Protein Alignment Gyc76C and LOC1280523

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_061513356.1
• Gene: LOC1280523 / 1280523
• VectorBaseID: AGAMI1_003698
• Length: 1620
• Species: Anopheles gambiae
• Alignment Length: 1598
• Identity: 908/1598 - (56%)
• Similarity: 1081/1598 - (67%)
• Gaps: 189/1598 - (11%)

  Fly    21 NHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATK 85
            |:|||||:|||||:.|||..:|||.|||||||||||:|.||.|||||.|.||||||:|:||:||:
Mosquito   119 NNRTVLTLGYLTAVKGDLIEKQGLTISGALTMALDEINNDPELLPNVTLALRWNDTRGETVVATR 183

  Fly    86 AITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAE-YRASAIPTFARTEPPDTQVVKSL 149
            .||||||||:|..|||||.|..||||||||:||||||:|:| .|:|.||||||||||||||.||:
Mosquito   184 VITEMICDGVAAFFGPEGTCQTEAIVSQSRDIPMISYRCSELQRSSPIPTFARTEPPDTQVTKSI 248

  Fly   150 LALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWY 214
            ::||.||.|.||||::|.:|..||..|:.||...|:::||.:...|| .|||:..:|||||||||
Mosquito   249 ISLLTYYGWRKFSIIHEQLWKNVATSLETQAKNNNLSVNHVEMVFDN-YKCCQDDMDCCRSGYWY 312

  Fly   215 QLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQI 279
            .::|.||||||||||||.:|.|||.|::|:...|||:|||:||..|||.||.:.:.|||.||::.
Mosquito   313 TVIQKTMNRTRIYVFLGNSNQLVDMMATMDGMQLFAKGEYLVISADMMTYSPKLSNKYLWRVEKP 377

  Fly   280 TFMSNCHSTE-NFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFI 343
            ..:.||.... :|.:.::|||||.::.|...:..||.:|::|:.|.||..:.|.||  ..|.|::
Mosquito   378 PNVKNCMDLPGDFERRSKSLLVVVASEPLPTFEAFTHKVREYTQKEPFFFKQPSLF--HQFVKYV 440

  Fly   344 SIYAAYLYDSVKLYAWAVDKMLREET--RVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIK 406
            |||||||||||||||||:||:|:||.  |.||.|||.:||||||::|.|||.||||.|:.|:.||
Mosquito   441 SIYAAYLYDSVKLYAWALDKLLKEEQQHRPLTSDVIRDVASNGTKIIQTIINNRTYHSVAGATIK 505

  Fly   407 IDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYF-------------HQGEEHPEYKL-- 456
            ||.||||||||||||.| .::....|..|.:.|.|||:|             |:.:|.||:||
Mosquito   506 IDDYGDSEGNFSVLALK-REFYEEANFSCEFQMRPVAHFQMRQPQHLNDTNQHRNDEIPEFKLSK 569

  Fly   457 INGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIEL 521
            :..:|||| |.::|.|||.|||.||.|.|||||..|.|.|.||.::|||:|||||||||||||||
Mosquito   570 VGNAIDWP-GSDRPMDEPSCGFMNEHCMKDDTHIMSMVVAGVLALILFCAGVITMSIYRKWKIEL 633

  Fly   522 EIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFP 586
            |||||||||||.:||||...||||||||:||.||||:|||.:||..|.|.|.|..|||||||||.
Mosquito   634 EIEGLLWKIDPGDIKGYFNTEIVSSPSKLSLASAQSFGSRCSNQVFTPTARFRSVVVRIKELKFS 698

  Fly   587 RKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFI 651
            |::||||||||||||||:||||||||||||.|||.||||||||||||||||||||||||||||||
Mosquito   699 RRKDISREIMKEMRLLRDLRHDNINSFIGACVEPMRILLVTDYCAKGSLYDIIENEDIKLDDLFI 763

  Fly   652 ASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRN 716
            |||:|||||.|||||:|.|.||||||||||||||||||||||||||:||.|||||||||||||||
Mosquito   764 ASLVHDLIKAMIYIHSSALNYHGNLKSSNCVVTSRWMLQVTDFGLHDLRHCAENESIGEHQHYRN 828

  Fly   717 QLWRAPELLRN-HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFR 780
            ..|::|||||. .::|:|||||||||||::||..|:||||....|||||:|.||.||..|:||||
Mosquito   829 LFWKSPELLRQPSVYGTQKGDVYAFAIILFEIIGRRGPFGYTELEPKEIIDRVKALPEPGKDPFR 893

