DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Ir93a

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	127/742 - (17%)
Similarity:	241/742 - (32%)	Gaps:	202/742 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHL--ALLAQSKNI-----FTQFQP-LHSDIQLNDDF 57
            :|:.:.|::.:::|.:..:|:..:...|..:  :|..|.|.:     .:||.| .|.:
  Fly   174 ILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEE------- 231

  Fly    58 LNHNILKLGVFLDINCDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESHFKEAQIFVD--- 119
            :....|.:..|.:       .::::|.....|.....|:|:...|    :...|....:.::
  Fly   232 MRQQFLVISAFHE-------DIIEIAETLNMFHVGNQWMIFVLDM----VARDFDAGTVTINLDE 285

  Fly   120 -ADVTYVTH--DPFSKNFLLYDVYNKGRQLGGELN-ITADREIFCNKTN---CRVERYLSELYTR 177
             |::.:..:  ||..::.|...:......|...:: ||.:.|....:.:   ....|:..:....
  Fly   286 GANIAFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQA 350

  Fly   178 SALQHRKSFTGLTMRATA-----VVTAL--------------PLNVSIKEIFDFMNSKY------ 217
            ..|::.|.|.....:.::     |.||:              |...:....|:|:|..|
  Fly   351 EILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLG 415

  Fly   218 -RIQLDTYARLGYQARQPLRDMLD----------------------------------CKFKYIF 247
             ..|...:..:.:..|....|:|.                                  ..|.|..
  Fly   416 FVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYL 480

  Fly   248 RD--RWSD---------GNATGGMIGDL-------ILDKAD------LAIAPFIYSFDRALF--L 286
            .:  .|.:         ||.:..::|.:       :::...      .|:|..:...|:..|  .
  Fly   481 HEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYT 545

  Fly   287 QPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQW 351
            |||   ||.:...:.|.|..||   ....|..||:...|.....::||....|:....|...|:.
  Fly   546 QPI---SVQKYSFITRKPDEVS---RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEM 604

  Fly   352 K---PSLLTSCL-LSFGAGCIQGAWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIK 412
            :   .|.:.||. ..|||...||....|.:..||:......:...::...|...:|:.|.....:
  Fly   605 RIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQ 669

  Fly   413 SNIRTLQQLADSN--LDVGIEPTVYTRIYVETSEEPDVRD-LYRKKVLGSKRSPDKIWIPTEAGV 474
            ..:..|.||.|..  :..|:....:...||:::...|.:. |.|.|:.||.:..|
  Fly   670 PGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYGSAQEED---------- 724

  Fly   475 LSVRDQEGFVYITGVATGYE-----------FVRKHFLAHQICEL---------NEIPLRDASHT 519
                       |..|..|..           .|::||...:.|..         .:|.:
  Fly   725 -----------IEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAM------ 772

  Fly   520 HTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKL----HC-------YQHNHTVAVGLEY 573
              ::..:|.|..|:......|...|.   .|| |.:..|    .|       ...||.|.:. :.
  Fly   773 --IVPAQSAYLHLVNRHIKSMFRMGF---IER-WHQMNLPSAGKCNGKSAQRQVTNHKVNMD-DM 830

  Fly   574 AAPLFIILLGAIILCMGILGLEVIWHR 600
            .....::|||..:..:.:.|  ..|:|
  Fly   831 QGCFLVLLLGFTLALLIVCG--EFWYR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	68/350 (19%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	54/279 (19%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	50/273 (18%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	55/293 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840