DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and gc2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	1208	Identity:	386/1208 - (31%)
Similarity:	578/1208 - (47%)	Gaps:	202/1208 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKDPNLLP 65
            |...:|.||.      :.:...:.||.:...:.|   .|.:.|:    |..:|:..:||||.|..
Zfish    42 WSTIILCLLP------ATNAATIKVGVVGPWSCDPIFTKAQPGV----AARLAVAHINKDPYLSQ 96

  Fly    66 NVYLDLRWNDTKGDTVLATKAITEMICDGIAT----IFGPEGPCYVEA--IVSQSRNIPMISYKC 124
            .:..|....|...:|   :|:....:  |..|    ..||..|.|.||  ::.:|.|..:.|:.|
Zfish    97 GITFDYIILDEDCET---SKSFARFL--GYYTRASGFIGPVNPGYCEAASLLGKSWNKAVFSWSC 156

  Fly   125 AEYRASAI---PTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVWSPVADLLKDQATKRN 184
            .|:....:   ||||||.|..:.|   ||:.:|::.|....|:  .||||...|..|.:......
Zfish   157 IEHELDDVRSHPTFARTMPVPSLV---LLSFMRHFRWAHVGIISSSEDVWVEAAIKLANALRSHG 218

  Fly   185 MTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLF 249
            :.:....|..::... ..|.|...|.....:||...|:...|.   |....|:     :|||...
Zfish   219 LPVGIVTSARNDHTS-VRQTLAKVRKVADLRLVILVMHSVLIG---GRTQKLL-----LETAHDM 274

  Fly   250 ARGEYMVIFV--DMMVYS----------EREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVA 302
            ...:..::|:  |.:.||          .|...|.||..|.:                  |.:..
Zfish   275 RMTDGSLVFMSYDTLFYSLPYHHVTQPALRYNSKLLRAYDAV------------------LTITI 321

  Fly   303 STPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLRE 367
            .:|..:.:.|..::.|:       :.|:|:.......|.....    :|.|:...|.|| :.:|.
Zfish   322 ESPKEQSFYQAFEKAQE-------DGELPKHLKPQQVSPLFGT----IYSSIVFMAHAV-QSVRA 374

  Fly   368 ETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYG--DSEGNFSVLAYKPHKWNNS 430
            ..:.::...|.:.|.|      .:.|..:.:....|...:..|.  |::| ||        |
Zfish   375 AGQWMSGGNIAQNARN------LLFKGGSSLQANSSDFGMLDYVILDTDG-FS--------W--- 421

  Fly   431 NNMPCNYHMVPVAYFHQGEEHPEYKL---------INGSIDWPSGGEKPADEPMCGFANELCKKD 486
                              |..|.|::         :...|.:|..| .|..:..|.|.:.:..:.
Zfish   422 ------------------ELQPTYRIEMQTDMVRFLGRHIHFPYAG-PPRTDSSCWFTHGIICRG 467

  Fly   487 DTHYTSTVAAVVLGVL-LFCSGVITMSIYRKW----------KIELEIEGLLW--------KIDP 532
            ..:....::..:||.| :|.|...:..|.||.          ||.|.:..:.:        |:..
Zfish   468 GVNLFHMISMFLLGFLFIFLSIGCSYCIRRKINKIRLVRGPNKILLTLNDVTFINPSLSNKKLSV 532

  Fly   533 NEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMK 597
            ::.|.......:|..|.||.||:|| .:.:.|   ::.....|....:|.|.:...|.|:.....
Zfish   533 DDSKASDTRMSISERSLVSPMSSQS-PATYEN---SNVAIYEGDWAWMKRLPYGTFRSITPNTSD 593

  Fly   598 EMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGM 662
            ...|:::|||:|||.|:|...:.....:||::|::|||.|::.|:|:|||.:|.:|||.||||||
Zfish   594 VFELMKDLRHENINPFLGFFHDCGVFAIVTEFCSRGSLEDLLVNDDVKLDWMFKSSLILDLIKGM 658

  Fly   663 IYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHY-------RNQLWR 720
            .|:|:.. |.||.|||.||||..|::|::||:|.:|         :.|.|.:       .:.||.
Zfish   659 KYLHHRN-VCHGRLKSRNCVVDGRFVLKITDYGYNE---------VLESQRFPYIEPPAEDLLWT 713

  Fly   721 APELLRNH---IHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPE 782
            |||:||..   :||:..||||:|:|||.|:..|..||..:.....|||..|:|.|        |.
Zfish   714 APEILRGSYPGLHGTHSGDVYSFSIIMQEVVMRGPPFCMLENTFDEIVQKVRKPP--------PM 770

  Fly   783 VESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNL 847
            ...|:..:..|...:..::.||.|.||:||.|..|.::.|.:..||..||:|.|:.|:|:|::||
Zfish   771 CRPIVSPDHAPMECIQLMKQCWNEQPEKRPTFDEIFDQFKNVNKGKKTNIIDSMLRMLEQYSSNL 835

  Fly   848 EDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAES 912
            |:::.|||..|..||.|||.||.:|||.||||.|.:|..|||..::.|::|||||||||.:||.|
Zfish   836 EELIRERTEELEIEKQKTEKLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANS 900

  Fly   913 TPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVK 977
            .|::||:.||||||.||.:|..:||||||||||||||.||:|:.||:|||.|||:|||::|.||.
Zfish   901 EPIEVVDLLNDLYTTFDAVIGNHDVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVG 965

  Fly   978 QHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKL 1042
            ..|:.|.|:..:::|||:||||.|||||||||||||||||||.|||||||.|...:||:.:....
Zfish   966 TFRMRHMPDVPVRIRIGLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIHVHSSTVK 1030

  Fly  1043 ALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPD 1107
            .|.:|..||..|.|....:|||....|:||||  .:...|.|    .:||.|     ||...:.|
Zfish  1031 ILMELKLGYRVELRARTELKGKRIEETYWLTG--RDGFTKPL----PVPPVL-----KSGLESKD 1084

  Fly  1108 SRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSV 1145
            .:....:|:       |:.|||.:.  .:.|.|.:|:|
Zfish  1085 FKVMLKKAV-------RKISTVRQV--AQLTLSDEGNV 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	94/446 (21%)
		ANF_receptor	48..412	CDD:279440	84/388 (22%)
		PK_GC-A_B	543..827	CDD:270944	105/293 (36%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	117/191 (61%)
		Guanylate_cyc	887..1074	CDD:278633	110/186 (59%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	97/467 (21%)
		PK_GC-2D	551..815	CDD:270945	102/285 (36%)
		HNOBA	<824..869	CDD:311573	25/44 (57%)
		CYCc	848..1040	CDD:214485	117/191 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810