  Fly   781 PEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYAN 845
            |::||:||.|:..|||:.||||||.|:.:.||:|..||||||:|||||:||||||||||||||||
Mosquito   894 PDIESVIENENVSDYVINCIRDCWDENADLRPDFPNIRNRLKRMRGGKSKNIMDQMMEMMEKYAN 958

  Fly   846 NLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSA 910
            |||:||.:|||||||||.||||||||||||.||||||.|.||||||||.||||||||||||||||
Mosquito   959 NLEEIVQDRTRLLCEEKRKTEDLLHRMLPQPVAEKLTKGLGVEPVSYDSVTIYFSDIVGFTAMSA 1023

  Fly   911 ESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHA 975
            ||||||||||||||||||||||:||||||||||||||||||||||.||:||.|||||||||||.|
Mosquito  1024 ESTPLQVVNFLNDLYTVFDRIIKGYDVYKVETIGDAYMVVSGLPITNGNRHVGEIASMALELLQA 1088

  Fly   976 VKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKC 1040
            |:.||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||.:|
Mosquito  1089 VRSHRIAHRPNETLKLRIGIHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISQQC 1153

  Fly  1041 KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLN 1105
            |.|||.| |||:..:|||:.|||||:|:|:||..|.|.||||..||:.|:|||||.|||:|||:.
Mosquito  1154 KDALDTL-GGYVIVERGLIAMKGKGEVMTYWLEAATEQAIQKIPVDVRDLPPPLFCRPRRSPKMT 1217

  Fly  1106 PDSRQPSIQAMHFCG------------TGSRRQSTVPR---AMDGESTYSLQGSVRESPRMVSKR 1155
            .|||.|||..:...|            .||||||...|   ..|.||:||||||: ..| ||...
Mosquito  1218 YDSRHPSIIGLPGGGMITTVSGMGSYMPGSRRQSCAHRVGGGADHESSYSLQGSM-FGP-MVPMM 1280

  Fly  1156 DRDRERPPINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGG-----VSGSGSGLV 1215
            ..|...||.:.|.|.:         .:.|::.::..|...:.|.:|....|     |:..||.:.
Mosquito  1281 RADSSPPPRHRLDAVY---------REGSIALMDDGEDGYSQCTLDQRPMGPTAPTVTTLGSKIA 1336

  Fly  1216 RQPNALHKPLAMVRPHR--------IISAAQLPQL-------GDNDDDSADTLLRESRSLDPMP- 1264
            ...|..........|.|        |.||....||       |....::|  ||||||||||.|
Mosquito  1337 SSDNLKRALFGTNSPGRRLSHKLRSITSADDYKQLCSSMAANGGRSPEAA--LLRESRSLDPFPV 1399

  Fly  1265 -MQQLRKRHDRV--KLP--------PSKLSKNNSRSLDTGVSLISGNPNGEVHSSQLDLDNEMTA 1318
             ::..|||.|.:  ::|        ||:....:..|:...||.||       |.|
Mosquito  1400 TLEPRRKRLDALAKRVPRLAKTIAAPSRTGSQSFVSVPPAVSTIS-------HES---------- 1447

  Fly  1319 NPVDATDGYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVPTGRSAGGGGGGREGGGSNCAKH- 1382
             ..|:|...:|:..|           .|.|||                |.|..:........:|
Mosquito  1448 -IADSTVRLEDDQHL-----------QRLSGS----------------GHGNAKPPNSHGETQHH 1484

  Fly  1383 -----------LNNNCNGGVN---VEDDLESPLLQRQASLSVPPEE------MLAHN---KRWHS 1424
                       .||||||.:.   .|:....|||.||.||:.|.|.      :..:|   |||:|
Mosquito  1485 HHHHHHHHKYLHNNNCNGSIGNGAAEEQATCPLLTRQTSLTTPQEHEHHCPGLYTNNSSSKRWYS 1549

  Fly  1425 LEHMDGPGGHGGNSVSYAADIDNRHPGDLDFFSGSSNQHHRSKAAGGSKLTNWMTNIFKGNGVRS 1489
            |||:..|                    |.|..|        .|:...|.|.:|:.....|||.:|
Mosquito  1550 LEHVGVP--------------------DEDSCS--------KKSLTRSSLKSWLVGFIHGNGFKS 1586

  Fly  1490 GEA--RRVGILPSGVHGARTGFTDMAASAAARDRESIV 1525
            .::  |:||:||.||.|. |||.::..:.   ::||:|
Mosquito  1587 SDSSLRKVGVLPVGVGGV-TGFGELQPTP---EKESMV 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	251/422 (59%)
		PK_GC-A_B	543..827	CDD:270944	216/284 (76%)
		HNOBA	<833..881	CDD:462234	42/47 (89%)
		CYCc	860..1052	CDD:214485	173/191 (91%)
LOC1280523	XP_061513356.1	None