Protein Alignment Gyc76C and adcy4

DIOPT Version :9

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1224
• Identity: 241/1224 - (19%)
• Similarity: 425/1224 - (34%)
• Gaps: 403/1224 - (32%)

  Fly    11 LLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVY----LDL 71
            ::.|.:..|     ::|:||:...|           || |..|.|::.....::.::|    |.:
 Frog    97 IIGVVILGC-----LVTLGYVFIFT-----------SG-LVSAWDQIYWTLFVIISLYTMLPLGM 144

  Fly    72 RWNDTKGDTVLATKAIT------------------EMICDGI----ATIFGPEGPC--------- 105
            :|....|.:......|.                  :||.|.:    ..:.|....|
 Frog   145 KWAIFAGLSCFVAHIIVLSVYVSTVRLLPRDDVALQMIADAVILLCGNVIGGYHKCVTESALKDT 209

  Fly   106 YVEAI---------VSQSRN--------IPMISYKCAEYRASAIPTF--ARTEPPDTQVVKSLLA 151
            |.|||         |||.|.        :|  :|...|.:|..|...  .|.:|.:|....:|
 Frog   210 YHEAINFIHSRLKLVSQERQQERLLLSILP--AYIATEMKAEIIERLKEKRPQPENTNNFHNL-- 270

  Fly   152 LLRYYAWNK-FSILYEDV---------WSPVADLLK--------DQATKRNMTINHK-------- 190
               |...:| .||||.|:         .||...:|.        ||..|.|..:..|
 Frog   271 ---YIKRHKDVSILYADIVGFTLLSSECSPKELVLMLNELFGKFDQIAKDNECMRIKILGDCYYC 332

  Fly   191 ----QSFIDNRVKCCEQM-LDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFA 250
                ..|:.|..|.|..| ||.|      |.::.....|.:.:     |..|...|.....|:..
 Frog   333 VSGLPEFLPNHAKNCVLMGLDMC------QAIRKLRKATGVDI-----NMRVGVHSGNVLCGVIG 386

  Fly   251 --RGEYMVIFVDMMVYSEREAEKYLRRVD----QITFMSNCHSTENFNQMARSLLVVASTPPTKD 309
              :.:|.|...|:.:.:..||.....||.    .::.:.|.:..|:.....|.|.:..:.  .|.
 Frog   387 LQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLSHLENEYEVEDATLAQRDLYLKENN--IKT 449

  Fly   310 YIQFTKQVQKYSSK---PPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRV 371
            |:....:.....::   |..:.|:|::......:::             |.:|..:|.....:.
 Frog   450 YLVIDPRANDGEAEDILPSKSAEVPKMRASVRMTRY-------------LESWGAEKPFAHLSH- 500

  Fly   372 LTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGD-----SEGNFSVLAY--KPHKWNN 429
             .|.::.|..|    :..::....:.:|.|.|:.|.....:     ::.||.::..  ...:|..
 Frog   501 -RDSLVPEPHS----ISHSMDLPMSPLSQTWSQEKSRSTRETNESLNDNNFHIMEVLASQRQWKR 560

  Fly   430 SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEP-------------MCGFANE 481
            |.    :::.:.: ||:......||:|              :|.|             .|.|..:
 Frog   561 SK----DFNRITL-YFNDKAAEKEYRL--------------SDLPSFKYYTACCFFIFACNFIVQ 606

  Fly   482 LCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSS 546
            :.    ..:.:....:..|:..|...::..:.:                     .|:....|:..
 Frog   607 IL----VSHKNAAFGISYGISFFFFLLLLFTCF---------------------AGHLARCILKG 646

  Fly   547 PSKVSLMSAQS--YGSR-WTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHD 608
            |..:..:.:.|  ..|| |....:.....|...|:.:..|.|....:..::
 Frog   647 PQLLHWLPSLSIALSSRPWLRVPLGVFTILTVLVMAVFNLFFLPDNNCPQQ-------------- 697

  Fly   609 NINSFIGASVEPTRILLVTDY---CAKGSL---YDIIENEDIKLDDLFIASLIHDLIKGMIYIHN 667
            :.||.:....||..:..:..|   |..|.|   ..::.|.:.||..|.||.:|:::|
 Frog   698 SWNSSLSPDPEPQMLYSLPYYMYCCILGLLACSAFLLMNFEAKLILLSIALVIYNVI-------- 754

  Fly   668 SQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGS 732
             .|..|..|  |:|.|  .|:..                     .|.|..:.:.|:::     ||
 Frog   755 -FLETHSWL--SDCYV--NWLYM---------------------NHSRPGILKEPKVM-----GS 788

  Fly   733 QKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVL 797
            ....::.|.::   ..||:.             :|..:|                      |::
 Frog   789 ISLFIFFFTLL---ALSRQN-------------EYYCRL----------------------DFL- 814

  Fly   798 ACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEK 862
                  |      :.:|.:.|.|::.|                    .||..:
 Frog   815 ------W------KRKFKMERERIETM--------------------ENLNRV------------ 835

  Fly   863 MKTEDLLHRMLPQSVAEKLTMGQG-----VEPVSYDLVTIYFSDIVGF----TAMSAESTPLQVV 918
                 ||..:||..||::. :||.     :...|||.|.:.|:.|..|    |........|:.:
 Frog   836 -----LLENVLPADVAQQF-IGQNRRNEDLYYQSYDCVCVLFASIPDFKEFYTECDENHEGLECL 894

  Fly   919 NFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGLPI-------KNGDR---HAGEIASMAL 970
            ..||::...||.::   :...|.|::|||.|||..:||..       ::|||   |.|.:...|:
 Frog   895 RLLNEIIADFDELLSKPKFSSVEKIKTIGSAYMAATGLNATSGQENPQDGDRNYNHIGIMVEFAI 959

  Fly   971 EL---LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEAL 1032
            .|   |..:.:|..     ...|||:|::.|||||||:|...|:|.::|:|||.||||:|.|...
 Frog   960 ALIGKLDLINKHSF-----NNFKLRVGINHGPVVAGVIGAQKPQYDIWGNTVNVASRMDSTGVLG 1019

  Fly  1033 KIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWL------TGANENAI 1080
            ||.::.:....|:||  ||..|:||::.:||||.:.|:::      :|:..|.:
 Frog  1020 KIQVTEETTKVLEKL--GYKCERRGVIKVKGKGQLCTYFVSTDMARSGSQGNVL 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	95/519 (18%)
		ANF_receptor	48..412	CDD:279440	86/457 (19%)
		PK_GC-A_B	543..827	CDD:270944	49/292 (17%)
		HNOBA	<835..881	CDD:285003	8/45 (18%)
		CYCc	860..1052	CDD:214485	70/216 (32%)
		Guanylate_cyc	887..1074	CDD:278633	71/212 (33%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	33/171 (19%)
		Guanylate_cyc	270..427	CDD:306677	37/172 (22%)
		DUF1053	483..586	CDD:399378	20/140 (14%)
		Guanylate_cyc	859..1057	CDD:306677	71/204 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910