Protein Alignment Ir75b and Gria3

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 561
• Identity: 119/561 - (21%)
• Similarity: 204/561 - (36%)
• Gaps: 172/561 - (30%)

  Fly    94 HWLIYDRSMNFSVLESHFKEAQIFVDAD--------VTYVTHDPFSKNFLLYDVYNKG-RQLGGE 149
            :|..|:|.:.||       :.||..|:.        ||.:...|       |.:|.|. .||.|
  Rat   392 YWNEYERFVPFS-------DQQISNDSSSSENRTIVVTTILESP-------YVMYKKNHEQLEG- 441

  Fly   150 LNITADREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMN 214
                          |.|.|.|..:|                               ..||...:.
  Rat   442 --------------NERYEGYCVDL-------------------------------AYEIAKHVR 461

  Fly   215 SKYRIQLDTYARLG---YQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPF 276
            .||::.:     :|   |.||.|     :.|.       |:      ||:|:|:..:||:|:||.
  Rat   462 IKYKLSI-----VGDGKYGARDP-----ETKI-------WN------GMVGELVYGRADIAVAPL 503

  Fly   277 IYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCL 338
            ..:..|..   |.:|.....:   ..|.:.|:....|:.:  ||.|.:..:|:          |:
  Rat   504 TITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPLAYEIWM----------CI 553

  Fly   339 LW-------VTFILERRK--QW-------KP-------------SLLTSCLLSFGAGCIQGAWLT 374
            ::       |.|::.|..  :|       :|             .:..|...|.||...||..::
  Rat   554 VFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDIS 618

  Fly   375 PRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEP 432
            |||:.||:.     ||.|::.|....|....:.|.::: .||:|  ::....::|...||.|...
  Rat   619 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDSGSTK 682

  Fly   433 TVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEA-GVLSVRDQEG-FVYITGVATGYEF 495
            ..:.|..:.         :|.|.....|.:...::..|.| ||..||..:| |.::. .:|..|:
  Rat   683 EFFRRSKIA---------VYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL-ESTMNEY 737

  Fly   496 VRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLH 559
            :.:    .:.|:..::... |:........|.|.....:.|:.|::.|.|:..|.:..|...|..
  Rat   738 IEQ----RKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGE 798

  Fly   560 C-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLE 595
            |     ...:.|.|:.|...|.:|.||:|.:.|.|.:..:|
  Rat   799 CGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	11/47 (23%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	18/68 (26%)
		Lig_chan	343..584	CDD:459656	61/277 (22%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	3/10 (30%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	99/488 (20%)