DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and ADCY3

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	272	Identity:	77/272 - (28%)
Similarity:	138/272 - (50%)	Gaps:	37/272 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 MEKYANNL---EDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMG-----QGVEPVSYDLVT 896
            :||.|..|   :..|.::...:.|.:...|.|:..|||:.||... :|     :.:...:||.:.
Human   902 VEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHF-LGSKKRDEELYSQTYDEIG 965

  Fly   897 IYFSDIVGF----TAMSAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGL- 953
            :.|:.:..|    |..|..:..::.:.|||::.:.||.::   :...:.|::|||..||..||:
Human   966 VMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVT 1030

  Fly   954 PIKNGD----------------RHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVA 1002
            |..|.:                :|..::|..||.:...:.  .|.::......|||||:.|.|:|
Human  1031 PDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLT--NINNQSFNNFMLRIGMNKGGVLA 1093

  Fly  1003 GVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDV 1067
            ||:|...|.|.::|:|||.||||||.|....|.:..:.::.|.:.|..::  :||.:.:||||::
Human  1094 GVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFV--RRGPIFVKGKGEL 1156

  Fly  1068 VTWWLTGANENA 1079
            :|::|.|.::.|
Human  1157 LTFFLKGRDKLA 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003	13/43 (30%)
		CYCc	860..1052	CDD:214485	62/220 (28%)
		Guanylate_cyc	887..1074	CDD:278633	61/210 (29%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831
		CYCc	273..490	CDD:214485
		Guanylate_cyc	310..516	CDD:278633
		CYCc	925..1143	CDD:214485	62/220 (28%)
		Guanylate_cyc	956..1163	CDD:278633	61/210 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810