DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and phlp-2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	1109	Identity:	192/1109 - (17%)
Similarity:	347/1109 - (31%)	Gaps:	335/1109 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 DVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLG 231
            :.|     |.:.|..:::   ||..:..:......||:|:               |..|:.:...
Worm   218 EAW-----LTRAQQVEKS---NHVDASDEQLTLIPEQILN---------------NEARVQILNL 259

  Fly   232 AANSLVD---FMSSMETAGLFARGEYMVIFVDMMVYSEREAEKY------LRRVDQITFMSN--- 284
            ..|||:.   ...||...| :....|.|..:.::..|..:...:      |..:.|:...||
Worm   260 RRNSLISRPPTEKSMAPLG-YIDDLYRVHSLQVIDLSANQILSFPIQLTLLSHLRQLNLSSNYIS 323

  Fly   285 -----CHSTENFNQMARSLLVVASTPPTKDYIQFTKQV----QKYSSKPP--FNLEIPRLFVESN 338
                 |.:......:..|...:.:.|.:...:|..:.:    .::|..||  |:|.:....:..|
Worm   324 SVPSECSNMRRLQYLNLSNNQLDTLPDSISELQNLQSLDISFNQFSQIPPCLFHLTLEMWRLAGN 388

  Fly   339 FSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLT------DDVIFEVASNGTRVIDTIIKNRTY 397
            ..:.|..........:.|....:|...|.:...:|      :.:|..|.....|.:..|...|..
Worm   389 NIEKIDRVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMISTVHLTNLRFLKVIHCERLQ 453

  Fly   398 MS---ITGSKIKIDQYGDSE-----------GNFSVLAYKPHKWNNSNNMP-----C-------- 435
            :|   ::|..: ...|.|..           .|...|:.   .:|:..|:|     |
Worm   454 LSSLHLSGESL-THVYADHNLLDSLVVMPLPQNLQTLSL---SFNHFRNLPDWISDCPNLTFLRA 514

  Fly   436 -NYHMV--PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAV 497
             |..:|  |...|:.......:..||.....|..||:...|.:..:.|:|... ..|:.|.:..
Worm   515 NNNSLVALPERIFYSQSLRSIFAFINEIEHIPDFGEENCLETLILYKNKLSSL-PKHFFSILPR- 577

  Fly   498 VLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRW 562
             |..|...|..|.:..|                       :.|    ||..::.::       |.
Worm   578 -LRQLNISSNFIELLPY-----------------------FDG----SSFCRLQIL-------RC 607

  Fly   563 TNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVT 627
            .|.::|...  ...:|.:|.||                 :.:|.|:.:|||..:::....:|
Worm   608 ANNYLTENS--VPVIVNMKHLK-----------------IIDLSHNRLNSFDDSALSSLELL--- 650

  Fly   628 DYCAKGSLYDIIENEDIKLDDLFIASLIHDL----IKGMIYIHNSQLVYHGNLKSSNCVVTSRWM 688
                          ||:.|....:..|...|    ...::..|::|||:....::||
Worm   651 --------------EDLNLSSNRLTRLADCLALLPCLQVLRAHSNQLVHVPEFRASN-------- 693

  Fly   689 LQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGP 753
                  .||.:...:.|.|:|..|      ::||..||:                 :::....|.
Worm   694 ------QLHTIDVSSNNISLGTLQ------FKAPPNLRH-----------------FDVTCNSGD 729

  Fly   754 FGQINFEPKEIVDYVK----------------KLPLKGEDPFRPEVESIIEAESCPDYVLACIRD 802
            |...|| |:....:.|                ::.:.|....:.:               .|||.
Worm   730 FDTENF-PENAKMHSKMNTINISEGSQNLFGFQIGVSGSRGMKNK---------------QCIRQ 778

  Fly   803 CWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKY--ANNLEDIVTERTRLLCEEKMKT 865
            ...|            |....:.||....:...:...|..|  .|...||.:...|..||...:.
Worm   779 VRVE------------NTFGFIDGGSNSYMSSSICRFMTSYLKENVSMDIRSILLRCHCELGEEG 831

  Fly   866 EDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDR 930
            |.|...::...|.||               .:..:.....:|..|.:..|:::  :|..|.:.|
Worm   832 ERLGASVMIIRVHEK---------------RLEIASTGTMSAAIARNQKLKMI--INGRYEIDD- 878

  Fly   931 IIRGYDVYKVETIGDAYMVVSGLPIKNG----DRHAGEIASMALEL-LHAVKQHRIAHRPNETLK 990
                 |.|  ..|.:|:..|......||    .|..|..::..:.| .|:.:..::    ||.::
Worm   879 -----DEY--SRIREAHGFVDEENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQL----NEQIE 932

  Fly   991 LRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGG--GYIT 1053
               |:        :||..|....|..|.:|  |...:|...:.:....:.:|.....||  ..:.
Worm   933 ---GL--------IVGNNMIWNMLSIDDLN--STFHNNRSPIVVAKKIQDQLQSYDYGGNSNILV 984

  Fly  1054 EKRGLVNMKGKGDVVTWWLTGANENAIQKKL-VDMMD--------------------MPPPL--- 1094
            .:|....|...|     :.|.:.:|.:...: :..:|                    :|||:
Worm   985 LRRIKPQMTFNG-----FSTSSTKNQVTPDIAIPKIDEQLVLAVPALILPEYHPSPPVPPPIPAI 1044

  Fly  1095 -FSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQST--------VPRAMDGESTYSLQGSVRESPR 1150
             ...|...|...|.|..|.:.:.|. ....|:.||        :.|.....||.|.:....|:..
Worm  1045 RHRTPSPPPPPLPSSTPPPVSSEHE-EINVRQSSTLSGGYTLSIDRFYSSSSTVSSRKQFNETRD 1108

  Fly  1151 MVSK 1154
            ::||
Worm  1109 LLSK 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	56/336 (17%)
		ANF_receptor	48..412	CDD:279440	46/276 (17%)
		PK_GC-A_B	543..827	CDD:270944	48/303 (16%)
		HNOBA	<835..881	CDD:285003	12/47 (26%)
		CYCc	860..1052	CDD:214485	37/198 (19%)
		Guanylate_cyc	887..1074	CDD:278633	34/193 (18%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	5/35 (14%)
		leucine-rich repeat	254..288	CDD:275380	8/34 (24%)
		PLN00113	283..>718	CDD:331614	91/531 (17%)
		leucine-rich repeat	289..311	CDD:275380	2/21 (10%)
		leucine-rich repeat	312..334	CDD:275380	4/21 (19%)
		leucine-rich repeat	335..357	CDD:275380	2/21 (10%)
		leucine-rich repeat	358..379	CDD:275380	4/20 (20%)
		leucine-rich repeat	380..440	CDD:275380	8/59 (14%)
		leucine-rich repeat	441..485	CDD:275380	7/44 (16%)
		leucine-rich repeat	486..508	CDD:275380	5/24 (21%)
		leucine-rich repeat	509..534	CDD:275380	4/24 (17%)
		leucine-rich repeat	554..577	CDD:275380	5/23 (22%)
		leucine-rich repeat	578..602	CDD:275380	8/50 (16%)
		leucine-rich repeat	603..625	CDD:275380	4/30 (13%)
		leucine-rich repeat	626..649	CDD:275380	7/39 (18%)
		leucine-rich repeat	650..672	CDD:275380	6/38 (16%)
		leucine-rich repeat	673..694	CDD:275380	6/34 (18%)
		PP2Cc	754..985	CDD:214625	52/299 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900