Protein Alignment Ir75b and GRIK1

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 122/579 - (21%)
• Similarity: 215/579 - (37%)
• Gaps: 139/579 - (24%)

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGGELNITA 154
            ||:. |.:..|.||.      .|||:  .|....::|   |:|        ..|.:...:|:|.:
Human   349 HRHKPWRLGPRFMNL------IKEAR--WDGLTGHIT---FNK--------TNGLRKDFDLDIIS 394

  Fly   155 DREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTM----------------RATAVVTAL--- 200
            .:|....|....|.::|.:::.:..:.:..|  ||.|                ..|.:||.:
Human   395 LKEEGTEKAAGEVSKHLYKVWKKIGIWNSNS--GLNMTDSNKDKSSNITDSLANRTLIVTTILEE 457

  Fly   201 ----------PLNVS----------IKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKY 245
                      ||..:          :||:.:.:...|.::|....:.|.|
Human   458 PYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQ--------------- 507

  Fly   246 IFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAG 310
                  :|.....||:.:||..:||||:||...::.|...:.....|.......::|.|...:.|
Human   508 ------NDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 566

  Fly   311 LSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP--------------SLLTSCLL 361
            :.:  ||.|.|..:|:...|..|...|:|:|.......:.:.|              :||.|...
Human   567 VFS--FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWF 629

  Fly   362 SFGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQL 421
            ..||...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:...|
Human   630 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADDL 689

  Fly   422 ADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQ------ 480
            |..           |:|......:......::|..:.:.   :|:|     ..:|.|.|
Human   690 AKQ-----------TKIEYGAVRDGSTMTFFKKSKISTY---EKMW-----AFMSSRQQTALVRN 735

  Fly   481 --EGF--VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRM 540
              ||.  |..|..|...|.....::..:.|.|.:| .|.|:..........|||.:.|.::.|::
Human   736 SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800

  Fly   541 LETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            .|.| :|...|:.|.........:....|:|:|....:||:|...::|.:.:...|.|:
Human   801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	11/47 (23%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	19/65 (29%)
		Lig_chan	343..584	CDD:459656	58/271 (21%)
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	24/102 (24%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	88/415 (21%)