DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	1183	Identity:	343/1183 - (28%)
Similarity:	531/1183 - (44%)	Gaps:	260/1183 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ALTMALDEVNK-----DPNLLPN---VYLD---LRWNDTKGDTVLATKAITEMICD---GIATIF 99
            |:...||.|.|     |.|:..|   :|.|   .:..|.:..|......:.|:..|   |.| :.
Mouse    57 AVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCA-LM 120

  Fly   100 GPEGPC---YVEAIVSQSRNIPMIS-----YKCAEYRASAIPTFARTEPPDTQVVKSLL------ 150
            ||.  |   ..:..:....|.||||     ..| :|:    .|..|..||..:::..|:
Mouse   121 GPS--CTYSTFQMYLDTELNYPMISAGSYGLSC-DYK----ETLTRILPPARKLMYFLVDFWKVN 178

  Fly   151 -ALLRYYAWNKFSILYEDVWSP-----VADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCR 209
             |..:.::||. |.:|::...|     ..:.|:...:..:..:|.|               |..|
Mouse   179 NASFKPFSWNS-SYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFK---------------DVLR 227

  Fly   210 SGYWYQLVQNTMNR-TRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYL 273
            ....:|.:....|| :.:.|..|...|..|....::.|     .:.:||.||:
Mouse   228 RSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVA-----EDTVVILVDL------------ 275

  Fly   274 RRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESN 338
                    .||.:..||.........|:..|.|::.....|...:::||.            .|:
Mouse   276 --------FSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSG------------RSD 320

  Fly   339 FSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRV----IDTIIKNRTYMS 399
            ||      .|||                 |..:|...::.....||..|    .....:|.|:..
Mouse   321 FS------LAYL-----------------EGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQG 362

  Fly   400 ITGSKIKIDQYGDSEGNFSVL-------------AYKPHKWNNSNNMPCNYHMVPVAYFHQGEEH 451
            ..| .:.:|..||.:...|:|             .|..|| |.:         :|||      |:
Mouse   363 FAG-PVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHK-NKT---------IPVA------EN 410

  Fly   452 PEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRK 516
            |.:...|..:        |.|.|  |...::.         .:|...|..:|....:|.:.:.||
Mouse   411 PNFIWKNHKL--------PNDVP--GLGPQIL---------MIAVFTLTGILVVLLLIALLVLRK 456

  Fly   517 WKIELEIEGLLWKIDPNE-IKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRI 580
            ::.:..:....|...|:| |.....||    .:.:||.              ....|.|..:.|:
Mouse   457 YRRDHALRQKKWSHIPSENIFPLETNE----TNHISLK--------------IDDDRRRDTIQRV 503

  Fly   581 KELKFPRKRDISREI---------MKEMRLLRELRHD--NINSFIGASVEPTRILLVTDYCAKGS 634
            ::.|:.:|:.|.:::         .:::.|.:.|:.|  |:..|.|.....|||..|.:||.:||
Mouse   504 RQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGS 568

  Fly   635 LYDIIENEDIK------LDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTD 693
            |.::: |:.|.      :|..|..|:::|:.|||.|:|:|::..||.|||:||||.||.::::||
Mouse   569 LREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITD 632

  Fly   694 FGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQIN 758
            ||.:.:..            .:..||.|||.||.... |||||||:||||..||..||..|..::
Mouse   633 FGCNSILP------------PKKDLWTAPEHLRQATI-SQKGDVYSFAIIAQEIILRKETFYTLS 684

  Fly   759 FEPKEIVDYVKKLPLKGED----PFRPE--VESIIEAESCPDYVLACIRDCWAEDPEERPEFSVI 817
            ..     |:.:|: .:.|:    ||||:  :|:..|.| ...|:|  ::.||.||||:||:|..|
Mouse   685 CR-----DHNEKI-FRVENSYGKPFRPDLFLETADEKE-LEVYLL--VKSCWEEDPEKRPDFKKI 740

  Fly   818 RNRLKKMRG----GKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVA 878
            .:.|.|:.|    .|.::.||.::..::.|:.|||.:|.|||:|...|:.:.:.|...:||:.|.
Mouse   741 ESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVV 805

  Fly   879 EKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETI 943
            :.|.....|||..|:.||||||||||||.:...|||::||:.|||:|..||:|:..:||||||||
Mouse   806 KSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETI 870

  Fly   944 GDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLT 1008
            ||||:|.||||::||:|||.:|:.|||::|..:....:.|.|...:.:|||:|:||..|||||:.
Mouse   871 GDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIK 935

  Fly  1009 MPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLT 1073
            |||||||||||||||||||.|..|:||:|:.....|.:....::.|.||...:||:|...|:|||
Mouse   936 MPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLT 1000

  Fly  1074 GANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVP-------- 1130
            |..:....      :..||.:.::.|...:.: |....::|.....|..|||.:.|.
Mouse  1001 GMKDQEYN------LPSPPTVENQQRLQTEFS-DMIVSALQKRQASGKKSRRPTRVASYKKGFLE 1058

  Fly  1131 ----RAMDGESTY 1139
                ...|.:|||
Mouse  1059 YMQLNNSDHDSTY 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	90/447 (20%)
		ANF_receptor	48..412	CDD:279440	79/401 (20%)
		PK_GC-A_B	543..827	CDD:270944	98/310 (32%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	99/191 (52%)
		Guanylate_cyc	887..1074	CDD:278633	102/186 (55%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	92/458 (20%)
		PKc_like	480..749	CDD:304357	99/309 (32%)
		STYKc	502..744	CDD:214568	91/264 (34%)
		CYCc	787..978	CDD:214485	99/190 (52%)
		Guanylate_cyc	814..1001	CDD:278633	102/186 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810