DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grin2bb

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	480	Identity:	92/480 - (19%)
Similarity:	169/480 - (35%)	Gaps:	129/480 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYA 225
            |...||.:..|..|...|.:..::...|..:..            :|:|...:...|.:.|.|..
Zfish   511 NTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDI------------LKKIAKSVKFTYDLYLVTNG 563

  Fly   226 RLGYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPIT 290
            :.|.:                ....|:      ||:|:::|..|.:|:.....:.:|:    .:.
Zfish   564 KHGKK----------------INGTWN------GMVGEVVLKNAHMAVGSLTINEERS----EVI 602

  Fly   291 KFSV-FRE----ICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQ 350
            .||| |.|    :.:.|:..:|    |.:.||:|||..||:...::||:...:  ..|:.|   .
Zfish   603 DFSVPFIETGISVMVSRSNGTV----SPSAFLEPFSADVWVMMFVMLLIVSAV--AVFVFE---Y 658

  Fly   351 WKPSLLTSCLL--------SFGAGCIQGAWL------------------TPRSMGGRMAFFALMV 389
            :.|.....||.        ||..|  :..||                  |.:.|....||||::.
Zfish   659 FSPVGYNRCLADGREPGGPSFTIG--KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 721

  Fly   390 TSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK 454
            .:....|....::..:.:.|....:.:..|...|      ..|..........|.|.::|:.|::
Zfish   722 LASYTANLAAFMIQEEYVDQVTGLSDKKFQHPND------FSPPFRFGTVPNGSTERNIRNNYKE 780

  Fly   455 --------------KVLGSKRSPDKIWIPTEAGVLSV---RDQEGFVYITGVATGYEFVRKHFLA 502
                          :.|.|.:|........:|.||:.   || ||...:| :.:||.|....:
Zfish   781 MHSYMTSFHQKNVNEALHSLKSGKLDAFIYDAAVLNYMAGRD-EGCKLVT-IGSGYIFATTGY-- 841

  Fly   503 HQICELNEIPLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV 567
                             ...:.|.|.:...:.|:.|::...|...:.|..|: |.: |:...:.|
Zfish   842 -----------------GIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWL-TGI-CHNEKNEV 887

  Fly   568 ---AVGLEYAAPLFIILLGAIILCM 589
               .:.::..|.:|.:|..|:.|.:
Zfish   888 MSSQLDVDNMAGVFYMLGAAMALSL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	69/347 (20%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	52/287 (18%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	86/448 (19%)
		Lig_chan	636..908	CDD:278489	56/307 (18%)
		NMDAR2_C	919..1770	CDD:287527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830