DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	1169	Identity:	360/1169 - (30%)
Similarity:	539/1169 - (46%)	Gaps:	170/1169 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDT--VLATK 85
            |...|:|.|.....|....|.|. |.|..:|:|.||:|.:||....||.:...|..||  .|||.
  Rat    67 RETFTLGVLGPWDCDPIFAQALP-SMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATF 130

  Fly    86 AITEMICDGIATIFGPEGP--CYVEAIVSQSRNIPMISYKCA--EYRASAIPTFARTEPPDTQVV 146
            ....   :.:|...||..|  |...|:::|.....:.|:.|.  |...:.:||.    |....|
  Rat   131 VAHR---NTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTL----PSMADV- 187

  Fly   147 KSLLALLRYYAWNKFSIL--YEDVWSPVADLLKDQATKRNMTINHKQSF---IDNRVKCCEQMLD 206
              ||:::|::.|.:.:|:  ::|:|...|..|........:.|....|.   .....:.|:|:
  Rat   188 --LLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQL-- 248

  Fly   207 CCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEK 271
              .|.:..::|...|:.    ..||.....| .:......|| ..|..:.:..|.::::
  Rat   249 --HSVHGLKIVVLCMHS----ALLGGLEQTV-LLRCARKEGL-TDGRLVFLPYDTLLFA------ 299

  Fly   272 YLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQ--FTKQVQKYSSKPPFNLEIPRLF 334
                   :.:.:            ||.||:....|.::...  .|..:........|.....|..
  Rat   300 -------LPYRN------------RSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGG 345

  Fly   335 VESNFS-KFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNR-TY 397
            ..:|.. :.:|.....:||:|.|.|.|::                ...::||.:....:.|. ..
  Rat   346 TAANLGPEQVSPLFGTIYDAVILLAHALN----------------HSEAHGTGLSGAHLGNHIRA 394

  Fly   398 MSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS 460
            :.:.|  .:|:||..|.....:.:|     ..|...:.....|::.|:       ..:.:.:..:
  Rat   395 LDVAGFSQRIRIDGKGRRLPQYVIL-----DTNGEGSQLVPTHILDVS-------TQQVQPLGTA 447

  Fly   461 IDWPSGGEKPADEPMCGF-ANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIE 524
            :.:| ||..||.:..|.| .|.||.:......|.:...:..||....|.:.      :.|.|.::
  Rat   448 VHFP-GGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLA------YFIRLGLQ 505

  Fly   525 GLLWKIDPNEI----------------------KGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFV 567
            .|.....|:.|                      .|.....:|...|..|::..   .:|....|:
  Rat   506 QLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQG---STRSVPAFL 567

  Fly   568 --TSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYC 630
              |:....:|..|.:|:.:.....|:....:..:|.:||:||:|:.:|:|..|.|....:|.::|
  Rat   568 EHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHC 632

  Fly   631 AKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFG 695
            |:|||.|::.|||::||..|.|||:.|||:|:.|:|:.... ||.|||.||||.:|::|::||.|
  Rat   633 ARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFP-HGRLKSRNCVVDTRFVLKITDHG 696

  Fly   696 LHELRQCAENESIGEHQHYRNQ------LWRAPELLRNHIH------GSQKGDVYAFAIIMYEIF 748
            ..|.        :..|..:|.|      ||.||||||....      .:.||||::..||:.|:.
  Rat   697 YAEF--------LESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVL 753

  Fly   749 SRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPE 813
            :|..|:.......:||:..|...|        |....::..:..|...:..::.||.|.|::||.
  Rat   754 TRDPPYCSWGLSAEEIIRKVASPP--------PLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPS 810

  Fly   814 FSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVA 878
            ...|..:.|.:..||..::.|.|:.|:|||:.:||.:|.|||..|..|:.|||.||.:|||.|||
  Rat   811 LDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVA 875

  Fly   879 EKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETI 943
            ..|.||..|||..:|.||||||||||||.:||.|.|::||.|||||||:||.::..:||||||||
  Rat   876 HALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETI 940

  Fly   944 GDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLT 1008
            ||||||.||||.:||:|||.|||:||||:|......|:.|.|:..:::|.|:|:||.||||||||
  Rat   941 GDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLT 1005

  Fly  1009 MPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLT 1073
            |||||||||||||||||||.|...:||:|.....||..|..||..:.||...:||||...|:|||
  Rat  1006 MPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLT 1070

  Fly  1074 GANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGES 1137
            |        |......:|.||..:|       .|..|..|......|....|||.......|::
  Rat  1071 G--------KTGFCRSLPTPLSIQP-------GDPWQDHINQEIRTGFAKARQSLAEPRSSGDT 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	88/435 (20%)
		ANF_receptor	48..412	CDD:279440	76/380 (20%)
		PK_GC-A_B	543..827	CDD:270944	91/297 (31%)
		HNOBA	<835..881	CDD:285003	24/45 (53%)
		CYCc	860..1052	CDD:214485	120/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	115/186 (62%)
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	88/447 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556		4/26 (15%)
		PK_GC-2D	554..824	CDD:270945	89/289 (31%)
		CYCc	861..1050	CDD:214485	120/188 (64%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		27/40 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810