DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and GluRIIE

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	103/447 - (23%)
Similarity:	168/447 - (37%)	Gaps:	102/447 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 NSKYRIQLDTYARL---------GYQARQPLRDMLDCKFKYIFRDRWSDGNATG----------G 259
            |..|...::||.:|         |....:.|.|.|...|.::     :.||..|          |
  Fly   430 NKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFV-----NGGNDYGSYNKSTNESTG 489

  Fly   260 MIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGV 324
            |:.:::..:|||||.....:.:|...|.....|.......::..|:..:..|..  |:.|||..|
  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFT--FMDPFSEEV 552

  Fly   325 W--LTFALLLLLAGCLLWVTFILER--RKQW--------KP-------SLLTSCLLSFGAGCIQG 370
            |  |.|:.|    |..| ..|||.|  ..:|        :|       :|..|...:.||...||
  Fly   553 WWFLGFSFL----GVSL-SFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQG 612

  Fly   371 AWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDV-- 428
            :.:.|:::..|..     ||.|:|.|     .||:.:.:.|..:..:|.|.::..|||:...|
  Fly   613 SEIGPKALSTRTVASFWWFFTLIVVS-----SYTANLAAFLTIEKPQSLINSVDDLADNKDGVVY 672

  Fly   429 GIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGY 493
            |.:.|..||.:..||.|    :.|:|.......:|..:......||..|:....:.::. .:|..
  Fly   673 GAKKTGSTRNFFMTSAE----ERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLM-ESTSI 732

  Fly   494 EFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETK 557
            |:..|     :.|.|.:| ...|.......:.|..|:......:.|.:.|.||..|.:..|.
  Fly   733 EYNTK-----RECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW--- 789

  Fly   558 LHCYQHNHTVAVGL-------EYAAPL---------FIILLGAIILCMGILGLEVIW 598
                   :.|..|:       ..|.||         |::|:|:   |..:|...:.|
  Fly   790 -------NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGS---CCALLYGIISW 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	81/336 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	64/282 (23%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	92/396 (23%)
		Lig_chan	551..824	CDD:278489	70/302 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740