DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and gcy-33

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	666	Identity:	167/666 - (25%)
Similarity:	287/666 - (43%)	Gaps:	138/666 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 QINFEPKEIVDY---VKKLP---LKGEDPFRPEVESIIEAESCPDYVLACI------------RD 802
            :::.|.|.::|.   ::.||   |:|........|:.:...:|....|..:            .|
Worm   299 KVSLEKKTVMDNEYGLESLPYVTLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDFGESD 363

  Fly   803 CWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTED 867
            |..|         :|...::|         .|.:..|:|......| ::||.||.:.|.|.....
Worm   364 CNRE---------IIMATIQK---------SDTLKTMLENEKRRSE-VLTEMTREISEAKKTART 409

  Fly   868 LLHRMLPQSVAEKLTMGQGVEPV-SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRI 931
            ||.:|:|..||:.:.....|:.. :::.|:|.|..:..|:.:|......:|||.||.:|:..|.|
Worm   410 LLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDFSKISLFIEAFEVVNLLNTIYSHLDSI 474

  Fly   932 IRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRI-AHRPNETLKLRIGM 995
            :..:.||||||||::||:.:|.|.:: |..|..::...||::..:|.... :|...:.:.::.|:
Worm   475 VDTHGVYKVETIGESYMISAGCPYRD-DYDAEMVSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGI 538

  Fly   996 HTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEA-LKIHISNKCKLALDK-LGGGYITEKRGL 1058
            .|||||.||||:..||||||||||||||||||:.:. :.|.|..:.|..::| ..|.:..:.:|.
Worm   539 FTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGN 603

  Fly  1059 VNMKGKGDVVTWWLTGANENA-------IQKKLV-------DMMDMPPPLFSRPRKSPKLNPDSR 1109
            |.:|||||:..:.:......|       ::||:|       :::|..    :...:|..|:..|.
Worm   604 VFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLDED----NEGHRSSALSRMSL 664

  Fly  1110 QPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSKRDR--------DRERPPING 1166
            ..||.:     :.|||.|     :.| |...|..::.::..:.||...        :..|||.
Worm   665 GESIDS-----SSSRRGS-----LSG-SQLELNKTIAQTIELTSKASAALDLNMQDENNRPPT-- 716

  Fly  1167 LGAGH-------------FVGGALLESAQASLSTLNHSETNETNCDMDGGSGGVSGSGSGLVRQP 1218
            ..|.|             ....:.|.|:..::|.:      ||:.|.||.:...:.|.   :::.
Worm   717 WSASHSQDIRKPRKTESKITLNSRLSSSDLAVSRV------ETSKDSDGETPRPTSSE---LKEV 772

  Fly  1219 NAL-HKPLAMVRPHRIISAAQ---LPQLGDNDDDSADTLL-------RESRSLDPMPMQQLRKRH 1272
            |.: .:.||..:.....:..:   :.::|::....|.:||       ..:.|...||...: ...
Worm   773 NRIREEALAQEKEEERTTKEENQKIEEVGEDHVSEATSLLDSEVSHGDNNISFSQMPSDSI-PHE 836

  Fly  1273 DRVKLP---PS---------KLSKNNSR----SLDTGVSLISGNPNGEVH-SSQLDLDNE----- 1315
            ||..||   ||         ||.|.:|.    |||...: :|..|..... .:|.||:.|
Worm   837 DRTSLPSATPSEIGDAISKKKLEKEDSNSSMSSLDERTT-VSAKPTTTRRLLNQKDLEKEKKRSS 900

  Fly  1316 MTANPVDATDGYDDEL 1331
            |..:.|.::..:...:
Worm   901 MAGSSVTSSSAHSHSI 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	15/88 (17%)
		HNOBA	<835..881	CDD:285003	15/45 (33%)
		CYCc	860..1052	CDD:214485	73/195 (37%)
		Guanylate_cyc	887..1074	CDD:278633	72/190 (38%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902
		HNOBA	204..423	CDD:369471	31/142 (22%)
		CYCc	402..598	CDD:214485	73/196 (37%)
		COG5134	<595..744	CDD:227463	32/165 (19%)
		TDA11	<710..>898	CDD:293689	43/200 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910