DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and LOC100489435

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_017947350.2	Gene:	LOC100489435 / 100489435	-ID:	-	Length:	1106	Species:	Xenopus tropicalis

Alignment Length:	1205	Identity:	382/1205 - (31%)
Similarity:	570/1205 - (47%)	Gaps:	238/1205 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPFNL---LLLLSVAVR----DCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVN 58
            :||::   .||:.|.:.    ||.|    .|||.:.....|   .|....|    |..:|:.::|
Frog    31 FPFSIPSWWLLMGVFMNSLGVDCKN----FTVGVVGPWQCDPLFSKAFPEL----AARLAVQKIN 87

  Fly    59 KDPNLLPNVYLDLRWNDTKGDTVLATKAITEMIC-DGIATIF-GPEGPCYVEA--IVSQSRNIPM 119
            .|..|......|.|......:|   :||:.:... |..::.| ||..|.|.:|  ::.::.:..:
Frog    88 NDATLGIGYKFDYRILQENCET---SKALVDFSSYDKHSSAFVGPMNPGYCDAATLLGKNWDKAV 149

  Fly   120 ISYKCAEY---RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVW----SPVADL 175
            .|:.|..:   ..|:.||||||.|..|:|   |...::|:.|....|:  .:|:|    ..||..
Frog   150 FSWACINHDLDDKSSFPTFARTMPAPTKV---LFHFMKYFRWAHVGIVSSNDDLWVDTGRKVASA 211

  Fly   176 LKD------------------QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMN 222
            |::                  :||..|:...|     |.||     ::.|..|
Frog   212 LRNHGLPIGIVTSMGNGEEGLRATLANIEEAH-----DLRV-----IIMCMHS------------ 254

  Fly   223 RTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHS 287
                 |.:|.|.. ..|::.....|| ..|.|:.:..|.::||             :.:.::.:.
Frog   255 -----VLIGGAEQ-ATFLTQAHEMGL-TDGRYVFVPYDTLLYS-------------LPYKNSSYQ 299

  Fly   288 TENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVE---------SNFSKFI 343
            ....|...::......| .|.||               .||....:|.|         |...:.:
Frog   300 VLEKNPELKAAYDAVLT-ITMDY---------------ENLSFYEVFAEAKERGEIKTSVEPQQV 348

  Fly   344 SIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKID 408
            |.....:|:::.|.|.|:....::...|           :||.::| ..||..|...| ..:..|
Frog   349 SPLFGTIYNAMYLLAKAMSSAWKQGAWV-----------SGTNLVD-YAKNLEYPGFT-QTLYTD 400

  Fly   409 QYGDSEGNFSVL--------AYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPS 465
            ..|:...||.||        .:..:....|:|:                    .:.:..:|.:|
Frog   401 GKGNDLSNFVVLDTDGKVNQLFPTYSVEMSSNL--------------------VRFLGKTIRFP- 444

  Fly   466 GGEKPADEPMCGF-ANELCKKDDTHYTSTVAAVVLGV---LLFCSGVITMSIYRKW--------- 517
            ||..|..:..|.| .:.||......|   :..::.|:   |..| ||:...:.|..
Frog   445 GGTPPPSDSSCWFDPDTLCIGGIEPY---IVILIFGLVFALALC-GVVVSYLIRHSILQIQLVKG 505

  Fly   518 --KIELEIEGLLWKIDPN------EIKGYSGNEIVSS----PSKVSLMSAQSYGSRWTNQFVTST 570
              ||.|.::.|.: |:|.      .|...|..:.:|.    .|....:||:|.|:   :...:|.
Frog   506 PNKILLSLDDLTF-INPKLSMKKLNIDNISDTKSISDCKSLKSLTRSLSAKSLGA---SHETSSV 566

  Fly   571 GRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSL 635
            ....|..|.:|:.:.....::.:.....:|.:::||::|:|.|:|...:.....:||::|::|||
Frog   567 AIYEGDWVWLKKFEPGVYHELRQSTTSTLRKMKDLRNENVNPFLGFFSDCGIFAIVTEHCSRGSL 631

  Fly   636 YDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELR 700
            .|::.|||:|||.:|.:||:.||||||.|:|:... .||.|||.||||..|::|::||:|.:|:
Frog   632 EDLLRNEDVKLDWMFKSSLLLDLIKGMRYLHHRDF-SHGRLKSRNCVVDGRFVLKITDYGYNEV- 694

  Fly   701 QCAENESIGEHQHYRNQL-WRAPELLRNHI---HGSQKGDVYAFAIIMYEIFSRKGPFGQINFEP 761
              .|.:....:.....:| |.||||||:..   .|:.||||::||||:.|:..|..|:.......
Frog   695 --VETQKSPRYSMPPEELFWTAPELLRDQALSRRGTFKGDVFSFAIILQEVVVRGPPYCTSGLSA 757

  Fly   762 KEIVDYVKKLPLKGEDPF-RPEVESIIEAESCPDYV-LACI---RDCWAEDPEERPEFSVIRNRL 821
            :||:..|||.|     |. ||.|        .||.. |.||   :.||:|..|.||.|..|.::.
Frog   758 EEIIRKVKKPP-----PLCRPAV--------APDQAPLECIQLMKQCWSELAERRPTFDEIFDQF 809

  Fly   822 KKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQG 886
            |.:..||..||:|.|:.|:|:|::||||::.|||..|..||.|||.||.:|||.||||.|..|..
Frog   810 KTINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQKTEKLLSQMLPPSVAEALKTGGT 874

  Fly   887 VEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVS 951
            |||..:|.||||||||||||.:||.|.|::||:.||||||:||.::..:||||||||||||||.|
Frog   875 VEPEYFDHVTIYFSDIVGFTTISALSEPIEVVDLLNDLYTLFDAVLCNHDVYKVETIGDAYMVAS 939

  Fly   952 GLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFG 1016
            |||.:||:||..|||:|:|::|.:|...::.|.|:..:::|||:|:||.||||||||||||||||
Frog   940 GLPKRNGNRHTAEIANMSLDILSSVGSFQMRHMPDVPVRIRIGLHSGPCVAGVVGLTMPRYCLFG 1004

  Fly  1017 DTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQ 1081
            |||||||||||.|...:||::......|..|...|..|.||...:||||...|:||.|  :....
Frog  1005 DTVNTASRMESTGLPYRIHVNQSTAAILRTLNERYKIELRGKTELKGKGVEETFWLVG--KEGFS 1067

  Fly  1082 KKLVDMMDMPPPL------------FSRPRKSPKL 1104
            |.|....|:.|..            |.| ||:.||
Frog  1068 KPLPRPPDIKPGCVAHGLTAEEVAEFKR-RKAAKL 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	95/469 (20%)
		ANF_receptor	48..412	CDD:279440	82/403 (20%)
		PK_GC-A_B	543..827	CDD:270944	101/296 (34%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	115/191 (60%)
		Guanylate_cyc	887..1074	CDD:278633	110/186 (59%)
LOC100489435	XP_017947350.2	PBP1_sensory_GC_DEF-like	57..438	CDD:380594	95/481 (20%)
		PK_GC-2D	550..815	CDD:270945	99/284 (35%)
		HNOBA	<824..869	CDD:400168	26/44 (59%)
		CYCc	849..1041	CDD:214485	116/191 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9642
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000