Protein Alignment Gyc76C and Npr2

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_446290.1
• Gene: Npr2 / 116564
• RGDID: 620851
• Length: 1047
• Species: Rattus norvegicus
• Alignment Length: 1101
• Identity: 401/1101 - (36%)
• Similarity: 592/1101 - (53%)
• Gaps: 151/1101 - (13%)

  Fly    46 ISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLA-----TKAITEMICDGIATIFGPEGPC 105
            :..|:.:|::.:.:   .||   :|||:..::.|...:     .:|:...:......:.|| |..
  Rat    45 VGPAVALAVEALGR---ALP---VDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGP-GCV 102

  Fly   106 YVEAIVSQSR---NIPMI---------SYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAW 158
            |..|.|::..   ::|::         :.|...||     |..||.|...::.:.::.|..::.|
  Rat   103 YPAASVARFASHWHLPLLTAGAVASGFAAKNEHYR-----TLVRTGPSAPKLGEFVVTLHGHFNW 162

  Fly   159 N-KFSILYEDVWSP----------VADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGY 212
            . :.::||.|..:.          |.:.|:..    |:::.|:   :..|           ..|.
  Rat   163 TARAALLYLDARTDDRPHYFTIEGVFEALQGS----NLSVQHQ---VYTR-----------EPGG 209

  Fly   213 WYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVD 277
            ..|.........||....|....|.:.:...:...| ..|:|:..::|:...|.|...   .|..
  Rat   210 PEQATHFIRANGRIVYICGPLEMLHEILLQAQRENL-TNGDYVFFYLDVFGESLRAGP---TRAT 270

  Fly   278 QITFMSNCHSTENFNQMARS-----LLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEI-PRLFVE 336
            ...:..|  .|:...|..|.     |::....||..:|.:|..:: ...::..|.:|: |.|
  Rat   271 GRPWQDN--RTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRL-LIRAREDFGVELAPSL--- 329

  Fly   337 SNFSKFISIYAAYLYDSVKLYAWAVDKMLRE-ETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSI 400
                  :::.|...||.:.|||..:::.::| .||           .:|.|:::. ::.|.|..:
  Rat   330 ------MNLIAGCFYDGILLYAQVLNETIQEGGTR-----------EDGLRIVEK-MQGRRYHGV 376

  Fly   401 TGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPS 465
            || .:.:|:..|.|.:|.:       |...:....::.  |.|::...|:  :.......|.|..
  Rat   377 TG-LVVMDKNNDRETDFVL-------WAMGDLESGDFQ--PAAHYSGAEK--QIWWTGRPIPWVK 429

  Fly   466 GGEKPADEPMCGF--ANELCKKDDTHYTSTVAAVVL--GVLLFCSGVITMSIYRKWKIELEIEGL 526
            |. .|.|.|.|.|  .:..|.|..   .||:|.|.|  |:.....||.:..|:||..:|.|:..:
  Rat   430 GA-PPLDNPPCAFDLDDPSCDKTP---LSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASM 490

  Fly   527 LWKIDPNEIK-GYSGNEIVSSPSKVSL-MSAQSYGSRWT----NQFVTSTGRLRGAVVRIKELKF 585
            ||:|...|:: |.|......:.|:::| :...||||..|    .|...:||..:|.||.||.:.
  Rat   491 LWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVN- 554

  Fly   586 PRKR-DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDL 649
             :|| :::|:::.|::.:|:::.:::..||||.::|..|.:||:||.:|||.||:||:.|.||.:
  Rat   555 -KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM 618

  Fly   650 FIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHY 714
            |..|||:||:|||.::|||.:..||:||||||||.||::|::||:||...|..||.:.  .|..|
  Rat   619 FRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDD--SHALY 681

  Fly   715 RNQLWRAPELLRNH---IHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLK 774
            ..:||.|||||..:   ..|.||.|||:||||:.||..|.|||  ..::..|||||..|:    .
  Rat   682 AKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVR----N 742

  Fly   775 GEDP-FRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMME 838
            |:.| |||   ||...:...:.||...| |||:||.|||:|..|:..:::.......:|:|.::.
  Rat   743 GQRPYFRP---SIDRTQLNEELVLLMER-CWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLL 803

  Fly   839 MMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIV 903
            .||:||||||.:|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||
  Rat   804 RMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIV 868

  Fly   904 GFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASM 968
            ||||:||||||:|||..||||||.||.||..:|||||||||||||||||||.:||.|||.|||.|
  Rat   869 GFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARM 933

  Fly   969 ALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALK 1033
            ||.||.||...||.|||::.|:||||:|||||.||||||.|||||||||||||||||||||:|||
  Rat   934 ALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALK 998

  Fly  1034 IHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094
            ||:|:..|.|||:| |.:..|.||.|.|||||.:.|:||.|..:.            ||.|
  Rat   999 IHVSSTTKDALDEL-GCFQLELRGDVEMKGKGKMRTYWLLGERKG------------PPGL 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	81/433 (19%)
		PK_GC-A_B	543..827	CDD:270944	123/295 (42%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	137/191 (72%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607	82/445 (18%)
		PK_GC-A_B	518..792	CDD:270944	121/285 (42%)
		HNOBA	<798..846	CDD:462234	26/47 (55%)
		CYCc	825..1009	CDD:214485	132/183 (72%)