:|||..:.|     ::........:|.:||.||:...|.:.:         .|
 Worm   465 SYYGHSRPLDIPICGFLGKSCPVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARI 529

  Fly   514 YRKWKI--------ELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTST 570
            ..:|::        |.::.|          ||.|...:.|:||    :|....|....:.|..:.
 Worm   530 NAEWQVPFAKLIESEKQVRG----------KGASRRSLQSAPS----ISTGHSGVTTVSDFCENY 580

  Fly   571 GRLRGAVVRIKELKFP----RKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCA 631
            ..:......:...|:.    .|.|..|.:.     :|:|.|:|||.|||.|::....:.||..|:
 Worm   581 TMMMYEKEMVLTAKYQYTHLTKADKERFVK-----MRKLDHENINRFIGLSIDSAHFISVTKLCS 640

  Fly   632 KGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL 696
            :|||.||:...:..:|..|:..:|.|:.||:.|:|.:.|..||||:|:.|:|...|.:::.::|:
 Worm   641 RGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGM 705

  Fly   697 HELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQ---KGDVYAFAIIMYEIFSRKGPFGQIN 758
            ..|   .|.::..:    :..||.|||:||..:..||   ..|:|:||||..||.::|..:..::
 Worm   706 DNL---VEEQTPPK----KRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILD 763

  Fly   759 FEP--KEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRL 821
            .:.  :|||..|||   .|..|.|||:  |.:.......::|.::|||||.||:||....|.:::
 Worm   764 RKEDCEEIVYNVKK---GGLFPIRPEI--ITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQM 823

  Fly   822 KKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQG 886
            |.:...:..|:||.:..|:|:|.:.||:.:.|||:.|..||.|.:.||.||||:.|||:|..||.
 Worm   824 KGLVSKQKTNLMDHVFNMLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQT 888

  Fly   887 VEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVS 951
            |||..:|.||::|||:|.||.::::.:|.|.||.|||||:.||.||..:.|||||:|||.|:.||
 Worm   889 VEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVS 953

  Fly   952 GLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFG 1016
            |||.:||..|..:|..|:|:.:...|...|.|.|.|.::||||:::||.|||||||:||||||||
 Worm   954 GLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFG 1018

  Fly  1017 DTVNTASRMESNGEALKIHISNKC-KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080
            |||||||||||||:...||::|.. .|........|.|..||.|.:||||.:.|:|:.|......
 Worm  1019 DTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGVMETFWVHGRFGEME 1083

  Fly  1081 QKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSL 1141
            ..:|..:.:...|..:..|..|  ||.|...|            |.|:|...:.|...:.:
 Worm  1084 PTELRSISNRSTPPVTNDRWIP--NPSSSHGS------------RPSSVYDPLQGHQKFKM 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	92/472 (19%)
		PK_GC-A_B	543..827	CDD:270944	90/292 (31%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	103/192 (54%)
gcy-1	NP_496039.1	PBP1_NPR_GC-like	35..451	CDD:380575	89/465 (19%)
		Protein Kinases, catalytic domain	555..821	CDD:473864	89/286 (31%)
		HNOBA	<839..883	CDD:462234	21/43 (49%)
		CYCc	862..1051	CDD:214485	103/188 (55%)