Protein Alignment Gyc76C and gucy2f

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_571939.2
• Gene: gucy2f / 140424
• ZFINID: ZDB-GENE-011128-7
• Length: 1107
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 365/1117 - (32%)
• Similarity: 559/1117 - (50%)
• Gaps: 185/1117 - (16%)

  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIF-GPEGP--CYVEA 109
            |..:|:..:|.|.:|.....:|........:|   :||:|..: .:.:|..| ||..|  |...|
Zfish    80 ASRLAVGRINNDFSLDLGCTMDFVILQEACET---SKALTSFVQYENVADAFVGPTNPGYCNAAA 141

  Fly   110 IVSQSRNIPMISYKCAEY---RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVW 169
            ::|::.:..:.|:.|..:   |....||||||.|...:|   |..:|:::.|....|:  .||:|
Zfish   142 LMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRV---LFNVLKFFRWANIGIVSSNEDIW 203

  Fly   170 SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM----NRTRIYVFL 230
            ...|..|......|.:.:....|..:|..                 :::||:    |...|.|.:
Zfish   204 IDTAAKLASALRNRGLPVGIVTSMGNNDT-----------------MLENTLMSIKNAGDIKVII 251

  Fly   231 GAANSLV-------DFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHST 288
            ...:|::       .|::.....|| |.|.|:.|..|.::||    ..|:    .||:    :..
Zfish   252 MCMHSVLIGGEQQATFLTKAYDMGL-ASGRYVFIPYDTLLYS----LPYI----NITY----YPL 303

  Fly   289 ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNL--EIPRLFVESNFSKFISIYAAYLY 351
            :|.::::::...|.:.....|.:.|.:         .||.  ::..|.|.....:...::.. :|
Zfish   304 QNNSKLSKAYDAVLTITLDSDIMTFNE---------AFNAAKQLGELMVTQEPEQVSPLFGT-IY 358

  Fly   352 DSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSE 414
            :|:.|.|.::.. .|...|.|          :||. :....:|.|:   ||  ..|:.|:.|:.:
Zfish   359 NSLYLLAKSMHN-ARRAGRWL----------SGTN-LAYFTRNITF---TGFNQDIQTDEQGNGQ 408

  Fly   415 GNFSVLAYKPHKWNNS------NNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADE 473
            .|:.:|  ....|...      .:|..:..:....:.|...|.|                 |..:
Zfish   409 TNYVIL--DTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPGESP-----------------PPSD 454

  Fly   474 PMCGFA-NELCKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIE------------LEIE 524
            ..|.|. |.:|... |..|......:||.::|   |.|.:|::.:.:|:            |.:|
Zfish   455 SRCWFEDNAICTGGVDIIYVIIAFVIVLIIVL---GSIGLSLFIRRRIQQIQLIKGPNRILLTLE 516

  Fly   525 GLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYG--SRWTNQFVTSTGR------LRGAVVRIK 581
            .|.: |:|...|.....|.:|. || |.:..:|.|  ||..|...|:|..      ..|..|.:|
Zfish   517 DLTF-INPQLSKRKITLEDLSD-SK-SYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLK 578

  Fly   582 ELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKL 646
            :......:::.:...|....:::||::|:|.|:|...:.....:||::|::|||:|::.|:|:||
Zfish   579 KFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKL 643

  Fly   647 DDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHEL--RQCAENESIG 709
            |.:|.:||:.||||||.|:|:.:.. ||.|||.||||..|::|::||:|.:|:  .|.|..|::.
Zfish   644 DWMFKSSLVLDLIKGMKYLHHREFP-HGRLKSRNCVVDGRFVLKITDYGYNEILETQKAPKETLP 707

  Fly   710 EHQHYRNQLWRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKL 771
            ....:    |.|||.||   :...|:.|||||:||||:.|:..|..|:..:...|:||:..|||.
Zfish   708 PEDLF----WTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKP 768

  Fly   772 PLKGEDPF-RPEVESIIEAESCPDYV-LACI---RDCWAEDPEERPEFSVIRNRLKKMRGGKTKN 831
            |     |. ||.|        .||.. |.||   :.||:|.|:.||.|..|.::.|.:..||..|
Zfish   769 P-----PMCRPTV--------APDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTN 820

  Fly   832 IMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVT 896
            |:|.|:.|:|:|::||||::.|||..|..||.:||.||..|||.||||.|..|..|||..:|.||
Zfish   821 IIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVT 885

  Fly   897 IYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRH 961
            ||||||||||.:|:.|.|::||:.|||||::||.::..:||||||||||||||.||||.|||::|
Zfish   886 IYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKH 950

  Fly   962 AGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRME 1026
            |.|||:|:|.:|.:|...::.|.|...:::|||:|:||.||||||||||||||||||||||||||
Zfish   951 AAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRME 1015

  Fly  1027 SNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG-ANENAIQKKLVDMMDM 1090
            |.|...:||::......|..|..||..:.||...:||||...|:||.| ||
Zfish  1016 STGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKAN-------------- 1066

  Fly  1091 PPPLFSRPRKSP 1102
                |::|..:|
Zfish  1067 ----FTKPLPNP 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	88/425 (21%)
		PK_GC-A_B	543..827	CDD:270944	106/301 (35%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	114/191 (60%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF-like	59..440	CDD:380594	88/422 (21%)
		PK_GC-2D	551..816	CDD:270945	100/282 (35%)
		HNOBA	<825..870	CDD:462234	25/44 (57%)
		CYCc	850..1042	CDD:214485	115/191 (60%)