DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc76C and ADCY8

DIOPT Version :9

Sequence 1:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1275 Identity:270/1275 - (21%)
Similarity:447/1275 - (35%) Gaps:437/1275 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 YEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMN----RTR 225
            |..|..|.   |::....|::...:::.|:..|.|.              ::|.|.::    .|.
Human   149 YRGVIFPT---LRNSFKSRDLERLYQRYFLGQRRKS--------------EVVMNVLDVLTKLTL 196

  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTEN 290
            :.:.|..|::.:|.:..: ..|.|. |..:||...::|..:..:..||:....:|:::..     
Human   197 LVLHLSLASAPMDPLKGI-LLGFFT-GIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMT----- 254

  Fly   291 FNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKP-P-----------------FNLEIPRLFVES 337
             .|:..:.|..........|:.|| ....||..| |                 ..:.||||.|.|
Human   255 -TQILAAGLGYGLLGDGIGYVLFT-LFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVIS 317

  Fly   338 NFSKFIS------------IYAAYLYDSVKLYAW-----AVDKMLREETR----------VLTDD 375
             .::.::            |:.:||.|..:..|:     .|:..||.||.          ||...
Human   318 -INQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRF 381

  Fly   376 VIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMV 440
            |:.|:.::.|.|.|..::::.:      :|.|.:|    .|.|:|......:.|.:.......:|
Human   382 VVLEMINDMTNVEDEHLQHQFH------RIYIHRY----ENVSILFADVKGFTNLSTTLSAQELV 436

  Fly   441 PV-----AYFHQ-GEEHP--EYKLINGSIDWPSGGEKP-ADEPMC------------GFANELCK 484
            .:     |.|.: ..||.  ..|::.......||..:| .|...|            .:.....|
Human   437 RMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTK 501

  Fly   485 KD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSS-- 546
            .| |........:|:.|||    |:      |||:.::    ..|.:|       ..|::.|.  
Human   502 HDVDMRIGIHSGSVLCGVL----GL------RKWQFDV----WSWDVD-------IANKLESGGI 545

  Fly   547 PSKVSLMSA------------QSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDIS--REIMK 597
            |.::.:..|            :.:|.. .|:|      ||...:....:|.|....:|  .:|:|
Human   546 PGRIHISKATLDCLNGDYNVEEGHGKE-RNEF------LRKHNIETYLIKQPEDSLLSLPEDIVK 603

  Fly   598 EM----------------RLLRELRHDNINSFIG-----ASVEPTRILLVTDYCAKGSLY----- 636
            |.                ....||..|||   :|     |::....|.|:.::.|: :|:     
Human   604 ESVSSSDRRNSGATFTEGSWSPELPFDNI---VGKQNTLAALTRNSINLLPNHLAQ-ALHVQSGP 664

  Fly   637 ----------------DIIENEDIKLDDLFI--ASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVV 683
                            |.:..|.||...|..  :||.|.      |......|:..||..:..|:
Human   665 EEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHK------YSQMRDEVFKSNLVCAFIVL 723

  Fly   684 -----------TSRWMLQVTDFG----LHE-----------------LRQ--CAENESIGEHQHY 714
                       :||.|.....|.    ||.                 ||:  |..||:.      
Human   724 LFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETY------ 782

  Fly   715 RNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEI----VDYVKKLPLKG 775
                     |.||         |..||.|:            |||....:    .|:.|.:|||.
Human   783 ---------LARN---------VIIFASIL------------INFLGAILNILWCDFDKSIPLKN 817

  Fly   776 EDPFRPEVESIIEAESC--PDY-----VLACIRDCWAEDPEERPEFSVIRNRLK----------- 822
            . .|.   .|.:..:.|  |:|     |||.: .|        ..|..:.:.||           
Human   818 L-TFN---SSAVFTDICSYPEYFVFTGVLAMV-TC--------AVFLRLNSVLKLAVLLIMIAIY 869

  Fly   823 -----------------------KMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMK 864
                                   ...|.|..:::...|.::..:.:..:...|.|...|...:.|
Human   870 ALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAK 934

  Fly   865 ------------TEDLLHRMLPQSVA----EKLTMGQGVEPVSYDLVTIYFSDIVGF------TA 907
                        .|::|..:||..||    ||....:.:...|||.|.:.|:.|.||      |.
Human   935 EEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999

  Fly   908 MSAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGL-PIKN--GDR--HAGE 964
            |:.:.  ::.:..||::...||.::   |..|:.|::|||..||.|||| |.|.  .|:  |...
Human  1000 MNNQG--VECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCA 1062

  Fly   965 IASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNG 1029
            :|..:|.|..::::  |........:||||:..|.|||||:|...|:|.::|.|||.||||:|.|
Human  1063 LADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTG 1125

  Fly  1030 EALKIHISNKCKLAL-DKLGGGYITEKRGLVNMKG----KGDVVTWWLTGANENAIQKKLVDMMD 1089
            .:.:|.:..:..|.| |:   |:..:.||.:.:||    :|.:.|::|.|               
Human  1126 VSGRIQVPEETYLILKDQ---GFAFDYRGEIYVKGISEQEGKIKTYFLLG--------------- 1172

  Fly  1090 MPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSK 1154
                   |.:.:|.:.|                       ||.:.|:  |||...|.   .:|..
Human  1173 -------RVQPNPFILP-----------------------PRRLPGQ--YSLAAVVL---GLVQS 1202

  Fly  1155 RDRDRERPPIN-----GLGAGHFVGGALLE------SAQA 1183
            .:|.|::..:|     |:..||:....||.      .|||
Human  1203 LNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQA 1242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365 64/333 (19%)
ANF_receptor 48..412 CDD:279440 58/295 (20%)
PK_GC-A_B 543..827 CDD:270944 76/422 (18%)
HNOBA <835..881 CDD:285003 12/61 (20%)
CYCc 860..1052 CDD:214485 71/222 (32%)
Guanylate_cyc 887..1074 CDD:278633 69/205 (34%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 8/49 (16%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831 51/262 (19%)
CYCc 366..564 CDD:214485 42/228 (18%)
Guanylate_cyc 405..589 CDD:278633 40/215 (19%)
DUF1053 617..711 CDD:283888 20/103 (19%)
CYCc 944..1148 CDD:214485 70/210 (33%)
Guanylate_cyc 973..1172 CDD:278633 69/205 (34%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 45/187 (24%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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