DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy2f

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_446283.1	Gene:	Gucy2f / 116556	RGDID:	620439	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1184	Identity:	374/1184 - (31%)
Similarity:	556/1184 - (46%)	Gaps:	206/1184 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPFN-LLLLLSVAVRDCSNH--------RTVLTVGYLTALTGDLKTRQGLAISG----------- 48
            |||: ||...:::.|....|        |.:..:..|..:.........:.:.|
  Rat     6 WPFSRLLSWFAISSRLSGQHGLTSSKFLRYLCLLALLPLIWWGQALPYKIGVIGPWTCDPFFSKA 70

  Fly    49 ----ALTMALDEVNKDPNLLPNV---YLDLRWNDTKGDTVLATKAITEMIC-DGIATIF-GPEGP 104
                |..:|::.:::|.:...:.   |:.|      .:....:||:|..|. ..:|:.| ||..|
  Rat    71 LPEVAAALAIERISRDMSFDRSYSFEYVIL------NEDCQTSKALTSFISHQQMASGFVGPANP 129

  Fly   105 CYVEA--IVSQSRNIPMISYKCAEYRAS---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL 164
            .|.||  ::..|.:..:.|:.|..:...   :.|||:||.|...:|   |:.:::|:.|....::
  Rat   130 GYCEAASLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVI 191

  Fly   165 Y--EDVW----SPVADLLKDQATKRNMTINHKQSFIDNR--VKCCEQMLDCCRSGYWYQLVQNTM 221
            .  ||:|    :.|:..|:.......:.:...|   |:|  .|..:|:              ...
  Rat   192 SSDEDIWVHTANQVSSALRSHGLPVGVVLTSGQ---DSRSIQKALQQI--------------RQA 239

  Fly   222 NRTRIYV---------------FLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEK 271
            :|.||.:               ||..|:.|           ....|.|:.:..|:::||
  Rat   240 DRIRIIIMCMHSALIGGETQTHFLELAHDL-----------KMTDGTYVFVPYDVLLYS------ 287

  Fly   272 YLRRVDQITFMSNCHSTENFNQMARS-----LLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIP 331
                   :.:..:.:.....||..|.     |.:...:.....|..||:...        ..|||
  Rat   288 -------LPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAA--------GGEIP 337

  Fly   332 RLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRT 396
                |...|..:|.....:|:|:...|.|:...|:|               ||.....::.::..
  Rat   338 ----EKLDSHQVSPLFGTIYNSIYFIAQAMSNALKE---------------NGQASAASLTRHSR 383

  Fly   397 YMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING 459
            .|...|  ..|:.|..|:....:.:|.....:|.....             :..:...|.....|
  Rat   384 NMQFYGFNQLIRTDSNGNGISEYVILDTNGKEWELRGT-------------YTVDMETELLRFRG 435

  Fly   460 S-IDWPSGGEKPADEPMCGFA-NELCKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIEL 521
            : |.:| ||...:.:..|.|| .::|:.. |......|...:|..||..:|.......|..||:|
  Rat   436 TPIHFP-GGRPTSADAKCWFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQL 499

  Fly   522 EIEG----LLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKE 582
             |:|    ||...|...|..:.|:: ..|.:.||........|..:.:...|:|.|..|......
  Rat   500 -IKGPNRILLTLEDVTFINPHFGSK-RGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSN 562

  Fly   583 L-----------KFPRK-----RDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCA 631
            :           |||..     :.|.........::::|||:|:|..:|...:.....:|:::|:
  Rat   563 IAIYQGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCS 627

  Fly   632 KGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL 696
            :.||.||:..:|:|||.:|.:||:.||||||.|:|:.:.: ||.|||.||||..|::|:|||:|.
  Rat   628 RRSLEDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFI-HGRLKSRNCVVDGRFVLKVTDYGF 691

  Fly   697 H---ELRQCAENESIGEHQHYRNQLWRAPELLR--NHIH-GSQKGDVYAFAIIMYEIFSRKGPFG 755
            :   |:.:.:|.|...|     ..||.||||||  ..|. ||..||||:|||||.|:..|..||.
  Rat   692 NNILEMLRLSEEEPSEE-----ELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFC 751

  Fly   756 QINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNR 820
            .::...||::|.:|..|        |....::..|..|...|..::.||||..|:||.|..|.|:
  Rat   752 MMDLSAKEVIDRLKMPP--------PVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQ 808

  Fly   821 LKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQ 885
            .|....||..||:|.|:.|:|:|::||||::.|||..|..||.|||.||.:|||.||||.|..|.
  Rat   809 FKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGC 873

  Fly   886 GVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVV 950
            .|||..:||||:|||||||||.:||.|.|::||:.||||||:||.||..:||||||||||||||.
  Rat   874 TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVA 938

  Fly   951 SGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLF 1015
            ||||.:||.|||.|||:|:|::|.:|...::.|.|...:::|||:||||||||||||||||||||
  Rat   939 SGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLF 1003

  Fly  1016 GDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080
            ||||||||||||.|...:||:|......|..|..||..|.||...:||||...|:||.|
  Rat  1004 GDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVG------ 1062

  Fly  1081 QKKLVDMMDMPPPL 1094
            :|.....:.:|||:
  Rat  1063 KKGFTKPLPVPPPV 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	82/473 (17%)
		ANF_receptor	48..412	CDD:279440	78/418 (19%)
		PK_GC-A_B	543..827	CDD:270944	102/305 (33%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	122/191 (64%)
		Guanylate_cyc	887..1074	CDD:278633	117/186 (63%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	82/470 (17%)
		ANF_receptor	75..412	CDD:279440	79/413 (19%)
		PKc_like	545..815	CDD:304357	98/283 (35%)
		TyrKc	565..809	CDD:197581	93/257 (36%)
		HNOBA	<824..869	CDD:285003	26/44 (59%)
		CYCc	848..1040	CDD:214485	122/191 (64%)
		Guanylate_cyc	875..1062	CDD:278633	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810