DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and gria1a

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	534	Identity:	119/534 - (22%)
Similarity:	208/534 - (38%)	Gaps:	135/534 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KGRQLG-----GELNITADREI-FCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTAL 200
            |||:..     .||..|..::: :.|:.    |:::|   |.:.:.......||..|...|.|.|
Zfish   356 KGRRTNYSISVMELRPTGPKKVGYWNED----EKFVS---TAAYMPGSNETYGLQNRTYIVTTIL 413

  Fly   201 --PLNVSIKEIFDFM--NSKY-----RIQLDTYARLGYQARQPLRDMLDCKFKYIFRD----RWS 252
              |. |.:|:..:..  |.||     .:..:....:||  ...|:.:.|  .||..||    .|:
Zfish   414 ESPY-VMLKKNHEHFTGNDKYEGYCVELAAEIAKHVGY--HYILKIVAD--GKYGARDAETMMWN 473

  Fly   253 DGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSAT 314
                  ||:|:|:..|||:|:||...:..|..   |.:|.....:   ..|.:.|.....|:.:
Zfish   474 ------GMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPTKSKPGVFS- 528

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLW-------VTFILERRK--QW--------------KPS-- 354
             ||.|.:..:|:          |:::       |.|::.|..  :|              :||
Zfish   529 -FLDPLAYEIWM----------CIVFAYIGVSVVLFLVSRFSPYEWHADDCEDGAEENPNQPSSS 582

  Fly   355 -----------------------LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALMVTS 391
                                   :..|...|.||...||..::|||:.||:.     ||.|::.|
Zfish   583 SAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIIS 647

  Fly   392 YLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK 454
            ....|....:.|.::: .||:|  ::....::|...||.|.....:.|..:...|
Zfish   648 SYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIAVFE---------- 701

  Fly   455 KVLGSKRSPD-KIWI-PTEAGVLSVRDQEG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-D 515
            |:....:|.| .::: .|:.||:.||..:| :.|:. .:|..|::.:    .:.|:..::... |
Zfish   702 KMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLL-ESTMNEYIEQ----RKPCDTMKVGGNLD 761

  Fly   516 ASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAA 575
            :........|.||....:.|:.|::.|.|:..|.:..|...|..|     ...:.|.|:.|...|
Zfish   762 SKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVA 826

  Fly   576 PLFIILLGAIILCM 589
            .:|.||:|.:.|.|
Zfish   827 GVFYILIGGLGLAM 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	75/361 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	64/298 (21%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	8/34 (24%)
		ANF_receptor	36..369	CDD:279440	3/12 (25%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	96/443 (22%)
		Lig_chan	536..836	CDD:278489	67/325 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740