Protein Alignment Ir75b and grik4

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 676
• Identity: 158/676 - (23%)
• Similarity: 256/676 - (37%)
• Gaps: 153/676 - (22%)

  Fly    16 AKLSHVLI-------------------LHCSLSHLALLA-QSKNI--FTQFQPLHSDIQLNDDFL 58
            |.:|||::                   |..||..|..|| |..||  |:.|...|...|   ||
Zfish   221 ATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDDLADQRVNIVGFSVFNRTHPFFQ---DF- 281

  Fly    59 NHNILKLGVFLDINCDK---SGTVLDMASAKRFFSHRYHWLIYD-------------RSMNFSVL 107
               :|.|......|||.   :||.|..|            |::|             ||.|....
Zfish   282 ---VLSLNRSWQENCDHAPFAGTPLSSA------------LLFDAVHTVVAAVQELNRSQNVGAT 331

  Fly   108 ESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGG-----ELNITADREIFCNK--TNC 165
            :...|.::|:        .|.....|:|      :..:|.|     |.|....|..:..:  .|.
Zfish   332 QLSCKSSKIW--------EHGTSLMNYL------RMVELEGLTGHIEFNSKGQRSNYALRIMQNS 382

  Fly   166 RVE-RYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQL---DTYAR 226
            |.. |.:.:.::...|...:....|.:..|...|.|.:...::..:..:.:.:: :|   |.|..
Zfish   383 RDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQ-ELEGNDRYEG 446

  Fly   227 LGYQARQPLRDMLDCKFKYIFRDRWSDG-----NATG---GMIGDLILDKADLAIAPFIYSFDRA 283
            ......:.|.|:|  ||||..| ...||     .|.|   ||:|:||..|||||:|....:.:|.
Zfish   447 FCVDMLKELADIL--KFKYRIR-LVGDGVYGVPGANGTWTGMVGELISRKADLAVAALTITAERE 508

  Fly   284 L---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTF 343
            .   |.:|...  .|:...:.:.|.|...|       ||.|||.||||...|..|...|:|   |
Zfish   509 KVIDFSKPFMTLGISIMYRVHIGRRPGYFS-------FLDPFSPGVWLFMLLAYLAVSCVL---F 563

  Fly   344 ILERRK--QW---KPSLLTSCLL---------SF----GAGCIQGAWLTPRSMGGR------MAF 384
            ::.|..  :|   .|.|...|.|         ||    |....||:.:.||::..|      .||
Zfish   564 LVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAF 628

  Fly   385 FALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSN-LDVGIEPTVYTRIYVETSEEPDV 448
            ..::::|      ||:.:.:.|..|.::..|.::..|||.. ::.|......|..:.:.|.....
Zfish   629 TLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTY 687

  Fly   449 RDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-P 512
            :.::  ..:.||: |......||.|:..|.: ..:.|:      .|.....:...:.|.|.:| .
Zfish   688 QRMW--NFMYSKQ-PSVFVKSTEEGIARVLN-SNYAYL------LESTMNEYYRQRNCNLTQIGG 742

  Fly   513 LRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAP 576
            |.|.......:...|.|.:...|:.||:.|.......:|.|.:......:.:|.. .:|:|....
Zfish   743 LLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWDGGKCPKEEDHRAKGLGMENIGG 807

  Fly   577 LFIILLGAIILCMGILGLEVIWH-RH 601
            :|::|:..:::.:.:..||.:|. ||
Zfish   808 IFVVLVCGLLVAIFMAVLEFVWMLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	23/55 (42%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	24/70 (34%)
		Lig_chan	343..584	CDD:459656	56/267 (21%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	47/212 (22%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	97/389 (25%)