DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Npr1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	1142	Identity:	404/1142 - (35%)
Similarity:	602/1142 - (52%)	Gaps:	182/1142 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPN------- 66
            ||||...:...|.|.:.|||..:..||..........:..|:.:||..|...|:|||.
Mouse    14 LLLLPPLLLLRSGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVL 78

  Fly    67 -----------------VYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQS 114
                             ..:||:|..:.                  |...|| |..|..|.|.:.
Mouse    79 GSSENAAGVCSDTAAPLAAVDLKWEHSP------------------AVFLGP-GCVYSAAPVGRF 124

  Fly   115 R---NIPMISYKCA--------EYRASAIPTFARTEPPDTQVVKSLLALLRYYAW-NKFSILYED 167
            .   .:|:::....        ||   |:.|  ||.|...::...:.||.|...| ::..:||.|
Mouse   125 TAHWRVPLLTAGAPALGIGVKDEY---ALTT--RTGPSHVKLGDFVTALHRRLGWEHQALVLYAD 184

  Fly   168 -------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTR 225
                   .:..|..|......:.|:|:|| |.|::.            ...::.:|::....:.|
Mouse   185 RLGDDRPCFFIVEGLYMRVRERLNITVNH-QEFVEG------------DPDHYTKLLRTVQRKGR 236

  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTEN 290
            :.....:.::..:.|.....|||... :|:...:|:...|.:.|:..:.|       ......:.
Mouse   237 VIYICSSPDAFRNLMLLALDAGLTGE-DYVFFHLDVFGQSLQGAQGPVPR-------KPWERDDG 293

  Fly   291 FNQMAR-----SLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYL 350
            .::.||     :.::....|...:|::|.||::..:.| .||      |...:..|  :|..|..
Mouse   294 QDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADK-KFN------FTMEDGLK--NIIPASF 349

  Fly   351 YDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEG 415
            :|.:.||..||.:.|.:...|          ::|..:... :.||::..:|| .:|||:.||.:.
Mouse   350 HDGLLLYVQAVTETLAQGGTV----------TDGENITQR-MWNRSFQGVTG-YLKIDRNGDRDT 402

  Fly   416 NFSVLAYKPH--------KWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPAD 472
            :||:....|.        .:|.::.     .::.|:      ||..|        ||. |..|.|
Mouse   403 DFSLWDMDPETGAFRVVLNFNGTSQ-----ELMAVS------EHRLY--------WPL-GYPPPD 447

  Fly   473 EPMCGFANE--LCKKDDTHYTSTVAAVVLGVLLFCSG-VITMSIYRKWKIELEIEGLLWKI---- 530
            .|.|||.||  .|.:|  |:::.....::|.|...|. :::..||||.::|.|:...||::
Mouse   448 IPKCGFDNEDPACNQD--HFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWED 510

  Fly   531 -DPNEIKGYSGNEIVSSPSKVSLMS-AQSYGSRWTN----QFVTSTGRLRGAVVRIKELKFPRKR 589
             .|:.::    ..:.|:.|:::|.. ..:|||..|.    |....|...:|.:|.:|.:.  |||
Mouse   511 LQPSSLE----RHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN--RKR 569

  Fly   590 -DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIAS 653
             :::|:::.|::.:|:::::::..|:||..:|..|.::|:||.:|||.||:|||.|.||.:|..|
Mouse   570 IELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYS 634

  Fly   654 LIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQL 718
            |.:|::|||:::||..:..|||||||||||..|::|::||:||...|   :.|....|..:..:|
Mouse   635 LTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQGHTLFAKKL 696

  Fly   719 WRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGED- 777
            |.||||||   ....|||.||||:|.||:.||..|.|.|  ..::..||||::.|    .:||.
Mouse   697 WTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERV----TRGEQP 757

  Fly   778 PFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEK 842
            ||||.    ::.:|..:.:...::.||||||:|||.|..||..|:|.....:.||:|.::..||:
Mouse   758 PFRPS----MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQ 818

  Fly   843 YANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTA 907
            ||||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||||||
Mouse   819 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTA 883

  Fly   908 MSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALEL 972
            :||||||:|||..||||||.||.:|..:|||||||||||||||||||::||..||.|:|.|||.|
Mouse   884 LSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALAL 948

  Fly   973 LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            |.||:..||.|||.|.|:||||:|||||.||||||.||||||||||||||||||||||||:||:|
Mouse   949 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLS 1013

  Fly  1038 NKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            ::.|..|::. .|:..|.||.|.|||||.|.|:||.|
Mouse  1014 SETKAVLEEF-DGFELELRGDVEMKGKGKVRTYWLLG 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	93/474 (20%)
		ANF_receptor	48..412	CDD:279440	81/411 (20%)
		PK_GC-A_B	543..827	CDD:270944	115/295 (39%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	132/191 (69%)
		Guanylate_cyc	887..1074	CDD:278633	130/186 (70%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380	95/491 (19%)
		ANF_receptor	50..410	CDD:279440	85/425 (20%)
		PK_GC-A_B	530..803	CDD:270944	112/285 (39%)
		TyrKc	543..797	CDD:197581	106/266 (40%)
		HNOBA	<812..857	CDD:285003	25/44 (57%)
		CYCc	836..1025	CDD:214485	131/189 (69%)
		Guanylate_cyc	863..1049	CDD:278633	130/186 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3594
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.660