DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and gcy-32

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	714	Identity:	178/714 - (24%)
Similarity:	294/714 - (41%)	Gaps:	191/714 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 SGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVL------LFCSGVITMSIYRKWKIELEI 523
            ||.|...:..|    |......||:......::||.|.      ::...:||.|:...|
Worm    29 SGFESGKENIM----NHYYSDTDTYVLVDSVSLVLKVTKDQVWEMYGGFLITYSMEIGW------ 83

  Fly   524 EGLLWKIDPNEIKGYSGN---------EIVSSPSKVSLMSAQSY-------GSRWTNQFVTSTGR 572
            :.|:..:.|| :||:..|         .:|...:    :...|:       |:...:.|   |||
Worm    84 DELVRSMSPN-LKGFLDNLDSLHYFIDHVVYKAN----LRGPSFRCEETPDGTLLLHYF---TGR 140

  Fly   573 ------LRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYC- 630
                  ::|.|..:.:..|    |:...::.:.|..|.:..:|     |..||...:.|:.:..
Worm   141 PGLYHIVKGVVKEVAKRVF----DLDITLVVQGRTQRSVHMNN-----GERVEEHVVFLINNLSE 196

  Fly   631 ----AKGSLYDIIENEDIK----LDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRW 687
                ::||...::.:.:..    :||....|| .|..|.        |.||..:..| |
Worm   197 PRRDSEGSEVSLLTSTNANFPTIVDDTLGISL-DDFSKA--------LPYHFVIDES-C------ 245

  Fly   688 MLQVTDFGLHELRQCAENESIGEHQHYRNQLWR-APELLRNHIHGSQKGDVYAFAIIMYEIFSRK 751
                      :|.||...    .|.|..|:|.: ...:||                 ::||...:
Worm   246 ----------KLVQCGSE----LHNHIPNELLQPGTPILR-----------------IFEINRPQ 279

  Fly   752 GP--FGQI-NFEPKEIVDYVKKLPLK-------GEDPFRPEVESIIEAES--------------- 791
            .|  |..| ||.....|..||..|||       .::..:.|:|::.|..:
Worm   280 IPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATNELTQGHHLKLKGQM 344

  Fly   792 ------------CPDYVLACIRDCWAEDPEERPEFSVIRNRLKKM-RGGKTKNI-------MDQM 836
                        |..||.:.         .|..::.:   ||..| ....|:::       :..:
Worm   345 MLLASKKHIIYLCSPYVTSI---------NELMQYGM---RLTAMPLHDATRDLILLNQQRLSDV 397

  Fly   837 MEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSD 901
            ...::..||| |.:.| .||.|..|:.||:.:|..|||:.:|::|..|:.:|...:: .|:.|.|
Worm   398 EVNLQLEANN-EQLET-MTRELELERQKTDSILKDMLPRRIAQQLLSGEHIEACEHE-ATVMFCD 459

  Fly   902 IVGFTAMSAESTPLQVVNFLNDLYTVFDRI--IRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGE 964
            :..|.....:.:|..:||.||:::...|||  |||  ||||||:.|:||.|||:|....: ||..
Worm   460 LPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRG--VYKVETVSDSYMAVSGIPDYTPE-HAEN 521

  Fly   965 IASMALELLHAVKQ--HRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1027
            :..:||.::...:.  ..::..|   ..||||:|:|.:.|||||...|:|||||:||..||:|||
Worm   522 MCHVALGMMWEARSVIDPVSKTP---FLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLASQMES 583

  Fly  1028 NGEALKIHISNKCKLALDKL--GGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMD 1089
            .|.|.||..|   |.|..|.  .|.:....||.:::|.:|...|::||    .:::|.:.:::|
Worm   584 LGMAGKIQCS---KWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFLT----RSLKKSIWEIID 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	63/344 (18%)
		HNOBA	<835..881	CDD:285003	16/45 (36%)
		CYCc	860..1052	CDD:214485	77/197 (39%)
		Guanylate_cyc	887..1074	CDD:278633	73/192 (38%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	31/159 (19%)
		HNOBA	226..440	CDD:285003	58/274 (21%)
		CYCc	419..608	CDD:214485	77/198 (39%)
		Guanylate_cyc	452..627	CDD:278633	71/184 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810