Protein Alignment Gyc76C and gcy-28

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001021600.1
• Gene: gcy-28 / 172051
• WormBaseID: WBGene00020131
• Length: 1276
• Species: Caenorhabditis elegans
• Alignment Length: 1328
• Identity: 413/1328 - (31%)
• Similarity: 616/1328 - (46%)
• Gaps: 361/1328 - (27%)

  Fly     4 WPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGA---LTMALDEVNKDPNLLP 65
            :|||::::|........|.                    |:.:..|   :.:|:.||.|...|.|
 Worm    39 FPFNVIVILPKRESTYDNF--------------------GMTLQKAMPVIDIAVQEVIKAKKLPP 83

  Fly    66 NVYLDLRWNDTK--GDTVL----ATKAITEMICD-------------GIATIFGPEGPCYVEAIV 111
            . :::|.:.|::  .|.:|    ||..:.:..|:             |:||:        .:...
 Worm    84 G-WINLTYWDSRLYEDILLAERHATVGVIQAYCEHRLDAILGFADNYGLATV--------TKVTA 139

  Fly   112 SQSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAW-----NKFSILYEDVWSP 171
            ..:..||:::       .|.:|              |||...:.|.:     ..:.:|.:.::..
 Worm   140 GLNGGIPILT-------TSGMP--------------SLLNSKKEYPFLTRMQGSYRLLADSMYQL 183

  Fly   172 VADLLKDQATKRNMTIN--------HKQSFIDNRVKCCEQMLD-------CCRSGY--------- 212
            :|...:|..:|.|.::|        |.:....|||...::..:       |..|.|
 Worm   184 IAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEK 248

  Fly   213 -------W--------------------YQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFA 250
                   |                    .|.::....::.:.:...:.:::.:.|.:....|:..
 Worm   249 SKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMAT 313

  Fly   251 RGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKD-YIQFT 314
            .|||:.|.:|:...|..| :.::|..|     :|....|...:..|:|..::......| |..|.
 Worm   314 SGEYVFINIDVSTGSHAE-QPWIRAND-----TNNEENEKAKEAYRALKTISLRRSDLDEYKNFE 372

  Fly   315 KQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLRE--ETRVLTDDVI 377
            .:|::.:.:......|.....|.|  .|||.:    ||:|.|||.|:::.::.  :.|
 Worm   373 LRVKERADQKYNYTNITGKDYEMN--NFISAF----YDAVLLYAIALNETIQSGLDPR------- 424

  Fly   378 FEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPV 442
                 ||.. |.:.:..||::.|||: :.||..||...::|:|...          |.....|.|
 Worm   425 -----NGHN-ITSRMWGRTFVGITGN-VSIDHNGDRYSDYSLLDLD----------PVQNRFVEV 472

  Fly   443 AYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHY-----TSTVAAVVLGVL 502
            ||:.....  :.|.: |.:.| .||:.|.|.|:||:....|.....|.     :..:..|::|:.
 Worm   473 AYYSGASN--QLKTV-GQLHW-VGGKPPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLF 533

  Fly   503 LFCSGVITMSIYRKWKIELEIEGLLWKI------------------------------------- 530
            :|        .:|::|:|.|:..:.|||
 Worm   534 IF--------FWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLR 590

  Fly   531 ---------------------------------------------------------------DP 532
                                                                           .|
 Worm   591 STSRSSVNSDKFDEDSLIPIRFRLRSSSSGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGLTP 655

  Fly   533 NEI-KGYSG-----NEI----------VSSPS--------------------KVSLMSAQ-SYG- 559
            |.: |..:|     ||:          |||||                    .:||.:.: |:|
 Worm   656 NSLQKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGM 720

  Fly   560 --------------SRWTNQFVTSTGRLRGAVVRIKEL-----KFPRKRDISREIMKEMRLLREL 605
                          ::...|..|.|...:|.||.||:|     |:|| .|:||..:.|::.:::|
 Worm   721 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPR-LDLSRAQLMELKKMKDL 784

  Fly   606 RHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQL 670
            :||:|..|.||.::.....:||:||.||||.||:|||.|:||.|...||:|||:||:.::|||::
 Worm   785 QHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEI 849

  Fly   671 VYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAEN---ESIGEHQHYRNQLWRAPELLRNH---I 729
            ..||.||||||||.||::|:|||||||.| .|.|.   |.||||.:|:..||.||||||:.   .
 Worm   850 RSHGRLKSSNCVVDSRFVLKVTDFGLHRL-HCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPP 913

  Fly   730 HGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRPEVESIIEAE-- 790
            .|:||||:|:||||::|:..|||.|...|  ..|.|||..|:|...:.::|.||.|....|.|
 Worm   914 MGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGD 978

  Fly   791 -SCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKM-RGGKTKNIMDQMMEMMEKYANNLEDIVTE 853
             :..|.:|:.:..||:|||.||||.|.:|..::.: |..:|.|::|.:::.||:||||||.:|.|
 Worm   979 DALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEE 1043

  Fly   854 RTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVV 918
            ||:....||.|.|:|||::||.::|:.|..|:.|:..|||.||||||||||||::|::|||:|||
 Worm  1044 RTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVV 1108

  Fly   919 NFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAH 983
            ..|||||..||.::..:.||||||||||||||||||.:..| ||.:||.|:|.|||.||...|.|
 Worm  1109 TLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRH 1172

  Fly   984 RPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKL- 1047
            ||:|.||||||||:|.|||||||..|||||||||||||:|||||||..||||:|.:   ..|.|
 Worm  1173 RPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQ---TYDILM 1234

  Fly  1048 -GGGYITEKRGLVNMKGKGDVVTWWLTG 1074
             ..|:..|.||.|.|||||...|:||.|
 Worm  1235 QEAGFKLELRGSVEMKGKGMQTTYWLRG 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	92/499 (18%)
		PK_GC-A_B	543..827	CDD:270944	138/346 (40%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	121/193 (63%)
gcy-28	NP_001021600.1	Periplasmic_Binding_Protein_type1	43..485	CDD:471960	96/529 (18%)
		PK_GC-A_B	722..1016	CDD:270944	128/295 (43%)
		HNOBA	<1023..1071	CDD:462234	23/47 (49%)
		CYCc	1050..1233	CDD:214485	119/186 (64%)