Protein Alignment Gyc76C and gucy1b2

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_017949923.2
• Gene: gucy1b2 / 100496697
• XenbaseID: XB-GENE-989428
• Length: 781
• Species: Xenopus tropicalis
• Alignment Length: 764
• Identity: 201/764 - (26%)
• Similarity: 310/764 - (40%)
• Gaps: 216/764 - (28%)

  Fly   489 HYTST---VAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIV------ 544
            ||.|.   :..:|.|::    |.:.|..:   |.|:.:| ::.:.|..|..|...:.:.
 Frog   150 HYYSDRRGLCHIVPGIM----GAVAMDFF---KTEISME-IISQSDEEERTGKKEHIVFLVTQKP 206

  Fly   545 ----SSPSKVSLMSAQSYGSRWTNQFVTSTGRL-RGAVVRIKELKFPRKRDISREIMKEMRLLRE 604
                ..|:|..|:|.......:.|.:.....|. :.:|..:|:..:...|.|.:  :.:.|:||.
 Frog   207 AFPPKCPTKPPLVSRGIKNKSFENPYNKYRDRKNQVSVCPVKKNHWAMIRGIVQ--LGKGRMLRG 269

  Fly   605 LRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENED---------------------IKLDD 648
            .|          .|.|..:.:..:...||..:.|:.:|:                     |:||.
 Frog   270 FR----------PVYPKDLCVDVETFCKGLPFHIVFDEELRIKQAGVSIQKIVPGLQTTGIRLDQ 324

  Fly   649 LFIASLIHD----LIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVT--DFGLHELR------- 700
            .|  |.:|.    .|..:....|||.|:.          |.|.|:..:  |..:.|||
 Frog   325 YF--STVHPEVTLTISNVRKFINSQFVFR----------TKREMMPESWRDRPMLELRGQMIWME 377

  Fly   701 --QCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKE 763
              :|              .|:....|||.                ::|:..|
 Frog   378 KLEC--------------MLYLCSPLLRT----------------LHELEER------------- 399

  Fly   764 IVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGK 828
                            :..:..|...:...|.:|                  :.:.||.:|   :
 Frog   400 ----------------QMHISDIAPHDVTRDLIL------------------LNQQRLAEM---E 427

  Fly   829 TKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYD 893
            ..|.:::..|.:...:.:||           |||.|||.||:.|||:.||.:|..|:.||...:.
 Frog   428 LSNQLERKKEELRILSKHLE-----------EEKKKTELLLYAMLPKHVANQLKEGKRVEAGEFK 481

  Fly   894 LVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNG 958
            ..||.|||:|.||.:.|:..|:|:|..||.:|..|||:...:|||||||||||||||.|:|:...
 Frog   482 ECTILFSDVVTFTNICAQCEPIQIVFMLNSMYLRFDRLTTVHDVYKVETIGDAYMVVGGVPVPVS 546

  Fly   959 DRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTAS 1023
            . ||..:|:.||.::...||.:.....| .:::|:|:|:|||:|||||..|||||||||||||||
 Frog   547 S-HAERVANFALGMILMAKQVKNPVNGN-PIQIRVGLHSGPVLAGVVGEKMPRYCLFGDTVNTAS 609

  Fly  1024 RMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWL---TGANENAIQKKLV 1085
            ||||:|...|||||......|.  |..:...:||.:::||||.:.|::|   :.|.||.|..:.:
 Frog   610 RMESHGVPNKIHISPTVYRYLK--GKNFEMTERGEIDVKGKGRMRTYFLIRNSSAKENEILGQAI 672

  Fly  1086 DMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPR---AMDGESTYSLQG---- 1143
            ...|      |....|..|..|:.:.::|..   ..|..::..:.:   |:..:...||||
 Frog   673 KETD------SGRASSQSLLDDTSKRNVQRN---SPGEAQEDDIHKNLPAIPMQYADSLQGLDKG 728

  Fly  1144 ---SVRE------SPRMVSKRDRDRERP-----------PINGLGAGHF 1172
               .|:|      |...|....|..|.|           |.|.....||
 Frog   729 GCQEVKELKGKQRSYGSVPSAQRSAEEPLPDPVAPDKDKPQNRTVTSHF 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	51/330 (15%)
		HNOBA	<833..881	CDD:462234	16/47 (34%)
		CYCc	860..1052	CDD:214485	98/191 (51%)
gucy1b2	XP_017949923.2	HNOB	21..182	CDD:462233	10/39 (26%)
		HNOBA	280..469	CDD:462234	52/291 (18%)
		CYCc	448..633	CDD:214485	97/188 (52%)