DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and ADCY5

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens

Alignment Length:	980	Identity:	203/980 - (20%)
Similarity:	358/980 - (36%)	Gaps:	247/980 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 SEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVV----------ASTPPTKDYIQFTK-QVQ 318
            |:|:|.:..|...|    :..||.....|..|.||.|          |.....::.:.|.| .:|
Human   403 SQRQAFQETRECIQ----ARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQ 463

  Fly   319 KYSSKPPFNLEIPRLFVE-SNFSKFISIYAA--YLYDSVKLYAWAVDKMLRE----ETRVLTD-- 374
            |:.     |:.|  ||.: ..|:...|...|  .:....:|:| ..||:..|    ..::|.|
Human   464 KHD-----NVSI--LFADIEGFTSLASQCTAQELVMTLNELFA-RFDKLAAENHCLRIKILGDCY 520

  Fly   375 -----------DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWN 428
                       |........|..:|:.|...|   .:||..:.: :.|...|..........||.
Human   521 YCVSGLPEARADHAHCCVEMGMDMIEAISLVR---EVTGVNVNM-RVGIHSGRVHCGVLGLRKWQ 581

  Fly   429 N---SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHY 490
            .   ||::....||      ..|.:.....:...::::.:|..:.  ||.||.......|:  |.
Human   582 FDVWSNDVTLANHM------EAGGKAGRIHITKATLNYLNGDYEV--EPGCGGERNAYLKE--HS 636

  Fly   491 TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYS---------------G 540
            ..|.      ::|.|:        :|.|.|..:...:.:...|.| |::               |
Human   637 IETF------LILRCT--------QKRKEEKAMIAKMNRQRTNSI-GHNPPHWGAERPFYNHLGG 686

  Fly   541 NEIVSSPSKVSLMSAQSYGSRWT-------NQFV------TSTGRLRGAVVRIKELKFPRKRDIS 592
            |::.....::.....:...::.:       ::|:      .|..|||...||...|.| |:.|:.
Human   687 NQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF-REPDLE 750

  Fly   593 REIMKEMRLLRELRHDNINS-------------FIGASVEPTRILLVTDYCAKGSLYDIIENEDI 644
            ::..|::       .|...:             |:..::.|..|.:::.|.....|..::....:
Human   751 KKYSKQV-------DDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSV 808

  Fly   645 -------------KLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWML----QVT 692
                         .|....:.|.::..:.|:..|....|....|:.:.|    ||.:|    |..
Human   809 IYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCN----SRDLLGCLAQEH 869

  Fly   693 DFGLHELRQC-----AENESIGEHQHYRNQLW---RAPELLRNHIHGSQKGDVYAFAIIMYEIFS 749
            :....::..|     |.|.|:|:.|.:....|   ..||.....:         ..:::...:|.
Human   870 NISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSV---------LLSLLACSVFL 925

  Fly   750 RKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEF 814
            :....|::.......:.||..:.:.|...| ...:.::.|.:...:            .....::
Human   926 QISCIGKLVLMLAIELIYVLIVEVPGVTLF-DNADLLVTANAIDFF------------NNGTSQW 977

  Fly   815 SVIRN-RLKKMRGGK--TKNIMDQMMEMMEK--------------------YANNLEDIVTERTR 856
            |:..| |.::|..|.  ...:.:|..|...|                    :|..:|.  |.|..
Human   978 SLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVES--TARLD 1040

  Fly   857 LL-----CEEKMKTED-------LLHRMLPQSVAEKLTMGQGVEPVSY----DLVTIYFSDIVGF 905
            .|     .|||.:.|:       |||.:||:.||......:......|    :.|.:.|:.|..|
Human  1041 FLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 1105

  Fly   906 T----AMSAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGLP----IKNGD 959
            :    .:.|.:..::.:..||::...||.||   |...:.|::|||..||..|||.    .|.|.
Human  1106 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK 1170

  Fly   960 RHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASR 1024
            .|...:|..|::|:..:|.  |........:::||::.|||||||:|...|:|.::|:|||.|||
Human  1171 THIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR 1233

  Fly  1025 MESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMD 1089
            |:|.|...:|.::......|  ....|..|.||:|.:||||:::|::|.|.
Human  1234 MDSTGVPDRIQVTTDMYQVL--AANTYQLECRGVVKVKGKGEMMTYFLNGG-------------- 1282

  Fly  1090 MPPPL 1094
              |||
Human  1283 --PPL 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	46/213 (22%)
		ANF_receptor	48..412	CDD:279440	38/177 (21%)
		PK_GC-A_B	543..827	CDD:270944	49/335 (15%)
		HNOBA	<835..881	CDD:285003	19/77 (25%)
		CYCc	860..1052	CDD:214485	65/213 (31%)
		Guanylate_cyc	887..1074	CDD:278633	65/201 (32%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	13/58 (22%)
		Guanylate_cyc	460..633	CDD:306677	37/192 (19%)
		DUF1053	668..760	CDD:399378	15/99 (15%)
		Guanylate_cyc	1087..1281	CDD:306677	65/197 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810