DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Grid2

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	141/708 - (19%)
Similarity:	249/708 - (35%)	Gaps:	199/708 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SKNIFTQFQPLHSDIQLN--DDFLNHNILKLGVFLDINCDKSGTVLDMASAKRFFSH-------- 91
            :|.|.|.|..:..: :||  .|.|...||               |::.|:||.|.|.
  Rat   205 NKMITTLFDTMRIE-ELNRYRDTLRRAIL---------------VMNPATAKSFISEVVETNLVA 253

  Fly    92 -RYHWLIYDRSMN--------------FSVLESHFKEAQIFVD---------ADVTYVTHDPFSK 132
             ..||:|.:..:|              .:::...|...|....         :.......|||::
  Rat   254 FDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQ 318

  Fly   133 N------------FLLYDVYNK-------------------------GRQL------GGELNITA 154
            |            .||.:.::|                         ||.:      ||...:|.
  Rat   319 NMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG 383

  Fly   155 DREIFCNKTNCRVE------RYLSEL-------------------YTRSALQHRKSFTGLTMRAT 194
            |.|...|..|..|.      .|..||                   .|...|::  :..|:.:|
  Rat   384 DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN--NMRGVVLR-- 444

  Fly   195 AVVTAL--PL-----NVSIK---------EIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKF 243
             |||.|  |.     ||..|         ::.|.:::......:.|....::...|..|
  Rat   445 -VVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQED------ 502

  Fly   244 KYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVS 308
                 ..|:      |::|:|:..:||:.|:....:.||...:...|::..:....:.|.....
  Rat   503 -----GTWN------GLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKT- 555

  Fly   309 AGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKPSLLTSCLLS-----FGAGCI 368
              :.....|.||...:|...|..:||.|.|:::...|...:....|:.::.|.:     :|:...
  Rat   556 --VDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQ 618

  Fly   369 QG-----AWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLA-DSNLD 427
            ||     ..|..|.|.|....|||:|.|     .||:.:.:.|....|:|:|::||.|: .:::.
  Rat   619 QGGEVPYTTLATRMMMGAWWLFALIVIS-----SYTANLAAFLTITRIESSIQSLQDLSKQTDIP 678

  Fly   428 VG--IEPTVYTRIYVETSEEPDVRD-LYRK--KVLGSKRSPDKIWIPTEAGVLSVR-DQEGFVYI 486
            .|  ::..||..:.:: ...|..|| :|.:  :::......:...:.::||:..|: ....||:.
  Rat   679 YGTVLDSAVYQHVRMK-GLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWD 742

  Fly   487 TGVATGYEFVRKHFLAHQICELNEIPLRDASHTHTV-LAKRSPYAELIKLSELRMLETGVH--FK 548
            ..|   .|:|.   :....|....:....|...:.: |...|||.::.....|.:.::|..  .|
  Rat   743 AAV---LEYVA---INDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILK 801

  Fly   549 HERSWMETKLHCYQHNHT------VAVGLEYAAPLFIILLGAIILCMGILGLEVIWHR 600
            |:  |......|..::..      .|:.::..|.:|.||...|:|...|..||..|.|
  Rat   802 HK--WWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	68/319 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	56/267 (21%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		29/155 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	42/239 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	84/402 (21%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740