Protein Alignment Ir75b and Grik3

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001106187.1
• Gene: Grik3 / 298521
• RGDID: 71027
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 127/573 - (22%)
• Similarity: 212/573 - (36%)
• Gaps: 143/573 - (24%)

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQ--------IF---------VDADVTYVTHDPFSKNFLLY 137
            ||:. |....|.|||      .||||        :|         .|.|:..:..|...|    .
  Rat   351 HRHKAWRFGGRFMNF------IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEK----V 405

  Fly   138 DVYNKGRQLGGELNITADREIF----CNKTNCRVERYL--SELYTRSALQHRKS---------FT 187
            .|::.    ...||||   |:.    .|.|:....|.|  :.|.....:..|||         |.
  Rat   406 GVWSP----ADGLNIT---EVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFE 463

  Fly   188 GLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWS 252
            |..:..            :||:...:...|.|:|....:.|.|                     .
  Rat   464 GYCIDL------------LKELAHILGFSYEIRLVEDGKYGAQ---------------------D 495

  Fly   253 DGNATGGMIGDLILDKADLAIAPFIYSF--DRAL-FLQPITKFSVFREICMFRNPRSVSAGLSAT 314
            |.....||:.:||..|||||:||...:.  ::|: |.:|.....|   ..::|.|...:.  |..
  Rat   496 DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV---SILYRKPNGTNP--SVF 555

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRK--QW------KP---------SLLTSCLLS 362
            .||.|.|..:|:...|..|...|:|   |::.|..  :|      .|         :||.|....
  Rat   556 SFLNPLSPDIWMYVLLAYLGVSCVL---FVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFG 617

  Fly   363 FGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLA 422
            .|:...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:...||
  Rat   618 MGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADDLA 677

  Fly   423 DSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSP-DKIW--IPTEAGVLSVRDQEGF- 483
            ..           |:|.....::......::|    ||.|. :|:|  :.::...|...::||.
  Rat   678 KQ-----------TKIEYGAVKDGATMTFFKK----SKISTFEKMWAFMSSKPSALVKNNEEGIQ 727

  Fly   484 -VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETG-V 545
             ......|...|.....::..:.|.|.:| .|.|:..........|||.:.|.::.|::.|.. :
  Rat   728 RTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   546 HFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            |...|:.|..:.....::....|:|::....:||:|...::|.:.:...|.|:
  Rat   793 HIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIY 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	12/49 (24%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	22/68 (32%)
		Lig_chan	343..584	CDD:459656	57/269 (21%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate	37..417	CDD:380605	19/79 (24%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	94/428 (22%)