DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grik3

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	127/573 - (22%)
Similarity:	212/573 - (36%)	Gaps:	143/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQ--------IF---------VDADVTYVTHDPFSKNFLLY 137
            ||:. |....|.|||      .||||        :|         .|.|:..:..|...|    .
  Rat   351 HRHKAWRFGGRFMNF------IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEK----V 405

  Fly   138 DVYNKGRQLGGELNITADREIF----CNKTNCRVERYL--SELYTRSALQHRKS---------FT 187
            .|::.    ...||||   |:.    .|.|:....|.|  :.|.....:..|||         |.
  Rat   406 GVWSP----ADGLNIT---EVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFE 463

  Fly   188 GLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWS 252
            |..:..            :||:...:...|.|:|....:.|.|                     .
  Rat   464 GYCIDL------------LKELAHILGFSYEIRLVEDGKYGAQ---------------------D 495

  Fly   253 DGNATGGMIGDLILDKADLAIAPFIYSF--DRAL-FLQPITKFSVFREICMFRNPRSVSAGLSAT 314
            |.....||:.:||..|||||:||...:.  ::|: |.:|.....|   ..::|.|...:.  |..
  Rat   496 DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV---SILYRKPNGTNP--SVF 555

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRK--QW------KP---------SLLTSCLLS 362
            .||.|.|..:|:...|..|...|:|   |::.|..  :|      .|         :||.|....
  Rat   556 SFLNPLSPDIWMYVLLAYLGVSCVL---FVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFG 617

  Fly   363 FGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLA 422
            .|:...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:...||
  Rat   618 MGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADDLA 677

  Fly   423 DSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSP-DKIW--IPTEAGVLSVRDQEGF- 483
            ..           |:|.....::......::|    ||.|. :|:|  :.::...|...::||.
  Rat   678 KQ-----------TKIEYGAVKDGATMTFFKK----SKISTFEKMWAFMSSKPSALVKNNEEGIQ 727

  Fly   484 -VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETG-V 545
             ......|...|.....::..:.|.|.:| .|.|:..........|||.:.|.::.|::.|.. :
  Rat   728 RTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   546 HFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            |...|:.|..:.....::....|:|::....:||:|...::|.:.:...|.|:
  Rat   793 HIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIY 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	79/331 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	57/270 (21%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	19/79 (24%)
		ANF_receptor	55..398	CDD:279440	14/52 (27%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	94/428 (22%)
		Lig_chan	564..832	CDD:278489	62/290 (21%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740