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Protein Alignment Ir75b and GRIK1

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	579	Identity:	122/579 - (21%)
Similarity:	215/579 - (37%)	Gaps:	139/579 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 HRYH-WLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYNKGRQLGGELNITA 154
            ||:. |.:..|.||.      .|||:  .|....::|   |:|        ..|.:...:|:|.:
Human   349 HRHKPWRLGPRFMNL------IKEAR--WDGLTGHIT---FNK--------TNGLRKDFDLDIIS 394

  Fly   155 DREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTM----------------RATAVVTAL--- 200
            .:|....|....|.::|.:::.:..:.:..|  ||.|                ..|.:||.:
Human   395 LKEEGTEKAAGEVSKHLYKVWKKIGIWNSNS--GLNMTDSNKDKSSNITDSLANRTLIVTTILEE 457

  Fly   201 ----------PLNVS----------IKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKY 245
                      ||..:          :||:.:.:...|.::|....:.|.|
Human   458 PYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQ--------------- 507

  Fly   246 IFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAG 310
                  :|.....||:.:||..:||||:||...::.|...:.....|.......::|.|...:.|
Human   508 ------NDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 566

  Fly   311 LSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP--------------SLLTSCLL 361
            :.:  ||.|.|..:|:...|..|...|:|:|.......:.:.|              :||.|...
Human   567 VFS--FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWF 629

  Fly   362 SFGAGCIQGAWLTPRSM-----GGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQL 421
            ..||...||:.|.|:::     ||...||.|::.|     .||:.:.:.|..:.::|.|.:...|
Human   630 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADDL 689

  Fly   422 ADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQ------ 480
            |..           |:|......:......::|..:.:.   :|:|     ..:|.|.|
Human   690 AKQ-----------TKIEYGAVRDGSTMTFFKKSKISTY---EKMW-----AFMSSRQQTALVRN 735

  Fly   481 --EGF--VYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRM 540
              ||.  |..|..|...|.....::..:.|.|.:| .|.|:..........|||.:.|.::.|::
Human   736 SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 800

  Fly   541 LETG-VHFKHERSWMETKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            .|.| :|...|:.|.........:....|:|:|....:||:|...::|.:.:...|.|:
Human   801 QEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.