Protein Alignment Gyc76C and gcy-22

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_508018.2
• Gene: gcy-22 / 180365
• WormBaseID: WBGene00001547
• Length: 1058
• Species: Caenorhabditis elegans
• Alignment Length: 1141
• Identity: 366/1141 - (32%)
• Similarity: 556/1141 - (48%)
• Gaps: 205/1141 - (17%)

  Fly    25 VLTVGYLTA--LTGDLKTRQGLA-ISGALTMALDEVNKDPNLLPNV-YLDLRW---NDTKGDTVL 82
            ||.||:|.|  .|.:|....|.. ::|||.:|...: .:..|||.. .::|.|   |..:.|
 Worm    25 VLQVGFLAANDNTTELAPFIGWGQVAGALGVAWSRI-VEYGLLPGYETMNLTWVLTNCREAD--- 85

  Fly    83 ATKAITEMI--CDGIA-TIFGPEGPC----YVEAIVSQSRNIPMISYKCAEYRASAI-----PTF 135
               |:..:|  .:|.| .:.||  ||    .|...|::..:.|:|.:. ..:.:|.:     ||.
 Worm    86 ---AVGSVINYAEGHAHVVLGP--PCVRPAQVAGSVAKYLDFPLILWG-PPFDSSLLNQFEYPTI 144

  Fly   136 ARTEPPDTQVVKSLLALLRYYAWNKFSILY----EDVWSPVADLLKD----QATKRNMTINHKQ- 191
            |.|.........||:.||.||.|.:.:::|    .|:......|:.|    .....|:||.:::
 Worm   145 ASTTSSTLYQATSLIRLLEYYKWTEIALIYYVARSDLIPRCTPLISDFEGLVNNNDNLTITYRRQ 209

  Fly   192 -SFIDNR----------------VKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDF 239
             |.|.|.                :.|.|.  |..|......:.:|.|:... ||::.|.:....|
 Worm   210 MSVITNTSYATALRNLKELARVVIVCLES--DEARRNLMISISENGMDGDE-YVYIMAESRRAGF 271

  Fly   240 MSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVAST 304
            .||      |..|            ::.:.:..||...:...|.|    :.:|
 Worm   272 ASS------FWNG------------TDGKNDLALRAARKFLVMDN----QKYN------------ 302

  Fly   305 PPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREET 369
                |...|.::|:...|:|||:  .|..   :|....:| ....|.|::.|||:|:::.:....
 Worm   303 ----DTTTFVQEVRAAFSRPPFS--CPNC---TNIDPTVS-QVGPLGDALLLYAYALNRSIATGN 357

  Fly   370 RVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYG-----------DSEGNFSVLAYK 423
            ...|.....|||           |...::..|| |:.|:|..           ||.....::...
 Worm   358 PNPTGTEFCEVA-----------KGMEFLGFTG-KVIINQNSTRTPLFVVYNLDSTDKEMIVMQI 410

  Fly   424 PHKWNNSNN---MPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPS-GGEKPADEPMCGFANELCK 484
            ....::|.:   ...||::..||...|              .|.: ||..|...|:|||....|.
 Worm   411 TEDLDDSKDPVASSVNYYITLVATPAQ--------------IWDTWGGTVPLSTPICGFTGTDCP 461

  Fly   485 KDDTHYTSTVAAVVLG----VLLFCSGVITMSIY--RKWKIELEIEGLLWKIDPNEIKGYSGNEI 543
            |.   :|....|::||    .|:....||:..::  |..:.|.|....||::        ..:.:
 Worm   462 KS---FTDQYLAIILGCTAAALVLIIAVISTIVFLVRSKRQEEERLNQLWQV--------HFSSL 515

  Fly   544 VSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELK---------------FPRKRDISR 593
            |..|.|.::.|::|..|..|    |||      .|.|...|               ..||.:...
 Worm   516 VKPPQKNTMHSSRSLQSTVT----TST------KVTINSKKDTERHSFYFLNNDSVVARKHNFRA 570

  Fly   594 EIMKE----MRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASL 654
            ...|.    .|.:|.:.:||:..|||.|::...::.:..||::|||.|:|....:::|..|..||
 Worm   571 TFTKNDRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSL 635

  Fly   655 IHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLW 719
            :.|:...:.|:|:|.:..||.|.||.|:|..||.::|:.|||..::|.       |.:..|:.|.
 Worm   636 MRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQY-------EVKEQRDFLH 693

  Fly   720 RAPELLRN-HIHGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRP 781
            .|||.:|: ::..:::.|:|:||||..|:.::|..:...|  |:.:|:|..:||   .|..|.||
 Worm   694 TAPEHIRDTNLPITKEMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKK---GGRSPPRP 755

  Fly   782 EVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANN 846
            .:|:..|.......:   :||||.|:|::||....|:..:|.|...::.|:||.:..::|:||:|
 Worm   756 SLETEDEHNGSMSLL---VRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVLEQYASN 817

  Fly   847 LEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAE 911
            |||.|..|.:.|.|||.:::.||:||||:.|||||.:||.|||.::|.|||:|||:|.||.:::.
 Worm   818 LEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASR 882

  Fly   912 STPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAV 976
            .|||||||.||||||.||.||..:||||||||||.|:.|||||.:||:.||.||:||:..||.|:
 Worm   883 CTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAI 947

  Fly   977 KQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCK 1041
            |..|:.|.|.|.:.:|:|:||||||.||||:||||||||||:|||||||||||:..::|||.:|.
 Worm   948 KTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECM 1012

  Fly  1042 LALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANE 1077
            ..|.::.|||.||.||.|.:||||.|.|.||...:|
 Worm  1013 KFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLLTDDE 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	105/477 (22%)
		PK_GC-A_B	543..827	CDD:270944	91/305 (30%)
		HNOBA	<833..881	CDD:462234	24/47 (51%)
		CYCc	860..1052	CDD:214485	118/191 (62%)
gcy-22	NP_508018.2	PBP1_NPR_GC-like	27..411	CDD:380575	99/452 (22%)
		Protein Kinases, catalytic domain	553..795	CDD:473864	77/254 (30%)
		HNOBA	<791..852	CDD:462234	27/60 (45%)
		CYCc	831..1023	CDD:214485	118/191 (62%)