Protein Alignment Gyc76C and daf-11

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_505960.3
• Gene: daf-11 / 179605
• WormBaseID: WBGene00000907
• Length: 1077
• Species: Caenorhabditis elegans
• Alignment Length: 1177
• Identity: 284/1177 - (24%)
• Similarity: 493/1177 - (41%)
• Gaps: 292/1177 - (24%)

  Fly   138 TEPPDTQVVKSLLALLRYYAWNKF-SILYEDVW-----------SPVADLLKDQ--ATKRNMTIN 188
            |..|. .:.::|::|||.:.|.:. ::|.|:.:           |.:.|:.::.  |.|..:.|.
 Worm    42 TRSPQ-NLAQNLVSLLRGFEWGQVGAVLCEECYEGDELASEIYFSTIEDIFENNNIALKETVRIG 105

  Fly   189 HKQSF--IDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLG-AANSLVDFMSSMETAGLFA 250
            .:::.  |.:.:...|.                  :...|.:||| ..|...:||::| :...:.
 Worm   106 KRENSVNISDAITIFEP------------------SARVILLFLGNKLNDYTEFMTAM-SMNNYT 151

  Fly   251 RGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTK--DYIQ- 312
            ..||    ..::|.|:...|        :||                        |.|  |.|.
 Worm   152 TEEY----TPVIVISKNSLE--------LTF------------------------PWKENDAIAE 180

  Fly   313 -FTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIY----------AAYLYDSVKLYAWAVDKMLR 366
             |.|.:..|::          .:.:|..|.|:|.|          :..:|:...|..:.:
 Worm   181 LFDKAIIVYNN----------CYDKSKISSFLSSYSFSTIEETIISLQMYEGYHLLGYYL----- 230

  Fly   367 EETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNN 429
              ...:|:..:|........:        :.|||.|  .:|.|:..|.....:.||..  .|..|
 Worm   231 --YTAITNTTLFNYVQPEKAI--------SSMSIPGPFGEIFINSNGQRIAGYDVLVV--DKSLN 283

  Fly   430 SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTV 494
            |||.     ::|:......::.|:...:|..::..|..|...|.|:|||..|:|  |.|.....:
 Worm   284 SNNF-----IMPLGTISTDKKCPDQACLNFVLNSTSSFEPLKDVPLCGFHGEIC--DQTGVIIAI 341

  Fly   495 AAVVLGVLLF-----------CSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPS 548
             ||::||||.           |:|....||...|.|..:....:      ::....|::.:|..|
 Worm   342 -AVIMGVLLMFIIILTTIRKCCNGSKGRSISNPWVIPFQDVRFI------DLTNTEGSQHMSIQS 399

  Fly   549 -KVSLMSAQSYGSRWTNQFVTSTGR---LRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDN 609
             :.::...|...|....:.:.:..:   |....|...:|::. |.||:  ::.:|:  ..|:|||
 Worm   400 LQRNMEEKQRLQSLARTKHIATVDQVYVLADKYVMRDKLRYD-KIDIN--LLYQMK--SHLQHDN 459

  Fly   610 INSFIGASVE-PTRILLVTDYCAKGSLYDIIENED------IKLDDLFIASLIHDLIKGMIYIHN 667
            :|||:|.::: .:.:.::.:.|.:|||:|.|..::      .:.:.||    :.|::||:.|||.
 Worm   460 LNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLF----LRDILKGLEYIHA 520

  Fly   668 SQLVYHGNLKSSNCVVTSRWMLQVTDFGLHEL--------RQCAENES---IGEHQHY----RNQ 717
            |.:.:||||...||::.|.|:::::.||::.|        :...|:.:   ..|..||    ..:
 Worm   521 SAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKSEELHYFDPAMKK 585

  Fly   718 LWR-----------APELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYV--- 768
            :|:           .|:.       .:|.|:|:|.:|::||..:|....|:...|:|..|.|
 Worm   586 IWKNYADRNERALITPQF-------GKKCDMYSFGVILHEIILKKKFVEQLFDSPREEDDSVLID 643

  Fly   769 -------KKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIR---NRLKK 823
                   .:.||       |.:  |.|.....:.::..:.:|:.   ..||:.::.|   :.:.|
 Worm   644 DENDAIASRFPL-------PII--IPEGIEMHNDLIKMLENCFG---SVRPDIALARKIIDTVLK 696

  Fly   824 MRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVE 888
            |.|    :::|.|::.:..|...|.:.|..||..|.:|:.|.:.||..:||:|||..|..|..|:
 Worm   697 MSG----SLVDLMIKNLTAYTQGLNETVKNRTAELEKEQEKGDQLLMELLPKSVANDLKNGIAVD 757

  Fly   889 PVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGL 953
            |..|:..||.:|||||||::.::|.|::||..|:.:|..||.||.....||:|||||||.|.:||
 Worm   758 PKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDAYCVAAGL 822

  Fly   954 PIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDT 1018
            |:.....|...|..:||.....:....|.|||...|..|.|.::|||.|||:|...|||..||:.
 Worm   823 PVVMEKDHVKSICMIALLQRDCLHHFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEA 887

  Fly  1019 VNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKK 1083
            |..||:|||:|...:|.::...:..|::....::...||...::|.|.::|:||.|.|... |.|
 Worm   888 VILASKMESSGVEDRIQMTLASQQLLEENFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGE-QVK 951

  Fly  1084 LVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAM--DGESTYSLQGSVR 1146
            :|:..:             .||.:                     :.|.|  |||   .|..:..
 Worm   952 VVEFQN-------------DLNDE---------------------LSRIMKKDGE---LLAAATA 979

  Fly  1147 ESP---------RMVSKRDRDRERPPINGLGAGHFVGGALLESAQASLSTLNHS----ETNETNC 1198
            ..|         :::::|..:.||                |:..|.....|...    |.||...
 Worm   980 LKPKDKMTLAKEKVIAERKNEEER----------------LQRQQTLQEALEEHEEEIEMNEVLV 1028

  Fly  1199 DMDGGSG 1205
            |.|.|.|
 Worm  1029 DEDEGEG 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	62/339 (18%)
		PK_GC-A_B	543..827	CDD:270944	75/333 (23%)
		HNOBA	<833..881	CDD:462234	17/47 (36%)
		CYCc	860..1052	CDD:214485	78/191 (41%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_type1	2..289	CDD:471960	61/334 (18%)
		Protein Kinases, catalytic domain	447..695	CDD:473864	63/272 (23%)
		CYCc	729..922	CDD:214485	78/192 (41%)