DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grik4

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	676	Identity:	158/676 - (23%)
Similarity:	256/676 - (37%)	Gaps:	153/676 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AKLSHVLI-------------------LHCSLSHLALLA-QSKNI--FTQFQPLHSDIQLNDDFL 58
            |.:|||::                   |..||..|..|| |..||  |:.|...|...|   ||
Zfish   221 ATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDDLADQRVNIVGFSVFNRTHPFFQ---DF- 281

  Fly    59 NHNILKLGVFLDINCDK---SGTVLDMASAKRFFSHRYHWLIYD-------------RSMNFSVL 107
               :|.|......|||.   :||.|..|            |::|             ||.|....
Zfish   282 ---VLSLNRSWQENCDHAPFAGTPLSSA------------LLFDAVHTVVAAVQELNRSQNVGAT 331

  Fly   108 ESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGG-----ELNITADREIFCNK--TNC 165
            :...|.::|:        .|.....|:|      :..:|.|     |.|....|..:..:  .|.
Zfish   332 QLSCKSSKIW--------EHGTSLMNYL------RMVELEGLTGHIEFNSKGQRSNYALRIMQNS 382

  Fly   166 RVE-RYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQL---DTYAR 226
            |.. |.:.:.::...|...:....|.:..|...|.|.:...::..:..:.:.:: :|   |.|..
Zfish   383 RDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQ-ELEGNDRYEG 446

  Fly   227 LGYQARQPLRDMLDCKFKYIFRDRWSDG-----NATG---GMIGDLILDKADLAIAPFIYSFDRA 283
            ......:.|.|:|  ||||..| ...||     .|.|   ||:|:||..|||||:|....:.:|.
Zfish   447 FCVDMLKELADIL--KFKYRIR-LVGDGVYGVPGANGTWTGMVGELISRKADLAVAALTITAERE 508

  Fly   284 L---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTF 343
            .   |.:|...  .|:...:.:.|.|...|       ||.|||.||||...|..|...|:|   |
Zfish   509 KVIDFSKPFMTLGISIMYRVHIGRRPGYFS-------FLDPFSPGVWLFMLLAYLAVSCVL---F 563

  Fly   344 ILERRK--QW---KPSLLTSCLL---------SF----GAGCIQGAWLTPRSMGGR------MAF 384
            ::.|..  :|   .|.|...|.|         ||    |....||:.:.||::..|      .||
Zfish   564 LVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAF 628

  Fly   385 FALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSN-LDVGIEPTVYTRIYVETSEEPDV 448
            ..::::|      ||:.:.:.|..|.::..|.::..|||.. ::.|......|..:.:.|.....
Zfish   629 TLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTY 687

  Fly   449 RDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-P 512
            :.::  ..:.||: |......||.|:..|.: ..:.|:      .|.....:...:.|.|.:| .
Zfish   688 QRMW--NFMYSKQ-PSVFVKSTEEGIARVLN-SNYAYL------LESTMNEYYRQRNCNLTQIGG 742

  Fly   513 LRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAP 576
            |.|.......:...|.|.:...|:.||:.|.......:|.|.:......:.:|.. .:|:|....
Zfish   743 LLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWDGGKCPKEEDHRAKGLGMENIGG 807

  Fly   577 LFIILLGAIILCMGILGLEVIWH-RH 601
            :|::|:..:::.:.:..||.:|. ||
Zfish   808 IFVVLVCGLLVAIFMAVLEFVWMLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	85/338 (25%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	56/268 (21%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	47/211 (22%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	97/389 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740