DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Ekar

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	145/732 - (19%)
Similarity:	266/732 - (36%)	Gaps:	203/732 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQLHNL--ILHNLIHMAKLS----------------HVLILHCSLSHLALLAQSKNI------- 40
            ::.||.|  ..|..:||.::|                |.:|:..:.:.:::|.  |||
  Fly   159 IINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILL--KNILQQQMNE 221

  Fly    41 ------FTQFQPLHSDIQLND------DFLN-------------------------HNILKLGVF 68
                  ||.|     |::..|      :|:|                         |:|.| ..:
  Fly   222 YKYHYLFTSF-----DLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFK-KPY 280

  Fly    69 LDINCDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLE-SHFK-------EAQIFVDADVTYV 125
            |:::..|| |:|:...|..|.|      :|..::....|| ||..       |.:...|..::.:
  Fly   281 LNLHIKKS-TILESEPALMFDS------VYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLI 338

  Fly   126 TH----------------DPFSKNFLLYDVYNKGRQL--------GGELNITADREIFCNKTNCR 166
            .:                |.....|.|..:..|...:        .|.|||| :..:|.:..:..
  Fly   339 NYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNIT-EPSMFFDAGSMN 402

  Fly   167 VER-YLSELYTRSALQH-RKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGY 229
            |.. .::.|.|...:.| .|:||| ..|.......:...:|.:..||::       ||......|
  Fly   403 VTLVVITILETPYVMMHYGKNFTG-NERFYGFCVDILETISREVGFDYI-------LDLVPDRKY 459

  Fly   230 QARQPLRDMLDCKFKYIFRDRWSDGNATG---GMIGDLILDKADLAIAPFIYSFDRAL---FLQP 288
            .|:.|                     .||   ||:..|:..|||||:.....::.|..   |.:|
  Fly   460 GAKDP---------------------ETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKP 503

  Fly   289 ITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP 353
            .....:   ..:|:.|.|....|.:  |:.|.:..:|:...:...|....:::...|. ..:||.
  Fly   504 FMNLGI---SILFKVPTSEPTRLFS--FMNPLAIEIWIYVLIAYFLVSLCIYIVGKLS-PIEWKC 562

  Fly   354 ---------------SLLTSCLLSFGAGCIQGAWLTPRSMGGRM-----AFFALMVTSYLMYNYY 398
                           ||..|...:.|....|...:.||:|..|:     .||:|::.:....|..
  Fly   563 INACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLA 627

  Fly   399 TSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK--KVLGS 459
            ..:...::: .||::  ::.:..:::...||.|...|.:....:||         |:|  :.:.:
  Fly   628 AFLTTERMI-NPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIET---------YKKIWRSMDN 682

  Fly   460 KRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVL 523
            |: |.......|.|:..| :|..:.::      .|.....::..:.|.|.:| .|.|........
  Fly   683 KK-PSAFTTTYEDGIKRV-NQGNYAFL------MESTMLDYIVQRDCNLTQIGGLLDTKGYGIAT 739

  Fly   524 AKRSPYAELIKLSELRMLETG-VHFKHERSWMETKLHCYQHNHTV-----AVGLEYAAPLFIILL 582
            .|.||:.:.|.|:.|.:.|.| :...:::.|..|...|.:.|.:.     ::|||....:|::|:
  Fly   740 PKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLI 804

  Fly   583 GAIILCMGILGLEVIWH 599
            ..||:...:...| .|:
  Fly   805 AGIIVAAVVAFFE-FWY 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	67/331 (20%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	55/272 (20%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	43/243 (18%)
		ANF_receptor	39..371	CDD:279440	41/226 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	84/421 (20%)
		Lig_chan	533..807	CDD:278489	57/292 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740