Protein Alignment Ir75b and Grik1

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 569
• Identity: 119/569 - (20%)
• Similarity: 209/569 - (36%)
• Gaps: 141/569 - (24%)

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQ-IFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGGELNIT 153
            ||:. |.:..|.||.      .|||: ..:...:|:...|...|:|              :|:|.
  Rat   349 HRHKPWRLGPRFMNL------IKEARWDGLTGRITFNKTDGLRKDF--------------DLDII 393

  Fly   154 ADREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTM----------------RATAVVTAL-- 200
            :.:|....|.:..|.::|.:::.:..:.:..|  ||.|                ..|.:||.:
  Rat   394 SLKEEGTEKASGEVSKHLYKVWKKIGIWNSNS--GLNMTDGNRDRSNNITDSLANRTLIVTTILE 456

  Fly   201 -----------PLNVS----------IKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFK 244
                       ||..:          :||:.:.:...|.::|....:.|.|
  Rat   457 EPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQ-------------- 507

  Fly   245 YIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSA 309
                   :|.....||:.:||..:||||:||...::.|...:.....|.......::|.|...:.
  Rat   508 -------NDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNP 565

  Fly   310 GLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP--------------SLLTSCL 360
            |:.:  ||.|.|..:|:...|..|...|:|:|.......:.:.|              :||.|..
  Rat   566 GVFS--FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 628

  Fly   361 LSFGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQ 420
            ...||...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:...
  Rat   629 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADD 688

  Fly   421 LADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQ----- 480
            ||..           |:|......:......::|..:.:.   :|:|     ..:|.|.|
  Rat   689 LAKQ-----------TKIEYGAVRDGSTMTFFKKSKISTY---EKMW-----AFMSSRQQSALVK 734

  Fly   481 ---EGF--VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELR 539
               ||.  |..|..|...|.....::..:.|.|.:| .|.|:..........|||.:.|.::.|:
  Rat   735 NSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQ 799

  Fly   540 MLETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIIL 587
            :.|.| :|...|:.|..............|:|:|....:||:|...::|
  Rat   800 LQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVL 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	11/47 (23%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	19/65 (29%)
		Lig_chan	343..584	CDD:459656	58/271 (21%)
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	23/103 (22%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	88/415 (21%)