DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and GRIK5

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	675	Identity:	154/675 - (22%)
Similarity:	258/675 - (38%)	Gaps:	148/675 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KLSHVLI-LHCSLSHLALLAQS---------KNIFT--QFQPLHSDIQLNDDFLNHNILKLGVF- 68
            |:|.::| .:.|:|||.|...|         |.|.|  .|..||.|..:.|   :.|||...:|
Human   210 KVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVED---SSNILGFSMFN 271

  Fly    69 ------------LDI----NCDKSGTVLDMASAKRFFSHRYHWLI-----YDRSMNFSVLESHFK 112
                        |::    ||:.| |.|..|.:........|.::     .:||....|......
Human   272 TSHPFYPEFVRSLNMSWRENCEAS-TYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACT 335

  Fly   113 EAQIFVDADVTYVTHDPFSKNFLLYDVYN--KGRQLGGELNITADREIFCNKTNCRVERYLSELY 175
            .|.|:        .|.....|:|....|:  .||.   |.|....|      ||     |...:.
Human   336 SANIW--------PHGTSLMNYLRMVEYDGLTGRV---EFNSKGQR------TN-----YTLRIL 378

  Fly   176 TRSALQHRKSFTGLTMRATAV-VTALPLNVS------IKEIFDFMNSKYRIQLDTYARLGYQAR- 232
            .:|...||:.....:.|..|: .|.|.:|:|      ...:...:.:.|.::...:..|....|
Human   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERF 443

  Fly   233 -----QPLRDMLD-CKFKYIFR-------------DRWSDGNATGGMIGDLI-LDKADLAIAPFI 277
                 ..||::.: .:|:|..|             ..|:      ||:|:|| ..|||||:|.|.
Human   444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWT------GMVGELINRQKADLAVAAFT 502

  Fly   278 YSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGC 337
            .:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||..|||...|..|...|
Human   503 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS-------FLDPFSPAVWLFMLLAYLAVSC 560

  Fly   338 LLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRSMGGR------ 381
            :|::...|...:.:.|               :|..|.....|....||:.:.||::..|
Human   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625

  Fly   382 MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTVYTRIYVETSEE 445
            .||..::::|      ||:.:.:.|..|.::..:.:...||| :|::.|......|..:.:.|..
Human   626 WAFTLIIISS------YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY 684

  Fly   446 PDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNE 510
            ...:.::  ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|:     ..|.|.:
Human   685 QTYQRMW--NYMQSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHRR-----LNCNLTQ 739

  Fly   511 I-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEY 573
            | .|.|.......:...||:.:.|.|:.|::.|.......:|.|.|......:.:|.. .:|:|.
Human   740 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMEN 804

  Fly   574 AAPLFIILLGAIILCMGILGLEVIW 598
            ...:||:|:..:|:.:.:..:|.||
Human   805 IGGIFIVLICGLIIAVFVAVMEFIW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	78/328 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	54/265 (20%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	50/214 (23%)
		ANF_receptor	42..379	CDD:279440	46/194 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	88/399 (22%)
		Lig_chan	546..816	CDD:278489	61/285 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840