Protein Alignment Gyc76C and gucy2f

DIOPT Version :9

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_002931862.2
• Gene: gucy2f / 100492820
• XenbaseID: XB-GENE-480268
• Length: 1112
• Species: Xenopus tropicalis
• Alignment Length: 1152
• Identity: 362/1152 - (31%)
• Similarity: 570/1152 - (49%)
• Gaps: 218/1152 - (18%)

  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIF-GPEGPCYVEA--I 110
            |..:|::.:|||.:|  ::.|...:...:.|...:....|.:...|:|:.| ||..|.|.:|  :
 Frog    79 AAKLAIERINKDASL--DLGLSFNYVILEEDCQTSKALSTFLTYSGVASGFIGPSNPGYCDAATL 141

  Fly   111 VSQSRNIPMISYKCAEY---RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVW- 169
            :.::.|..:.|:.|..|   ...:.||||||.|..|:|   |..:::|:.|....::  .||:|
 Frog   142 LGKNWNKAVFSWACINYELDNVKSYPTFARTLPSPTRV---LFNVMKYFQWAHVGVISSNEDIWR 203

  Fly   170 ---SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLG 231
               ..||:.|:.......:.::     :.:.::..:|.|:..|.....:::...|:.    |.:|
 Frog   204 DTGRKVANALRSNGLPVGIVVS-----MGDDIRSTQQALEKVRKIDNIRMIIMCMHS----VLIG 259

  Fly   232 --AANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQM 294
              |...|::....::    ...|.|:.:..|.:.||    ..|.:     |......::.|....
 Frog   260 GQAQQRLLEVAHDLK----MTDGTYVFVPYDTLYYS----LPYHK-----TTYDMLKNSPNLTAA 311

  Fly   295 ARSLLVVASTPPTKDYIQFTKQVQKYSS-----KPPFNLEIPRLFVESNFSKFISIYAAYLYDSV 354
            ..|:|.:......|.:.:..::.|:...     ||.   ::..||             ..:|:::
 Frog   312 YDSVLTITVESEGKTFYEAFQEAQESGEMNANIKPS---QVSPLF-------------GTIYNAI 360

  Fly   355 KLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSK--IKIDQYGDSEGNF 417
            ...|:|::...|:.|.|           :|:    :::|:...|...|..  ||.|..|:...::
 Frog   361 YFTAYAMNSSRRQGTWV-----------SGS----SLVKHSKNMQFYGFNQWIKTDMSGNGFTDY 410

  Fly   418 SVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEY---------KLINGSIDWPSGGEKPADE 473
            .:|         ..:|..|            |.|..|         :.:...|.:|: |..|..:
 Frog   411 VIL---------DADMKTN------------ELHRTYVVDMETDMVRYMGRPIHFPN-GVSPKTD 453

  Fly   474 PMCGFAN-ELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDP--NEI 535
            ..|.|:: ::|       |..:......::..|   |.::|       :.:.||.:.|..  |:|
 Frog   454 SYCWFSDGKIC-------TGGIEPAFALMVFLC---IVVAI-------ISLNGLAYVIRRRINKI 501

  Fly   536 KGYSGNEIVSSPSKV--------------SLMSAQSYGSRWTNQ--FVTSTGRLR---------- 574
            |      :|..|:|:              |:....:.|||.::.  .:|.|..::
 Frog   502 K------LVRGPNKILLTLEDVTFINPQLSVKKLSNDGSRTSDSGPVLTDTRSMKSPMRSGSTQS 560

  Fly   575 ---------------GAVVRIK--------ELKFPRKRDISREIMKEMRLLRELRHDNINSFIGA 616
                           |..|.:|        ||| |...|:. |.||:|      ||:|:|.|:|.
 Frog   561 LIPATYENSNVAIYEGDWVWMKKFPSGDFGELK-PGTSDVF-ETMKDM------RHENVNPFLGF 617

  Fly   617 SVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNC 681
            ..:.....:||::|::|||.|::.|:|:|||.:|.:||:.||||||.|:|:.:.| ||.|||.||
 Frog   618 FHDCGVFAIVTEFCSRGSLEDLLRNQDVKLDWMFKSSLLLDLIKGMKYLHHRKFV-HGRLKSRNC 681

  Fly   682 VVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLR---NHIHGSQKGDVYAFAII 743
            ||..|::|:|||:|.:|:.: |:.....|...| ..||.||||||   :.:|||..||||:|::|
 Frog   682 VVDGRFVLKVTDYGYNEVLE-AQRIPHEEPTAY-ELLWTAPELLRDPLSAVHGSFSGDVYSFSVI 744

  Fly   744 MYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDP 808
            |.|:..|..||..:....:||:..|||.|        |....::..:..|...:..::.||.|.|
 Frog   745 MQEVVVRGPPFCTVEDTAEEIIQKVKKPP--------PLCRPMVSPDHAPMECIILMKKCWNEVP 801

  Fly   809 EERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRML 873
            :.||.|..|.::.|.:..|:..||:|.|:.|:|:|::||||::.|||..|..||.|||.||.:||
 Frog   802 DRRPSFDEIFDQFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQML 866

  Fly   874 PQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVY 938
            |.||||.|.||..|||..:|.||:|||||||||::||.|.|::||:.||||||:||.:|..:|||
 Frog   867 PPSVAEALKMGCTVEPEGFDEVTLYFSDIVGFTSISAMSEPIEVVDLLNDLYTLFDAVIGNHDVY 931

  Fly   939 KVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAG 1003
            |||||||||||.||||.:||:|||.|||:|:|::|.:|...::.|.|:..:::|||:|:||.|||
 Frog   932 KVETIGDAYMVASGLPKRNGNRHAAEIANMSLDILSSVGSFKMRHMPDVPVRIRIGLHSGPAVAG 996

  Fly  1004 VVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVV 1068
            ||||||||||||||||||||||||.|...:||::......|..|..||:.|.||...:||||...
 Frog   997 VVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVKTLRSLNEGYLLELRGRTELKGKGIEE 1061

  Fly  1069 TWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQA 1115
            |:||.|      ::.....:.:||.:     ||.::.....|..|.|
 Frog  1062 TFWLVG------KEGFTKPLPVPPVI-----KSGQMGHGLLQDEITA 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	80/416 (19%)
		ANF_receptor	48..412	CDD:279440	76/383 (20%)
		PK_GC-A_B	543..827	CDD:270944	109/335 (33%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	118/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	112/186 (60%)
gucy2f	XP_002931862.2	PBP1_sensory_GC_DEF-like	58..439	CDD:380594	83/438 (19%)
		PK_GC-2D	553..820	CDD:270945	100/285 (35%)
		HNOBA	<829..874	CDD:400168	26/44 (59%)
		CYCc	853..1044	CDD:214485	117/190 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9642
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000