DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and acy-1

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	597	Identity:	137/597 - (22%)
Similarity:	254/597 - (42%)	Gaps:	158/597 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 KNIMDQMM----EMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPV 890
            |.:.|:::    |:....|:|..:..|...       .:.:..|.:|:|:.        :...|.
Worm   261 KKVADELLKDASELRRPSASNDSNCRTSNA-------TQVDQPLAKMVPEY--------RKFRPF 310

  Fly   891 SYDLVT---IYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSG 952
            :.:|:|   |.|:||.|||.||:..:..::||.||||:..||.:.|...:.|:.|:||.|..|:|
Worm   311 TMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAG 375

  Fly   953 LPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGD 1017
            .| :..|.||.....|.|:::.|::|..|..  .:.:.:|:|:|||.|:.|:||....::.:|.:
Worm   376 CP-EPCDDHACRTVEMGLDMIVAIRQFDIDR--GQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSN 437

  Fly  1018 TVNTASRMESNGEALKIHISN-KCKLALDKLGGGYITEK----RGLVNMKGKG--------DVVT 1069
            .|..|:.|||:|.|.::|:|. ..||    |.|.|..|:    .|.:.|:.:|        .:.|
Worm   438 DVTLANEMESSGVAGRVHVSEATAKL----LKGLYEIEEGPDYDGPLRMQVQGTERRVKPESMKT 498

  Fly  1070 WWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPR--- 1131
            :::.|...:.::::::.:.:                       ::::|  ...|.::||:.:
Worm   499 FFIKGRINDGVEEEVMQVQE-----------------------VESLH--SQKSSKKSTLKQKWA 538

  Fly  1132 ---AMDGESTYSLQGSVRE---SPRM-VSKRDRDRERPP--INGLGAGHFVGGALLES--AQASL 1185
               .|:..::|.::.:.||   |.|: :::|:|..:..|  .|.:        .::|.  ..|||
Worm   539 EKLKMNHTNSYPMRAAAREGGGSLRIKLAERNRSTQLLPKESNSI--------CIMEDNRKSASL 595

  Fly  1186 STL-----NHSETNETNCDMDGGSGG------VSGSGSGLVRQPNALHKPLAMVRPHRIISAAQL 1239
            ..|     |.|.|:..|...:.|..|      |:||.|..::...:              |..||
Worm   596 QALATNNFNGSNTDTNNTYSERGVAGSVSKKSVAGSESNSIKGSRS--------------SGLQL 646

  Fly  1240 PQLGDNDDDSADTLLRESRSLDPMPMQQLRKRHDRVKLPPSKLSKNNSRSLDTGVSLISGNPNG- 1303
             .|.|.:.|     |.....||    ..:...|:...|  ::...:|  :.|..::::.|...|
Worm   647 -SLQDGNSD-----LNSVGGLD----TAISHHHNAASL--TRFDTDN--NFDQRLAMVIGQGEGG 697

  Fly  1304 ------EVHSS---------QLDLDNEMTANPVDATDGYD-DELGLLMRH-----DNGQLPAL-- 1345
                  ..|.|         :.|::.|..|:.||:::.|. .:.|.:.||     ..|:...:
Worm   698 FDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITG 762

  Fly  1346 ------RYSGSF 1351
                  ||||.|
Worm   763 STVNKYRYSGVF 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003	7/49 (14%)
		CYCc	860..1052	CDD:214485	63/195 (32%)
		Guanylate_cyc	887..1074	CDD:278633	66/202 (33%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686
		CYCc	297..469	CDD:214485	63/186 (34%)
		Guanylate_cyc	317..503	CDD:278633	63/192 (33%)
		SDF	<773..982	CDD:294387	1/2 (50%)
		CYCc	1016..1215	CDD:214485
		Guanylate_cyc	1041..1235	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810