DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc76C and npr3

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_004910476.1	Gene:	npr3 / 100495974	XenbaseID:	XB-GENE-1012470	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	568	Identity:	119/568 - (20%)
Similarity:	222/568 - (39%)	Gaps:	147/568 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGL-AISGALTMALDEVNKDPNLLPNVYLDL 71
            |.|::::.:...||.....||..|..|..|......: .:..|:..||..:.::..|||.::.::
Frog     7 LSLMVTLVILAKSNPVDEDTVNMLVLLPKDNSYMFSMDRVRPAVDHALRSIQENQTLLPGMHFNV 71

  Fly    72 RWNDTK-GDTVLATKAITEMICDGIATIFGPEGPC-YVEAIVSQSR---NIPMIS---------Y 122
            .:||:. |:..|.:.....|.......|.||  .| |..|.|::..   |:||:|         .
Frog    72 IYNDSDCGNQALFSLIDIAMQLQKPDVILGP--VCEYAAAPVARLASHWNVPMLSAGALAIGFMQ 134

  Fly   123 KCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTI 187
            |..||     ....|..|..:::.:..||:.||:.|.|..:||.|
Frog   135 KSNEY-----SHLTRVSPVYSKMGEMFLAMFRYHKWTKAFLLYTD-------------------- 174

  Fly   188 NHKQSFIDNRVKCCEQMLDCC-----RSGYWY--------------QLVQNTMNRTRIYVFLGAA 233
                   ||..:.|...|:..     ..||..              ::|.:..|:.|:.:...::
Frog   175 -------DNLQRNCFFTLEGVHLAFKEEGYAMSIHNFDETKHVDAEEIVHSIQNKERVVIMCASS 232

  Fly   234 NSLVDFMSSMETAGLFARGEYMVIFVDMM---VY---SEREAEKYLRRVDQITFMSNCHSTENFN 292
            :::.:.|.:....|: ..|:|:...:::.   .|   |.:..:||           :..:.:.::
Frog   233 DTVRNIMLAAHRQGM-TNGDYVFFNIELFNSSTYGNGSWKRGDKY-----------DLEAKQAYS 285

  Fly   293 QMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLY 357
            .:....|:....|   ::.:|:.:|:  ||.....|         |...:::::....:|::.||
Frog   286 SLQTVTLLRTVKP---EFEKFSMEVK--SSVQKLGL---------NEDDYVNMFVEGFHDAIILY 336

  Fly   358 AWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAY 422
            |.|:.::|:....          ..:|.:::.. :.||||..|.| ::.||..||..|:|||:|
Frog   337 ALALHELLKNGFS----------KKDGEKLVQQ-MWNRTYEGIAG-QVSIDANGDRYGDFSVIA- 388

  Fly   423 KPHKWNNSNNMPCNYHMVPVAYFHQG--EEHPEYK--------LINGSIDWPSGGEKPADEPMCG 477
            ...|...:..:..:|:.:      ||  |..|..|        |||..|     .|.|:..|
Frog   389 MTDKETGTQEVIGDYYGI------QGHFEIRPNVKPPWGPGRLLINERI-----VEHPSTTP--- 439

  Fly   478 FANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIY---RKWKIELE 522
                 ||.......|.|..:|:|..| .:|:: |:.|   :|::|.:|
Frog   440 -----CKSSGGLGESAVTGIVVGAFL-GTGLL-MAFYFFRKKYRITIE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	90/458 (20%)
		ANF_receptor	48..412	CDD:279440	76/402 (19%)
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003
		CYCc	860..1052	CDD:214485
		Guanylate_cyc	887..1074	CDD:278633
npr3	XP_004910476.1	PBP1_NPR_C	25..414	CDD:380609	93/467 (20%)
npr3	XP_004910476.1	TM_EphA1	443..474	CDD:391457	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910