Protein Alignment Ir75b and GRIK4

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 161/713 - (22%)
• Similarity: 267/713 - (37%)
• Gaps: 163/713 - (22%)

  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHLALLAQSKNIFTQFQPLHSDIQLNDDFLNHNILKL 65
            :|.|..|:...||....|| |.:|..:.....||.:.::..|....:|::..     ::|.||
Human   172 LLNLEKLLRQFLISKDTLS-VRMLDDTRDPTPLLKEIRDDKTATIIIHANAS-----MSHTIL-- 228

  Fly    66 GVFLDINCDKSGTVLDMASA--------KRFFSHRYHWLIYDR--SMNFSVL-ESH--FKE-AQI 116
                     .....|.|.||        ..|...|...|:.||  .:.||:. :||  |:| ||.
Human   229 ---------LKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQS 284

  Fly   117 FVDADVTYVTHDPFS----KNFLLYD-VY---------NKGRQLGGELNITADREIFCNKTNCRV 167
            ...:......|.||:    .:.||:| ||         |:.:::|.:.......:|:.:.|:...
Human   285 LNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMN 349

  Fly   168 ERYLSEL-----------------YTRSALQH-RKSF---------TGLTM-------------- 191
            ...:.||                 |....||. |..|         .||:|
Human   350 YLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLF 414

  Fly   192 RATAVVTALPLN--VSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDG 254
            ..|.|||.:..|  :.:|.....|...     |.|........:.|.::|  :|.|..| ...||
Human   415 NTTLVVTTILENPYLMLKGNHQEMEGN-----DRYEGFCVDMLKELAEIL--RFNYKIR-LVGDG 471

  Fly   255 -----NATG---GMIGDLILDKADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRS 306
                 .|.|   ||:|:||..|||||:|....:.:|..   |.:|...  .|:...:.|.|.|..
Human   472 VYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGY 536

  Fly   307 VSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP---------------SLL 356
            .|       ||.|||.||||...|..|...|:|::...|...:.:.|               ||.
Human   537 FS-------FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   357 TSCLLSFGAGCIQGAWLTPRSMGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNI 415
            .|.....|....||:.:.||::..|      .||..::::|      ||:.:.:.|..|.:...|
Human   595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMDVPI 653

  Fly   416 RTLQQLADSN-LDVGIEPTVY---TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLS 476
            .::..|||.. ::.|   |::   :..:.:.|.....:.::  ..:.||: |......||.|:..
Human   654 ESVDDLADQTAIEYG---TIHGGSSMTFFQNSRYQTYQRMW--NYMYSKQ-PSVFVKSTEEGIAR 712

  Fly   477 VRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRM 540
            |.: ..:.::      .|.....:...:.|.|.:| .|.|.......:...|.:.:...|:.|::
Human   713 VLN-SNYAFL------LESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQL 770

  Fly   541 LETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIWH-RH 601
            .|.......:|.|.|......:.:|.. .:|:|....:|::|:..:|:.:.:..||.:|. ||
Human   771 QENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	20/55 (36%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	25/70 (36%)
		Lig_chan	343..584	CDD:459656	50/267 (19%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	55/246 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	94/403 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956