Protein Alignment Gyc76C and gucy1b1

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001238874.1
• Gene: gucy1b1 / 100150304
• ZFINID: ZDB-GENE-090313-160
• Length: 608
• Species: Danio rerio
• Alignment Length: 644
• Identity: 184/644 - (28%)
• Similarity: 278/644 - (43%)
• Gaps: 155/644 - (24%)

  Fly   516 KWKIELEIEG-LLWKIDPNEIKGYSGNEIVSSPSKVSLMSA----QSYGSRWTNQFVTSTG---- 571
            |.:.::::|| .|.:|...:.|.|   ::|::.|||..|.|    |.:|..:. :|...:|
Zfish    26 KREAQVDVEGQFLVRIIYEDAKTY---DLVAAASKVLKMDAGGILQMFGKMFF-EFCQESGYDTI 86

  Fly   572 -RLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNIN---------SFIGASVEPTRILLV 626
             |:.|:.|              ||.::.:..|    ||::.         ||.....|....|::
Zfish    87 LRVLGSNV--------------REFLQNLDAL----HDHLGTIYPGMRAPSFRCTDAEKGNNLIL 133

  Fly   627 TDYCAKGSLYDI-----------IENEDIKLDDLFIASLIHDLIKGMIYIHNS-QLVYHGNLKSS 679
            ..|..:..|.||           |...:|::..:...|...|.||.:|...:| :..::.:|...
Zfish   134 HYYSEREGLQDIVIGIIKTVAQQIHGTEIEMKVIQPKSEECDHIKFLIEEKDSEEEAFYEDLDGF 198

  Fly   680 NCVVTSRWMLQ----VTDFGLH-------ELRQCAENESIGEHQHYRNQLWRA-PE--------- 723
            ....|....:.    ...|..|       .|.||.            |.::|. |:
Zfish   199 EENGTQETRISPYTFCKAFPFHLMFDKDLMLTQCG------------NAIFRVLPQLQPGVCNLS 251

  Fly   724 ----LLRNHIHGSQKGDVYAFAIIMY--EIFSRKGPFGQINFEPKEIVD-----YVKKLPLKGED 777
                |:|.||..|..|      |:.:  .:|..:...|.:|.|..|..|     .:..|.|||:.
Zfish   252 SVFSLVRPHIDFSFHG------ILSHINTVFVLRSKEGLLNVETAENEDELTGTEISCLRLKGQM 310

  Fly   778 PFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRG---------GKTKNIM 833
            ...||.|:|:         ..|.......|...|             ||         ..|::::
Zfish   311 ISLPETENIL---------FLCSPSVMNLDDLTR-------------RGLYLSDIPLHDATRDLV 353

  Fly   834 DQMMEMMEKYANNLE-DIVTER----TRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYD 893
            ....:..|:|....| :|:|:|    .|.|.:||.||:.||:.:||.|||.:|...:.|....||
Zfish   354 LLGEQFREEYKLTQELEILTDRLQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYD 418

  Fly   894 LVTIYFSDIVGFTAM-----SAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVV 950
            .|||.||.||||.|.     |||.. :::||.|||:||.||.:.   :...||||||:||.||.|
Zfish   419 NVTILFSGIVGFNAFCSKHASAEGA-IKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTV 482

  Fly   951 SGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLF 1015
            |||| :....||..|..:||:::....|.::...|   :::.||:|||.||.||:|..|||||||
Zfish   483 SGLP-EPCTHHAKSICHLALDMMEIAGQVKVDEDP---VQITIGIHTGEVVTGVIGQRMPRYCLF 543

  Fly  1016 GDTVNTASRMESNGEALKIHISN---KCKLALDKLGGGYITEKRGLVNMKGKGDVVTWW 1071
            |:|||..||.|:.||..||::|.   :|..:::.....:..|.||.|.||||.:.:..|
Zfish   544 GNTVNLTSRTETTGEKGKINVSEYTYRCLQSVENADPQFHLEYRGPVTMKGKKEPMKVW 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	70/354 (20%)
		HNOBA	<833..881	CDD:462234	19/52 (37%)
		CYCc	860..1052	CDD:214485	89/202 (44%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:462233	35/161 (22%)
		HNOBA	207..406	CDD:462234	54/238 (23%)
		Guanylate_cyc	412..605	CDD:425528	86/196 (44%)