DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and ADCY9

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	475	Identity:	119/475 - (25%)
Similarity:	194/475 - (40%)	Gaps:	118/475 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   861 EKMKTEDLLHRMLPQSVAEKLTMGQGVE--------------------------PVSY------- 892
            ||...|.::|.::|:.:|:.| |.||.|                          |:::
Human   326 EKALKERMIHSVMPRIIADDL-MKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQ 389

  Fly   893 -DLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIK 956
             :.|:|.|:||||||.|||..:...:|..||||:..|||:.......|:.|:||.|..|:|.|..
Human   390 IEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEP 454

  Fly   957 NGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNT 1021
            ..| ||.....|.|.::.|::|  ......|.:.:|:|:|||.|:.|::|:...::.::.:.||.
Human   455 RAD-HAYCCIEMGLGMIKAIEQ--FCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNL 516

  Fly  1022 ASRMESNGEALKIHISNKCKLALD---KLGGGYITEKRG--LVNMKGKGDVVTWWLTGANENAIQ 1081
            |:.||..|.|.|:|||......||   ::..|.:.|:.|  :|..:.|| :.|:.::|....
Human   517 ANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKG-LKTYLISGQRAK--- 577

  Fly  1082 KKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAM--HFCGTGSRRQSTVPRAMDGESTYSLQGS 1144
                                     :||....:|:  .|......:.|:.||   |:.|.| .|:
Human   578 -------------------------ESRCSCAEALLSGFEVIDGSQVSSGPR---GQGTAS-SGN 613

  Fly  1145 VRESPRMVSKRDRDRERP-------PINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDG 1202
            |.:..:.|...|..:..|       |.:..||   .|||.....|                |...
Human   614 VSDLAQTVKTFDNLKTCPSCGITFAPKSEAGA---EGGAPQNGCQ----------------DEHK 659

  Fly  1203 GSGGVSGSGSGLVRQPNALHKPLAMVRP-----HRIISAAQLPQLGDNDDDSADTLLRESR---- 1258
            .|..|:.|....:..|...|.|.|...|     :.::|..|..:|.::.....:.|..:.|
Human   660 NSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGV 724

  Fly  1259 SLD-----PMPMQQLRKRHD 1273
            |||     |:..:.:|::.|
Human   725 SLDQSALLPLRFKNIREKTD 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003	6/19 (32%)
		CYCc	860..1052	CDD:214485	70/227 (31%)
		Guanylate_cyc	887..1074	CDD:278633	66/225 (29%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113
		CYCc	326..544	CDD:214485	69/221 (31%)
		Guanylate_cyc	385..573	CDD:278633	64/191 (34%)
		CYCc	1043..1243	CDD:214485
		Guanylate_cyc	1069..1260	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810