DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75b and GRIK4

DIOPT Version :9

Sequence 1:NP_001137966.2 Gene:Ir75b / 8673994 FlyBaseID:FBgn0261402 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:713 Identity:161/713 - (22%)
Similarity:267/713 - (37%) Gaps:163/713 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHLALLAQSKNIFTQFQPLHSDIQLNDDFLNHNILKL 65
            :|.|..|:...||....|| |.:|..:.....||.:.::..|....:|::..     ::|.||  
Human   172 LLNLEKLLRQFLISKDTLS-VRMLDDTRDPTPLLKEIRDDKTATIIIHANAS-----MSHTIL-- 228

  Fly    66 GVFLDINCDKSGTVLDMASA--------KRFFSHRYHWLIYDR--SMNFSVL-ESH--FKE-AQI 116
                     .....|.|.||        ..|...|...|:.||  .:.||:. :||  |:| ||.
Human   229 ---------LKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQS 284

  Fly   117 FVDADVTYVTHDPFS----KNFLLYD-VY---------NKGRQLGGELNITADREIFCNKTNCRV 167
            ...:......|.||:    .:.||:| ||         |:.:::|.:.......:|:.:.|:...
Human   285 LNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMN 349

  Fly   168 ERYLSEL-----------------YTRSALQH-RKSF---------TGLTM-------------- 191
            ...:.||                 |....||. |..|         .||:|              
Human   350 YLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLF 414

  Fly   192 RATAVVTALPLN--VSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDG 254
            ..|.|||.:..|  :.:|.....|...     |.|........:.|.::|  :|.|..| ...||
Human   415 NTTLVVTTILENPYLMLKGNHQEMEGN-----DRYEGFCVDMLKELAEIL--RFNYKIR-LVGDG 471

  Fly   255 -----NATG---GMIGDLILDKADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRS 306
                 .|.|   ||:|:||..|||||:|....:.:|..   |.:|...  .|:...:.|.|.|..
Human   472 VYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGY 536

  Fly   307 VSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP---------------SLL 356
            .|       ||.|||.||||...|..|...|:|::...|...:.:.|               ||.
Human   537 FS-------FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   357 TSCLLSFGAGCIQGAWLTPRSMGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNI 415
            .|.....|....||:.:.||::..|      .||..::::|      ||:.:.:.|..|.:...|
Human   595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMDVPI 653

  Fly   416 RTLQQLADSN-LDVGIEPTVY---TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLS 476
            .::..|||.. ::.|   |::   :..:.:.|.....:.::  ..:.||: |......||.|:..
Human   654 ESVDDLADQTAIEYG---TIHGGSSMTFFQNSRYQTYQRMW--NYMYSKQ-PSVFVKSTEEGIAR 712

  Fly   477 VRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRM 540
            |.: ..:.::      .|.....:...:.|.|.:| .|.|.......:...|.:.:...|:.|::
Human   713 VLN-SNYAFL------LESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQL 770

  Fly   541 LETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIWH-RH 601
            .|.......:|.|.|......:.:|.. .:|:|....:|::|:..:|:.:.:..||.:|. ||
Human   771 QENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75bNP_001137966.2 Periplasmic_Binding_Protein_Type_2 253..553 CDD:304360 79/338 (23%)
Lig_chan 343..585 CDD:278489 50/268 (19%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 54/244 (22%)
ANF_receptor 43..382 CDD:279440 50/226 (22%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 94/403 (23%)
Lig_chan 547..816 CDD:278489 57/287 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155761
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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