DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grin2da

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	489	Identity:	105/489 - (21%)
Similarity:	184/489 - (37%)	Gaps:	139/489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 TGLTMRATAVVTALPLNVS--------------------IKEIFDFMNSKYRIQLDTYARLGYQA 231
            ||..:| .:|...||||.|                    :|.:...:...|.:.|.|..|.|..
Zfish   475 TGSCIR-DSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTNGRHGKN- 537

  Fly   232 RQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSV-F 295
                   :|        .:|:      ||:|:::..:||:||.....:.:|:    .:.:||| |
Zfish   538 -------ID--------GQWN------GMVGEVVSKRADMAIGSLTINEERS----EVVEFSVPF 577

  Fly   296 RE----ICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWV---TFILE------- 346
            .|    :.:.|:..:|    |.:.||:|:|..||     :::...||..|   .||.|
Zfish   578 VETGISVMVSRSNGTV----SPSAFLEPYSPAVW-----VMMFVMCLSVVAVTVFIFEFFSPVGY 633

  Fly   347 -RRKQWKPSLLTSCLLSFGAGCIQGAWL-------------TPRSMGGRM-----AFFALMVTSY 392
             |..|   |..|:....|..|  :..||             .||....::     ||||::..:
Zfish   634 NRSLQ---SGKTAGGSKFTIG--KSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLA- 692

  Fly   393 LMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIE--PTVYTRIYVETSEEPDVR----DL 451
                .||:.:.:.::.:   ..|.|:..|:|.......|  |.:........|.|.::|    ::
Zfish   693 ----SYTANLAAFMIQE---EYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGSTEENIRSNYPNM 750

  Fly   452 YRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAH--QICELNEIPLR 514
            ::..|..::|..:......:.|.|     :.|:|...|.        :::|.  :.|::..|...
Zfish   751 HQYMVRNNQRGVEDAIENLKTGKL-----DAFIYDAAVL--------NYMARKDEGCKVMTIGSG 802

  Fly   515 DASHT---HTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTVAV-----GL 571
            ....|   ...|.|.|.:...:.|:.|:::........||.|:..  .|  ||..:.|     .:
Zfish   803 KVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERLWLSG--IC--HNDKIEVMSSKLDI 863

  Fly   572 EYAAPLFIILLGAIILCMGILGLE--VIWH-RHC 602
            :..|.:|.:||.|:.|.:.:...|  |.|. |||
Zfish   864 DNMAGVFYMLLVAMGLSLLVFAWEHLVYWKLRHC 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	71/344 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	55/283 (19%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	90/441 (20%)
		HisJ	<507..>590	CDD:223904	22/108 (20%)
		Lig_chan	605..877	CDD:278489	60/306 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830