Protein Alignment Ir75b and gria4b

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 542
• Identity: 116/542 - (21%)
• Similarity: 201/542 - (37%)
• Gaps: 136/542 - (25%)

  Fly   125 VTHDPFSK--NFLLYDVY----NKGRQLG-----GELNITADREIFCNKTNCRVERYLSELYTRS 178
            |..|.:.:  |:.: ||:    |..|::|     .:|.:|.|..:..|:|              |
Zfish   361 VQFDHYGRRVNYTM-DVFELKSNGPRRIGYWNDADKLVLTQDHALLPNET--------------S 410

  Fly   179 ALQHRKSFTGLTMRATAVVTAL---PLNVSIK---------------------EIFDFMNSKYRI 219
            .:::|          |.:||.:   |. |.:|                     ||...:..||:|
Zfish   411 GMENR----------TVIVTTIMEGPY-VMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKI 464

  Fly   220 QLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL 284
            .:....:  |.||.|     :.|.       |:      ||:|:|:..||::|:||...:..|..
Zfish   465 SIVPDGK--YGARDP-----ETKI-------WN------GMVGELVYGKAEIAVAPLTITLVREE 509

  Fly   285 ---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLL------- 339
               |.:|.....:   ..|.:.|:....|:.:  ||.|.:..:|:......:....:|
Zfish   510 VIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 569

  Fly   340 ---WVTFILERRKQWKPS--------LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALM 388
               |.|...|......||        :..|...|.||...||..::|||:.||:.     ||.|:
Zfish   570 PYEWHTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 634

  Fly   389 VTSYLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDL 451
            :.|....|....:.|.::: .||:|  ::.....:|...||.|.....:.|..:.         :
Zfish   635 IISSYTANLAAFLTVERMV-SPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKIA---------V 689

  Fly   452 YRKKVLGSKRSPDKIWIPTEA-GVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEIPLR- 514
            |.|.....|.:...::..|.| ||..||..:|.......:|..|:..:    .:.|:..::...
Zfish   690 YEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQ----RKPCDTMKVGGNL 750

  Fly   515 DASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHC------YQHNHTVAVGLEY 573
            |:........|.|.....:.|:.|::.|.|:..|.:..|...|..|      .:...:.|:.|..
Zfish   751 DSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQALSLSN 815

  Fly   574 AAPLFIILLGAIILCMGILGLE 595
            .|.:|.||:|.:.|.|.:..:|
Zfish   816 VAGVFYILVGGLGLAMLVALIE 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	11/47 (23%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	18/68 (26%)
		Lig_chan	343..584	CDD:459656	58/263 (22%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	9/39 (23%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	90/428 (21%)
		Lig_chan	546..826	CDD:459656	62/293 (21%)