DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Ir75a

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	246/640 - (38%)
Similarity:	374/640 - (58%)	Gaps:	49/640 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHLALLAQSKNIFTQF-QPLH---------------- 48
            ::||.|.:|.||: .:::..:::.||..|.     :|.....|| :|:|
  Fly     3 LVQLANFVLDNLV-QSRIGFIVLFHCWQSD-----ESLKFAQQFMKPIHPILVYHQFVQMRGVLN 61

  Fly    49 -SDIQLNDDFLNHNILKLGVFLDINCDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESH-- 110
             |.::|:  ::.|....|.:::||.||::..:|:.||.::.::..||||:..   |.|.||.:
  Fly    62 WSHLELS--YMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVG---NQSKLEFYDL 121

  Fly   111 FKEAQIFVDADVTYVTHDPFSKN----FLLYDVYNKGRQLGGELNITADREIFCNKTNCRVERYL 171
            |....|.:||||:||.......|    :.::||||.|:.:||:||:|...|:.|:...||..|:|
  Fly   122 FGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHL 186

  Fly   172 SELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLR 236
            |.|..||...:|:..|.:.:|...|||..||.:|..|:..|::.:....:|:.||.|:.....||
  Fly   187 SSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILR 251

  Fly   237 DMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMF 301
            |:|.||.|:||.|.||..:..||.:|.::...|||...|.:.:..|..:|..|.:...||.:|:|
  Fly   252 DLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIF 316

  Fly   302 RNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILE---RRKQWK----PSLLTSC 359
            |.|.  :|||....||||||..||..|..:|.|.|.|||:||.:|   .:|:|:    ||||::.
  Fly   317 RTPH--NAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTF 379

  Fly   360 LLSFGAGCIQGAWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADS 424
            |:||||.|||.:.|.|||.|||:.:|||.:.|::|||||||:|||.||..|:||.|:|::|||:|
  Fly   380 LISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAES 444

  Fly   425 NLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGV 489
            :|.||:||..:|:.|:..|..|::....::|:....::|: :|:|.|.|||.|||..|:||:...
  Fly   445 SLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPE-LWLPAEQGVLRVRDNPGYVYVFET 508

  Fly   490 ATGYEFVRKHFLAHQICELNEIPLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWM 554
            ::||.:|.::|.|.:||:|||:..|.....:|.|.:.|.|.||.:|..||:|||||:.|....|:
  Fly   509 SSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWV 573

  Fly   555 ETKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVIWH----RHCTLH 605
            ..||||...|..:.||:||.|||.::|:.|.||.:.||.:|:.|.    ||.|.|
  Fly   574 HMKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTFH 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	132/306 (43%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	111/248 (45%)
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	121/266 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446524
Domainoid	1	1.000	59	1.000	Domainoid score	I17734
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26033
OrthoDB	1	1.010	-	-		D191034at33208
OrthoFinder	1	1.000	-	-		FOG0016692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.760