DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grik2

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	727	Identity:	142/727 - (19%)
Similarity:	255/727 - (35%)	Gaps:	205/727 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NLIHMAKLSHVLILHCSLSHLALL-----AQSK-NIFTQFQPLHSDIQLNDDFLNHNILKLG--- 66
            :|:|..|...|.:::...:.|..|     |.|: ||..:.:.|.:|.:.....|..  :|.|
Zfish   162 DLVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQLPADTKDAKPLLKE--MKRGKEF 224

  Fly    67 -VFLDINCDKSGTVLDMASAKRFFSHRYHWLI---------------------------YDRSMN 103
             |..|...:.:..:|..|.|....:..||::.                           .:.|..
Zfish   225 HVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQV 289

  Fly   104 FSVLE--------------SHFKEAQIFVDADVTY---------------VT--------HDP-- 129
            .|::|              |...:..:..||.:.|               :|        |.|
Zfish   290 SSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQCNRHKPWR 354

  Fly   130 FSKNF--LLYDVYNKGRQLGGELNITADREIFCNKTN-----------CRVERYLSELYT---RS 178
            |...|  |:.:.:..|  |.|.:|.        |:||           ...|..|.::.|   .|
Zfish   355 FGNRFMTLIKEAHWDG--LTGRINF--------NRTNGLRTDFDLDVISLKEEGLEKIGTWDPAS 409

  Fly   179 ALQHRKSFTGLTMRATAVVTALPLNVS------------------------------IKEIFDFM 213
            .|...::..|.|...|..::...|.||                              ::|:...:
Zfish   410 GLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELAAIL 474

  Fly   214 NSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIY 278
            ...|.::|....|.|.|...              ..:|:      ||:.:|:..|||||:||...
Zfish   475 GFGYELRLVEDGRYGAQDES--------------SGQWN------GMVRELMDHKADLAVAPLAI 519

  Fly   279 SFDRALFLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTF 343
            ::.|...:.....|.......::|.|...:.|:.:  ||.|.|..:|:...|..|...|:|:|..
Zfish   520 TYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS--FLNPLSPDIWMYILLAYLGVSCVLFVIA 582

  Fly   344 ILERRKQWKP--------------SLLTSCLLSFGAGCIQGAWLTPRSM-----GGRMAFFALMV 389
            .....:.:.|              :||.|.....||...||:.|.|:::     ||...||.|::
Zfish   583 RFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLII 647

  Fly   390 TSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK 454
            .|     .||:.:.:.|..:.::|.|.:...||..           |:|.....|:......::|
Zfish   648 IS-----SYTANLAAFLTVERMESPIDSADDLAKQ-----------TKIEYGVVEDGSTMTFFKK 696

  Fly   455 KVLGSKRSPDKIW--IPTEAGVLSVRD-QEGFVYITGVATGYEFVRK----HFLAHQICELNEI- 511
            ..:.:.   ||:|  :.:....:.|:. :||...:  :.:.|.|:.:    .|:..:.|.|.:|
Zfish   697 TKISTY---DKMWEFMSSRRHSVMVKSIEEGIERV--LTSDYAFLMESTTIEFVTQRNCNLTQIG 756

  Fly   512 PLRDASHTHTVLAKRSPYAELIKLSELRMLETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAA 575
            .|.|:..........|||.:.|.::.|::.|.| :|...|:.|........::....|:|::...
Zfish   757 GLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEENKEASALGVQNIG 821

  Fly   576 PLFIILLGAIIL 587
            .:||:|...::|
Zfish   822 GIFIVLAAGLVL 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	75/327 (23%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	56/269 (21%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	47/263 (18%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	85/412 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840