DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and gcy-22

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_508018.2	Gene:	gcy-22 / 180365	WormBaseID:	WBGene00001547	Length:	1058	Species:	Caenorhabditis elegans

Alignment Length:	1145	Identity:	367/1145 - (32%)
Similarity:	554/1145 - (48%)	Gaps:	213/1145 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VLTVGYLTA--LTGDLKTRQGLA-ISGALTMALDEVNKDPNLLPNV-YLDLRW---NDTKGDTVL 82
            ||.||:|.|  .|.:|....|.. ::|||.:|...: .:..|||.. .::|.|   |..:.|
Worm    25 VLQVGFLAANDNTTELAPFIGWGQVAGALGVAWSRI-VEYGLLPGYETMNLTWVLTNCREAD--- 85

  Fly    83 ATKAITEMI--CDGIA-TIFGPEGPC----YVEAIVSQSRNIPMISY---------KCAEYRASA 131
               |:..:|  .:|.| .:.||  ||    .|...|::..:.|:|.:         ...||
Worm    86 ---AVGSVINYAEGHAHVVLGP--PCVRPAQVAGSVAKYLDFPLILWGPPFDSSLLNQFEY---- 141

  Fly   132 IPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY----EDVWSPVADLLKD----QATKRNMTIN 188
             ||.|.|.........||:.||.||.|.:.:::|    .|:......|:.|    .....|:||.
Worm   142 -PTIASTTSSTLYQATSLIRLLEYYKWTEIALIYYVARSDLIPRCTPLISDFEGLVNNNDNLTIT 205

  Fly   189 HKQ--SFIDNR----------------VKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANS 235
            :::  |.|.|.                :.|.|.  |..|......:.:|.|:... ||::.|.:.
Worm   206 YRRQMSVITNTSYATALRNLKELARVVIVCLES--DEARRNLMISISENGMDGDE-YVYIMAESR 267

  Fly   236 LVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLV 300
            ...|.||      |..|            ::.:.:..||...:...|.|    :.:|
Worm   268 RAGFASS------FWNG------------TDGKNDLALRAARKFLVMDN----QKYN-------- 302

  Fly   301 VASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKML 365
                    |...|.::|:...|:|||:  .|..   :|....:| ....|.|::.|||:|:::.:
Worm   303 --------DTTTFVQEVRAAFSRPPFS--CPNC---TNIDPTVS-QVGPLGDALLLYAYALNRSI 353

  Fly   366 REETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYG-----------DSEGNFSV 419
            .......|.....|||           |...::..|| |:.|:|..           ||.....:
Worm   354 ATGNPNPTGTEFCEVA-----------KGMEFLGFTG-KVIINQNSTRTPLFVVYNLDSTDKEMI 406

  Fly   420 LAYKPHKWNNSNN---MPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPS-GGEKPADEPMCGFAN 480
            :.......::|.:   ...||::..||...|              .|.: ||..|...|:|||..
Worm   407 VMQITEDLDDSKDPVASSVNYYITLVATPAQ--------------IWDTWGGTVPLSTPICGFTG 457

  Fly   481 ELCKKDDTHYTSTVAAVVLG----VLLFCSGVITMSIY--RKWKIELEIEGLLWKIDPNEIKGYS 539
            ..|.|.   :|....|::||    .|:....||:..::  |..:.|.|....||::        .
Worm   458 TDCPKS---FTDQYLAIILGCTAAALVLIIAVISTIVFLVRSKRQEEERLNQLWQV--------H 511

  Fly   540 GNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELK---------------FPRKR 589
            .:.:|..|.|.::.|::|..|..|    |||      .|.|...|               ..||.
Worm   512 FSSLVKPPQKNTMHSSRSLQSTVT----TST------KVTINSKKDTERHSFYFLNNDSVVARKH 566

  Fly   590 DISREIMKE----MRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLF 650
            :......|.    .|.:|.:.:||:..|||.|::...::.:..||::|||.|:|....:::|..|
Worm   567 NFRATFTKNDRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFF 631

  Fly   651 IASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYR 715
            ..||:.|:...:.|:|:|.:..||.|.||.|:|..||.::|:.|||..::|.       |.:..|
Worm   632 KYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQY-------EVKEQR 689

  Fly   716 NQLWRAPELLRN-HIHGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGED 777
            :.|..|||.:|: ::..:::.|:|:||||..|:.::|..:...|  |:.:|:|..:||   .|..
Worm   690 DFLHTAPEHIRDTNLPITKEMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKK---GGRS 751

  Fly   778 PFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEK 842
            |.||.:|:..|.......:   :||||.|:|::||....|:..:|.|...::.|:||.:..::|:
Worm   752 PPRPSLETEDEHNGSMSLL---VRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVLEQ 813

  Fly   843 YANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTA 907
            ||:||||.|..|.:.|.|||.:::.||:||||:.|||||.:||.|||.::|.|||:|||:|.||.
Worm   814 YASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTT 878

  Fly   908 MSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALEL 972
            :::..|||||||.||||||.||.||..:||||||||||.|:.|||||.:||:.||.||:||:..|
Worm   879 LASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSL 943

  Fly   973 LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            |.|:|..|:.|.|.|.:.:|:|:||||||.||||:||||||||||:|||||||||||:..::|||
Worm   944 LKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHIS 1008

  Fly  1038 NKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANE 1077
            .:|...|.::.|||.||.||.|.:||||.|.|.||...:|
Worm  1009 TECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLLTDDE 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	106/481 (22%)
		ANF_receptor	48..412	CDD:279440	91/420 (22%)
		PK_GC-A_B	543..827	CDD:270944	91/305 (30%)
		HNOBA	<835..881	CDD:285003	22/45 (49%)
		CYCc	860..1052	CDD:214485	118/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	116/186 (62%)
gcy-22	NP_508018.2	Periplasmic_Binding_Protein_Type_1	28..408	CDD:299141	100/452 (22%)
		ANF_receptor	48..399	CDD:279440	91/423 (22%)
		PKc_like	553..795	CDD:304357	77/254 (30%)
		HNOBA	<791..852	CDD:285003	27/60 (45%)
		CYCc	831..1023	CDD:214485	118/191 (62%)
		Guanylate_cyc	858..1044	CDD:278633	115/185 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010