DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc76C and npr2

DIOPT Version :9

Sequence 1:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_031750866.1	Gene:	npr2 / 100488543	XenbaseID:	XB-GENE-993191	Length:	1083	Species:	Xenopus tropicalis

Alignment Length:	1094	Identity:	410/1094 - (37%)
Similarity:	592/1094 - (54%)	Gaps:	162/1094 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISGALTMALDEVNKDPNLLPN-----VYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPC 105
            ::.||.||:|....:..|||.     |:|....|....:.|....|:...:......:||| |..
Frog    79 VAPALRMAMDRAQGELQLLPGYQVKWVFLTSELNGACSEYVAPLNAVDLKLYHNPDVLFGP-GCV 142

  Fly   106 YVEAIVSQSR---NIPMISYKCAEYRASAIP-----------TFARTEPPDTQVVKSLLALLRYY 156
            |..|.|::..   .:|:|:       |.|:.           |..||.|...::.:.:..|..::
Frog   143 YPSASVARFATHWRLPLIT-------AGALAFGFKQDDDHYNTTVRTGPTAIKLGEFVSHLHEHF 200

  Fly   157 AW-NKFSILYEDVWSPVAD----------LLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRS 210
            .| ::.:::|.||  .:.|          .|.......|:|::::....|..:
Frog   201 NWSSRAALVYHDV--KMDDRPHYFIIEGVFLALNKEFNNLTVSYQMYPEDEDI------------ 251

  Fly   211 GYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSE-------RE 268
            |...|.:||:   .|:....|....|...|...:...| ..|:|:..:||  |:.|       ||
Frog   252 GSVIQFIQNS---GRVIYICGPLEMLHLIMLQAQREKL-TDGDYVFFYVD--VFGESLRADGARE 310

  Fly   269 AEKYLRRVDQITFMSNCHSTENFNQMARSLLVVA-STPPTKDYIQFTKQ-VQKYSSKPPFNLEIP 331
            |.|        .:..| ||.| ..:..:::||:: ..|...:|.:|.|: :||  ||..|.:|:
Frog   311 ANK--------PWQGN-HSQE-LKEAFKTVLVISYHQPENAEYFEFQKKLIQK--SKEEFGVEL- 362

  Fly   332 RLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRT 396
                  ||| .::..|...:|.|.|||.|:::.|||...          ..:|..::.. |::|.
Frog   363 ------NFS-LMNFIAGCFHDGVLLYAQALNETLREGGS----------QKDGLSIVKK-IQDRQ 409

  Fly   397 YMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSI 461
            ...|||: :.:|:..|...:|.:.|...|   |..:.....|               |..||..|
Frog   410 MEGITGT-VSMDKNNDRNTDFDLWAMTDH---NEGSFEVVGH---------------YNGINKQI 455

  Fly   462 DWPS------GGEKPADEPMCGF--ANELCKKDDTHYTSTVAAVVLG----VLLFCSGVITMSIY 514
            :|..      .|..|:|.|.|.|  .:..|.|..   .||:|.|.||    :|:|  |:.:..|.
Frog   456 NWTGKPILWLKGSPPSDSPPCVFNADDPSCLKTT---VSTLAIVALGAGLTLLIF--GMSSFLIL 515

  Fly   515 RKWKIELEIEGLLWKIDPNEIK-GYSGNEIVSSPSKVSL-MSAQSYGSRWT----NQFVTSTGRL 573
            ||..:|.|:..:||:|...|:: |.|.....::.|:::| :...||||..|    .|...:||..
Frog   516 RKLMLEKELASMLWRIRWEELQFGNSERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHF 580

  Fly   574 RGAVVRIKELKFPRKR-DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD 637
            :|.||.||.:.  :|| :::|:::.|::.:|:::.:::..|:||.::|..|.:||:||.:|||.|
Frog   581 KGNVVAIKHVN--KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQD 643

  Fly   638 IIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQC 702
            |:|||.|.||.:|..|||:|::|||.::|.|.:..|||||||||||.||::|::||:||...|..
Frog   644 ILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSS 708

  Fly   703 AENESIGEHQHYRNQLWRAPELL---RNHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPK 762
            .|.:.  .:..|..:||.|||||   |....|:||||||:|.||:.||..|.|.|  ..::..||
Frog   709 CEADD--AYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPK 771

  Fly   763 EIVDYVKKLPLKGEDP-FRPEVESIIEAESCPDYVLACIRD-CWAEDPEERPEFSVIRNRLKKMR 825
            |||..|:    .|:.| |||.|:.     ||....|..:.| ||||:|.:||:|:.|:..:.|..
Frog   772 EIVQKVR----NGQRPYFRPTVDI-----SCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFN 827

  Fly   826 GGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPV 890
            ...:.:|:|.::..||:||||||.:|.|||:...|||.|.|:||:::||.||||:|..|:.|:..
Frog   828 KEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAE 892

  Fly   891 SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPI 955
            ::|.||||||||||||:|||||||:|||..||||||.||.||..:|||||||||||||||||||:
Frog   893 AFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPV 957

  Fly   956 KNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN 1020
            :||..|..|||.|:|.||.||:..:|.||||..|:||||:|||||.||||||.||||||||||||
Frog   958 RNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN 1022

  Fly  1021 TASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            ||||||||||||:||||:..|..||:. ..:..|.||.:.|||||.:.|:||.|
Frog  1023 TASRMESNGEALRIHISSATKEVLDEF-SCFQLELRGDIEMKGKGKMRTYWLHG 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	99/437 (23%)
		ANF_receptor	48..412	CDD:279440	93/402 (23%)
		PK_GC-A_B	543..827	CDD:270944	120/296 (41%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	132/191 (69%)
		Guanylate_cyc	887..1074	CDD:278633	128/186 (69%)
npr2	XP_031750866.1	PBP1_NPR_B	60..458	CDD:380607	103/456 (23%)
		PK_GC-A_B	555..829	CDD:270944	118/286 (41%)
		HNOBA	<835..883	CDD:400168	26/47 (55%)
		CYCc	862..1046	CDD:214485	130/183 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000