DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	101/437 - (23%)
Similarity:	182/437 - (41%)	Gaps:	95/437 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 EIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDGNATG---------GMIGD 263
            |:...:|..|.:.|....:.|:               ||.|      |.||         |:||:
  Fly   475 ELSKRINFTYDLALSPDGQFGH---------------YILR------NNTGAMTLRKEWTGLIGE 518

  Fly   264 LILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTF 328
            |:.::||:.:||...:.:||.::: .:|...::.|.:.....|.|:.|  ..||||||..:|:
  Fly   519 LVNERADMIVAPLTINPERAEYIE-FSKPFKYQGITILEKKPSRSSTL--VSFLQPFSNTLWI-- 578

  Fly   329 ALLLLLAGCLLWVTFILER-------------RKQWKPSLLTSC-------LLSFGAGCIQGAWL 373
             |:::....:..|.::|:|             ..:.|...|:|.       ||:.|.|  :|
  Fly   579 -LVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIG--EG--- 637

  Fly   374 TPRSMGGRM-----AFFALMVTSYLMYNYYTSIVV----SKLLGQPIKSNIRTLQQLADSNLDVG 429
            ||||...|:     |.||:::.:....|....:|:    :||.|........|::.|..:.:. |
  Fly   638 TPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVK-G 701

  Fly   430 IEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYE 494
            ....:|.|..||.|      ::||.....:       :...|..:..|:..:...:|      ::
  Fly   702 SSVDMYFRRQVELS------NMYRTMEANN-------YATAEQAIQDVKKGKLMAFI------WD 747

  Fly   495 FVRKHFLAHQICEL-NEIPLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWM---E 555
            ..|..:.|.:.||| ....|...|.....|.|.||:.:.:.|:.|...|:|...|.::.|:   .
  Fly   748 SSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGH 812

  Fly   556 TKLHCYQHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIWHRH 601
            .:.:|.....|. .:||:..|.:||::...|...:|::.:|||:.:|
  Fly   813 VQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKH 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	79/338 (23%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	60/275 (22%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374
		ANF_receptor	58..371	CDD:279440
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	88/394 (22%)
		HisJ	451..>558	CDD:223904	23/104 (22%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	38/145 (26%)
		Lig_chan	575..838	CDD:278489	62/290 (21%)
		CaM_bdg_C0	854..882	CDD:287524	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840