Protein Alignment Ir75b and gria1a

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 534
• Identity: 119/534 - (22%)
• Similarity: 208/534 - (38%)
• Gaps: 135/534 - (25%)

  Fly   142 KGRQLG-----GELNITADREI-FCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTAL 200
            |||:..     .||..|..::: :.|:.    |:::|   |.:.:.......||..|...|.|.|
Zfish   356 KGRRTNYSISVMELRPTGPKKVGYWNED----EKFVS---TAAYMPGSNETYGLQNRTYIVTTIL 413

  Fly   201 --PLNVSIKEIFDFM--NSKY-----RIQLDTYARLGYQARQPLRDMLDCKFKYIFRD----RWS 252
              |. |.:|:..:..  |.||     .:..:....:||  ...|:.:.|  .||..||    .|:
Zfish   414 ESPY-VMLKKNHEHFTGNDKYEGYCVELAAEIAKHVGY--HYILKIVAD--GKYGARDAETMMWN 473

  Fly   253 DGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSAT 314
                  ||:|:|:..|||:|:||...:..|..   |.:|.....:   ..|.:.|.....|:.:
Zfish   474 ------GMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPTKSKPGVFS- 528

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLW-------VTFILERRK--QW--------------KPS-- 354
             ||.|.:..:|:          |:::       |.|::.|..  :|              :||
Zfish   529 -FLDPLAYEIWM----------CIVFAYIGVSVVLFLVSRFSPYEWHADDCEDGAEENPNQPSSS 582

  Fly   355 -----------------------LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALMVTS 391
                                   :..|...|.||...||..::|||:.||:.     ||.|::.|
Zfish   583 SAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIIS 647

  Fly   392 YLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK 454
            ....|....:.|.::: .||:|  ::....::|...||.|.....:.|..:...|
Zfish   648 SYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIAVFE---------- 701

  Fly   455 KVLGSKRSPD-KIWI-PTEAGVLSVRDQEG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-D 515
            |:....:|.| .::: .|:.||:.||..:| :.|:. .:|..|::.:    .:.|:..::... |
Zfish   702 KMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLL-ESTMNEYIEQ----RKPCDTMKVGGNLD 761

  Fly   516 ASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAA 575
            :........|.||....:.|:.|::.|.|:..|.:..|...|..|     ...:.|.|:.|...|
Zfish   762 SKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVA 826

  Fly   576 PLFIILLGAIILCM 589
            .:|.||:|.:.|.|
Zfish   827 GVFYILIGGLGLAM 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	17/51 (33%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	19/68 (28%)
		Lig_chan	343..584	CDD:459656	63/297 (21%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_type1	26..390	CDD:471960	9/40 (23%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	96/443 (22%)
		Lig_chan	536..835	CDD:459656	66/324 (20%)