Protein Alignment Gyc76C and gcy-29

DIOPT Version :9

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001364597.1
• Gene: gcy-29 / 175116
• WormBaseID: WBGene00007314
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1170
• Identity: 321/1170 - (27%)
• Similarity: 555/1170 - (47%)
• Gaps: 202/1170 - (17%)

  Fly     4 WPFNLLLL----LSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLL 64
            |.|..:.:    :.:.|   |:.:.||.:|.:::      ......:...|.||..::.:...|.
 Worm     6 WNFQFIFVIFCWIPIVV---SDEKIVLKIGSISS------RDNAKMLESILEMAKKKMTEQGVLG 61

  Fly    65 PNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIFGPEGPCYVE----AIVSQSRNIPMISYKC 124
            ..:.:.:...:..|.:.....|..|:. ...:...|||.  |..|    |.::...|||:.:|
 Worm    62 EKLDIQIITVEGCGASFEGVAAAAELYHVQKVDAYFGPY--CSKELSPVATMASYWNIPIFAY-- 122

  Fly   125 AEYRASAIPTFARTEPPDTQVVKSLL---------------ALLRYYAWNKFSIL-------YED 167
                     |....|..:|:|.|:||               |.:.::...|.:|:       :|.
 Worm   123 ---------TATSAEFANTKVYKTLLRTSFQSLNSISEATAAFMAHHNITKAAIVANIGTDSFEK 178

  Fly   168 VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGA 232
            :.|     |:.....|.:|:..:..|  ......:.::|   :||..:|..|.  |..:.:|...
 Worm   179 IQS-----LEKALRSRGITVARRVMF--EEAASAQDLVD---NGYMNELRDNA--RVILPIFSST 231

  Fly   233 ANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEK---YLRRVDQITFMSNCHSTENFNQM 294
            .:....|.::...|.: |..|:  |:::.::.:....|.   |.:...:.....|.::.:.:|..
 Worm   232 RDLSTVFRNATWLANM-ASPEF--IYINPLIVARNSEEPPVFYGKMAQKSIKAENPNTIQIYNSY 293

  Fly   295 ARS--LLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLY 357
            ..|  ||        .:::....|.|             |::::   .|.:..|.| ||:|..::
 Worm   294 GFSDDLL--------NEFLAIFDQNQ-------------RIYID---EKDLFNYVA-LYESFCVF 333

  Fly   358 AWAVDKMLR------EETRVLTD-DVIFEVASNGT--RVIDTIIKNRTYMSITG-SKIKIDQYGD 412
            |...:|.|.      |:.::..| ..::.:|...|  .|:|.:|.:.....:|. |...:|:..|
 Worm   334 AKLTEKYLHSLKEKPEDGKIRIDGKALWNMAVGMTFQGVLDNVIFDNGAERMTSFSAFYVDEKRD 398

  Fly   413 SEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSI---DWPS-GGEKPADE 473
            .....|::        ||.....|. |.||.          .:|:...:   .|.| .|:.|..|
 Worm   399 QIRTVSLI--------NSTVTSKNC-MDPVC----------IELVVSDVVTKFWSSPSGKLPDSE 444

  Fly   474 PMCGFANELCKKDDTHYTST--VAAVVLGVLLFCSGVITMSIYRKWKIELE-IEGLLWKIDPNEI 535
            |.|||..|.|     .||.|  :|..|:.::|    .:.:.|:.:...|.. ::.:.|::..:::
 Worm   445 PECGFREENC-----DYTQTIVIATAVVCIIL----TVFLGIWLRRACETSALDKMPWRVFRDDV 500

  Fly   536 KGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTS---TGRLRGAVVRIKELKFPRKRDI--SREI 595
            :.....::   .|.|||.||.:..|:...:.:.:   .|....||..:.|    ::::|  :||.
 Worm   501 QILDEEQV---KSVVSLNSASTKMSQVETKLIKNHAIVGVNTHAVYDLYE----QRQNIRFTRED 558

  Fly   596 MKEMRLLRELRHDNINSFIGASV-EPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLI 659
            :..:..:::..|||||.|||.|. |.:.:||:..:|::|:|.|:|..|...:|:.|..:.:.|:.
 Worm   559 LILLTKMKQAVHDNINPFIGVSFNEKSELLLLWKFCSRGTLQDVIYCEKFAMDEKFQGAFVRDIT 623

  Fly   660 KGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL---------HELRQC-AENESIGEHQ-- 712
            .|:.|:|:|.:.|||.|...:.::...|||::||:.:         |....| .:||:..:.|
 Worm   624 MGLEYLHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRINCKVDNEAEKQWQKM 688

  Fly   713 ------------HYRNQL------WRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINF 759
                        :.:|:|      |:...:|:.     |:.|:|||.:|:|||..|..|:.
 Worm   689 ASLYVPPEIRTANEKNRLKRMDQKWQGQTILKR-----QQSDIYAFGVIIYEILFRSLPYD---- 744

  Fly   760 EPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKM 824
            |..::.:..:| ..:|:...:|.::.  ..:..|| ::|.::|||::.|:.||  ::.|.||...
 Worm   745 EKVDLTELAQK-AAEGDKIQKPSIQR--NKKLNPD-LIALLQDCWSDQPDMRP--TIRRVRLATE 803

  Fly   825 RGGKTK-NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVE 888
            ...||| |::|.||.|||:||||||.:|.|||:|..|..::.|.||.::||:.||.:|..|:.|.
 Worm   804 IALKTKGNLVDSMMRMMEEYANNLEKLVGERTKLAEEANLRAERLLFQLLPKHVAIELKAGRTVA 868

  Fly   889 PVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGL 953
            |..||..|:.||||||||.:.:.|||::|||.||.||:.||.:|..:|.|||||||||||||||:
 Worm   869 PKMYDSATVMFSDIVGFTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCYKVETIGDAYMVVSGI 933

  Fly   954 PIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDT 1018
            ||:||.||...|:::.|.::..:|...:.||.:..|.:|:|..:|.|.|.||||:.|||||||:|
 Worm   934 PIENGQRHVANISAVTLGIMDLLKVFEVPHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGET 998

  Fly  1019 VNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKK 1083
            ||.|:.|||:||..::.|:...|:.|:.....:|.|.||:.....:.|.||:||||.:|:..:||
 Worm   999 VNIAAVMESSGEGGRVQITETSKILLENEYPEFIIEIRGINKDVKQDDFVTYWLTGKDEDYFKKK 1063

  Fly  1084  1083
             Worm  1064  1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	84/460 (18%)
		ANF_receptor	48..412	CDD:279440	74/405 (18%)
		PK_GC-A_B	543..827	CDD:270944	84/319 (26%)
		HNOBA	<835..881	CDD:285003	24/45 (53%)
		CYCc	860..1052	CDD:214485	92/191 (48%)
		Guanylate_cyc	887..1074	CDD:278633	91/186 (49%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575	78/434 (18%)
		PKc_like	534..804	CDD:419665	77/288 (27%)
		CYCc	840..1033	CDD:214485	92/192 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910