Protein Alignment Ir75b and GRIK3

DIOPT Version :9

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 123/577 - (21%)
• Similarity: 204/577 - (35%)
• Gaps: 173/577 - (29%)

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQ--------IF---------VDADVTYVTHDPFSK----- 132
            ||:. |....|.|||      .||||        :|         .|.|:..:..|...|
Human   351 HRHKAWRFGGRFMNF------IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWS 409

  Fly   133 --NFLLYDVYNKGRQLGGELNIT-----------------------ADREIFCNKTNCRVERYLS 172
              :.|......|||   |. |:|                       :||.::.|.   |.|.|..
Human   410 PADGLNITEVAKGR---GP-NVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGND---RFEGYCI 467

  Fly   173 ELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRD 237
            :|                               :||:...:...|.|:|....:.|.|
Human   468 DL-------------------------------LKELAHILGFSYEIRLVEDGKYGAQ------- 494

  Fly   238 MLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSF--DRAL-FLQPITKFSVFREIC 299
                          .|.....||:.:||..|||||:||...:.  ::|: |.:|.....|   ..
Human   495 --------------DDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV---SI 542

  Fly   300 MFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRK--QW------KP--- 353
            ::|.|...:.  |...||.|.|..:|:...|..|...|:|   |::.|..  :|      .|
Human   543 LYRKPNGTNP--SVFSFLNPLSPDIWMYVLLAYLGVSCVL---FVIARFSPYEWYDAHPCNPGSE 602

  Fly   354 ------SLLTSCLLSFGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLL 407
                  :||.|.....|:...||:.|.|:::     ||...||.|::.|     .||:.:.:.|.
Human   603 VVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTANLAAFLT 662

  Fly   408 GQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSP-DKIW--IP 469
            .:.::|.|.:...||..           |:|.....::......::|    ||.|. :|:|  :.
Human   663 VERMESPIDSADDLAKQ-----------TKIEYGAVKDGATMTFFKK----SKISTFEKMWAFMS 712

  Fly   470 TEAGVLSVRDQEGF--VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAE 531
            ::...|...::||.  ......|...|.....::..:.|.|.:| .|.|:..........|||.:
Human   713 SKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRD 777

  Fly   532 LIKLSELRMLETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIIL 587
            .|.::.|::.|.. :|...|:.|..:.....::....|:|::....:||:|...::|
Human   778 KITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	79/331 (24%)
		Lig_chan	343..585	CDD:278489	57/270 (21%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	17/71 (24%)
		ANF_receptor	55..398	CDD:279440	14/52 (27%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	93/450 (21%)
		Lig_chan	564..832	CDD:278489	62/290 (21%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740