Protein Alignment Gyc76C and adcy1

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_002933461.1
• Gene: adcy1 / 100492373
• XenbaseID: XB-GENE-950909
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1025
• Identity: 199/1025 - (19%)
• Similarity: 350/1025 - (34%)
• Gaps: 341/1025 - (33%)

  Fly   213 WYQLVQN-----TMNRTRIYV-----------FLGAANSLVDFMSSME--------TAGLFARGE 253
            |..||.|     ::|.:.::|           ||.|.|.:.|.:...:        ...|..|..
 Frog   201 WRTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNV 265

  Fly   254 YMVIFVDMMVYSEREAEK-YLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQV 317
            .|.:..|.:...||...| |::|.|.::.:                        ..|.:.||...
 Frog   266 AMEMKEDFLKPPERIFHKIYIQRHDNVSIL------------------------FADIVGFTSLA 306

  Fly   318 QKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYA---WAVDKMLREETRVLTDDVIFE 379
            .:.:::     |:.:|..|. |.||..:........:|:..   :.|..:.:.:|     |....
 Frog   307 SQCTAQ-----ELVKLLNEL-FGKFDELATENHCRRIKILGDCYYCVSGLTQPKT-----DHAHC 360

  Fly   380 VASNGTRVIDTI--IKNRTYMSI-------TGSKIKIDQYGDSEGNFSVLAYKPHKWNN------ 429
            ....|..:||||  :...|.:.:       || ::.....|..:..:.|       |:|
 Frog   361 CVEMGLDMIDTITSVAEATEVDLNMRVGLHTG-RVLCGVLGLRKWQYDV-------WSNDVTLAN 417

  Fly   430 ---SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGF-ANELCKKDD--- 487
               :..:|...|:.          ....:.:||..:         .||..|. .|...||.:
 Frog   418 VMEAGGLPGKVHIT----------KNTLECLNGDYE---------VEPGYGHERNSFLKKHNIET 463

  Fly   488 -----THYTSTVAAVVLGVL---------LFCSGVITMSIYRK-WKIELEIEGLLWKIDPNEIK- 536
                 :|.......::|..:         ..|..::.:...|| :|.|:....::...|.::.:
 Frog   464 FFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRA 528

  Fly   537 ------------GYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKR 589
                        .:|.|.|.::|           |:| .|:::   |||..|.....|:.
 Frog   529 LRTASEKLRNRSSFSTNVIHNTP-----------GTR-VNRYI---GRLIEARQTDSEMS----- 573

  Fly   590 DISREIMKEMRLLRELRHDNINS--FIGASV------------------EPTRILLVTDYCA--- 631
            |::...:|...:.||.::..::.  |..|.|                  :.|.:|::..:|.
 Frog   574 DLNFITLKYKHIEREQKYHQLHDEYFTSAVVLSLILAALFGLVYLLIFPQSTIVLILLVFCLCFL 638

  Fly   632 ---------------KGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNC 681
                           .|.|  .|:...|..  :||..||:.:.:|.: :.....::..|..||..
 Frog   639 VACIMYLHVTRVQCFPGCL--TIQIRTILC--IFIVILIYSVAQGCV-VGCMPWIWRSNNSSSIV 698

  Fly   682 VVTSRWMLQVTDFGLHELRQCAENESIGEH----QHYR------NQLWRAPELLRNHIHGSQKGD 736
            ::|.:                .||:::.|.    .||.      ..|..|..|   .|....|..
 Frog   699 IITPK----------------GENKTMNERPCDTAHYTFLSCVVGTLSLAIFL---RISSFPKMV 744

  Fly   737 VYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLP-----LKGEDPFRPEVESIIEAESCP--- 793
            :..|..|:|.:.             .||..|.|.|.     ::|.:|.     ..|...||.
 Frog   745 LLLFVTILYIVI-------------LEISGYRKTLGGDTSYMRGYEPI-----LAILLFSCSLAL 791

  Fly   794 -----------DYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNL 847
                       ||:       ||...||.                     .|.|
 Frog   792 HSRQVDLKLRLDYL-------WAVQAEEE---------------------RDDM----------- 817

  Fly   848 EDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTM----GQGVEPVSYDLVTIYFSDIVGFT-- 906
                 ||.      |:..:.:|..:||..||:...|    ...:...||..|.:.|:.|..|.
 Frog   818 -----ERV------KLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDF 871

  Fly   907 --AMSAESTPLQVVNFLNDLYTVFDRIIRG---YDVYKVETIGDAYMVVSGLPIKNGDR------ 960
              .:...:..::.:..||::...||.::..   .|:.|::|||..||...||....|.:
 Frog   872 YIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIY 936

  Fly   961 -HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASR 1024
             |...:|..::|:...:.:  |.::......||:|::.|||||||:|...|:|.::|:|||.|||
 Frog   937 SHLSTLADFSIEMFDVLDE--INYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASR 999

  Fly  1025 MESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |:|.|...||.::......|......::.  ||.|::||||:::|::|.|
 Frog  1000 MDSTGVQGKIQVTEDVHRILKSCNYEFVC--RGKVSVKGKGEMLTYFLEG 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	48/277 (17%)
		PK_GC-A_B	543..827	CDD:270944	62/350 (18%)
		HNOBA	<833..881	CDD:462234	10/47 (21%)
		CYCc	860..1052	CDD:214485	57/209 (27%)
adcy1	XP_002933461.1	AcyC	96..446	CDD:441717	50/306 (16%)
		Guanylate_cyc	284..466	CDD:425528	38/243 (16%)
		Adcy_cons_dom	510..599	CDD:461877	18/108 (17%)
		PGAP4-like	<580..>642	CDD:471077	9/61 (15%)
		putative TM2 helix	599..618	CDD:409189	3/18 (17%)
		putative TM3 helix	629..642	CDD:409189	1/12 (8%)
		Guanylate_cyc	850..1047	CDD:425528	59/200 (30%)