back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and GRIK2

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	569	Identity:	124/569 - (21%)
Similarity:	210/569 - (36%)	Gaps:	134/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDP--FSKNF--LLYDVYNKGRQLGGELNITADR 156
            |:||.....||....|.:..:   :.:....|.|  |...|  |:.:.:.:|  |.|.:..
Human   322 LMYDAVHVVSVAVQQFPQMTV---SSLQCNRHKPWRFGTRFMSLIKEAHWEG--LTGRITF---- 377

  Fly   157 EIFCNKTN-----------CRVERYLSELYT---RSALQHRKSFTG--------LTMRATAVVTA 199
                ||||           ...|..|.::.|   .|.|...:|..|        |:.|:..|.|.
Human   378 ----NKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTI 438

  Fly   200 L------------PLNVS----------IKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCK 242
            |            ||..:          ::|:...:...|.|:|....:.|.|
Human   439 LEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQ------------ 491

  Fly   243 FKYIFRDRWSDGNAT-GGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRS 306
                     .|.|.. .||:.:||..|||||:||...::.|...:.....|.......::|.|..
Human   492 ---------DDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNG 547

  Fly   307 VSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP--------------SLLT 357
            .:.|:.:  ||.|.|..:|:...|..|...|:|:|.......:.:.|              :||.
Human   548 TNPGVFS--FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLN 610

  Fly   358 SCLLSFGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRT 417
            |.....||...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:
Human   611 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDS 670

  Fly   418 LQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWI---PTEAGVLSVRD 479
            ...||..           |:|.....|:......::|..:.:.   ||:|.   .....||...:
Human   671 ADDLAKQ-----------TKIEYGAVEDGATMTFFKKSKISTY---DKMWAFMSSRRQSVLVKSN 721

  Fly   480 QEGFVYITGVATGYEFVRK----HFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELR 539
            :||...:  :.:.|.|:.:    .|:..:.|.|.:| .|.|:..........|||.:.|.::.|:
Human   722 EEGIQRV--LTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQ 784

  Fly   540 MLETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIIL 587
            :.|.| :|...|:.|........:.....|:|::....:||:|...::|
Human   785 LQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVL 833

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.